Why We Need Pyrroloquinoline Quinone (PQQ)
As people age, their brain becomes compelled to battle multiple sources of damage. While some sources of damage register zero to minimal effect on the human brain, certain damages become a contributory factor to neurodegenerative disorders and progressive injuries that affect the blood vessels. In recent years, people have become more concerned about brain health and thus, the research, as well as awareness around brain function and health, has significantly intensified. Researchers are continually conducting studies to study and analyze the effect of various chemicals and compounds on the health of the human brain. One such compound which has evoked the interested of researchers and scientists around the world is Pyrroloquinoline Quinone (PQQ). In this article, we discuss everything there is to know about Pyrroloquinoline Quinone, including its function, benefits, dosage limitations and side effects. So, read on.
What is Pyrroloquinoline Quinone (PQQ)?
Pyrroloquinoline Quinone or PQQ is a compound that exists in plants as well as many bacteria and single-cell eukaryotes, such as yeast. PQQ also exists naturally in human breast milk as well as fermented soybeans, kiwi, papaya, spinach, parsley, oolong, green pepper and green tea. Research done on animals has linked insufficient PQQ or PQQ shortage with a compromised immune response, growth impairment, abnormal reproductive performance and reduced metabolic flexibility.
For many years, researchers thought Pyrroloquinoline Quinone (PQQ) is a type of vitamin. However, research done over the last few years has revealed that Pyrroloquinoline Quinone is a nutrient with vitamin-like qualities that has the capacity to act as a co-factor or enzyme booster in the reduction-oxidation process which involves the transfer of electrons between two species. In simple words, PQQ binds itself with quinoproteins present in the body and works in collaboration with them to get rid of the free radicals. A research study found quinoproteins to be 100 times more effective than Vitamin – C as an anti-oxidant. Recent studies have also revealed that PQQ affects energy transfer and cellular metabolism by increasing the total number of mitochondria within the body. It is these important facts that have caused a sudden rise in the popularity of Pyrroloquinoline quinone in recent years.
Pyrroloquinoline Quinone (PQQ) Benefits
The interest in Pyrroloquinoline Quinone has increased considerably during the last few years as this compound has been linked with several benefits. Here, we look at its most important Pyrroloquinoline Quinone (PQQ) benefits.
●PQQ Has Been Linked with Improved Overall Energy
Mitochondria are tiny organelles that exist within the cells and are often referred to as cell powerhouses as they release energy from food, thereby providing the energy the cells need to do their function. Pyrroloquinoline Quinone allows mitochondria to work better, thereby leading to increased energy production within the cells. This increased energy within the cells eventually finds its way to the entire body, in turn leading to more stamina and overall energy. If you often experience lethargy or low energy, PQQ supplements will help you boost your energy levels.
●It Improves Nerve Growth Factors
Pyrroloquinoline Quinone interacts with cellular pathways and in the process, invariably positively affects nerve growth factors. This, in turn, leads to enhanced development of neuronal cells and nerves in the cranial tissue. Thus, PQQ is often linked with improved brain function. Since NGF dysregulation is often linked with Alzheimer’s disease, PQQ supplements are often prescribed to aid the treatment of age-related conditions.
●PQQ Intake Has Been Linked with Improved Sleep
A study analyzed the effect of PQQ intake on people’s sleep. The study analyzed participants over a period of eight weeks and found that those who regularly consumed for eight weeks were able to sleep better. The study also revealed that PQQ intake reduces cortisol, the stress hormone that interrupts with normal sleep. Though more research is needed in this particular area, preliminary research clearly links PQQ intake with improved sleep.
●PQQ Promotes Overall Well-Being by Reducing Oxidative Stress
PQQ is known for its high anti-oxidant properties — it decreases the level of C-reactive protein and IL-6 within the body, both of which are responsible for inflammation. Its oxidative properties also make PQQ an effective fighter against oxidative stress, which is a common cause of several chronic diseases, such as carcinomas and neurodegenerative diseases. PQQ reduces stress by reducing the oxidative damage caused by free radicals and enhancing metabolism.
●PQQ in Combination with CoQ10 Improves Memory Function
PQQ intake has been linked with reduced stress, which in turn, leads to enhanced cognitive function and improvements to memory. Research studies have been conducted to study how PQQ affects memory. A research study found that PQQ works in collaboration with CoQ10, a coenzyme that works as an antioxidant that boosts metabolism and protects cells from damage. PQQ in combination with CoQ10 has shown to improve memory function.
●Other Benefits of PQQ
Over and above the aforementioned benefits, PQQ also offers some other benefits the research on which is currently underway. For instance, preliminary research has proven that PQQ intake also leads to improved fertility.
Pyrroloquinoline Quinone (PQQ) Dosage
So far no upper or lower limit has been established on Pyrroloquinoline Quinone (PQQ) dosage. However, results inferred from animal studies reveal that this compound becomes bioactive when taken in doses as low as 2 mg. However, most dietary supplements these days are available in the range of 20 mg to 40 mg, which is considered to be a safe range. PQQ is mostly available in the form of capsules, which people are advised to take on an empty stomach. However, users are advised to not go beyond 80 mg dosage per day.
Is Pyrroloquinoline Quinone (PQQ) Safe?
Research done so far has established that PQQ is well-tolerated by the body when taken within the prescribed limits. However, exceeding the prescribed dosage can lead to side-effects, such as headaches, fatigue, and drowsiness. Thus, users are advised to stick to the safe 40 mg per day dosage and not go beyond 80 mg dosage. More importantly, though PQQ is known to be well-tolerated by the body, it is best to consult a doctor before beginning its intake if you have any preexisting conditions.
Pyrroloquinoline Quinone (PQQ) Uses
Pyrroloquinoline Quinone (PQQ) was initially thought to be a vitamin. However, further research established it as a non-vitamin compound that occurs in both the diet as well as mammalian tissue. However, it is important to highlight that though no research has verified its mammalian synthesis, about 100-400 nanograms of PQQ is formed in the human body every day. Unfortunately, this amount is not enough to support the various functions that PQQ has been proven to perform. Thus, human beings are often advised to consume PQQ in the form of dietary supplements.
A diet lacking in PQQ not only leads to reduced growth but also reduced sexual function. Similarly, several studies have linked PQQ with growth factor and mitochondrial biogenesis. In simple words, the human body can benefit from PQQ as it promotes the number and work of mitochondria, thereby leading to better energy levels. PQQ is also known to be an excellent REDOX agent and prevents self-oxidation and polymerization.
Best Pyrroloquinoline Quinone (PQQ) Supplement of 2020
Jarrow Formulas is a Los Angeles, California-based company that has been in the market since 1977 and is known for its high-quality products. The Jarrow Formulas Pyrroloquinoline Quinone (PQQ) supplement bottle contains 30 capsules, with each capsule providing 20 mg of PQQ. The best thing about this supplement is that it is gluten-free and contains no common allergens. Thus, people susceptible to different kinds of allergens can take this supplement without losing their peace of mind. However, these capsules contain gelatin and therefore, they are not to be taken by those who are vegan and vegetarian by choice. However, even with this one negative point, the Jarrow Formulas PQQ supplement is one of the best Pyrroloquinoline Quinone supplements currently available in the market. If you are looking for a vegetarian alternative, we recommend buying the Now Foods PQQ Energy supplement.
Where to Buy Pyrroloquinoline Quinone (PQQ) Powder in Bulk?
If you are a health supplements manufacturer involved in the manufacturing of Pyrroloquinoline Quinone on a large-scale, it is obvious that you must be looking for a raw materials supplier that can provide you with PQQ powder in bulk. Finding a supplier who can be trusted for quality and reliability is key to setting up a successful business.
If you are looking to buy Pyrroloquinoline Quinone (PQQ) powder in bulk, the best place to shop is Cofttek. Cofttek is a high-tech pharmaceutical biochemical enterprise that was established in 2008 and operates on the principle of “Quality Basis, Customer First, Honest Service, Mutual Benefit”. The company is committed to perfect testing, which allows it to provide high-quality services and products to its customers. Cofttek currently supplies its products to pharmaceutical companies in China, Europe, India and North America. The PQQ powder supplied by the company comes in batches of 25 kilograms, which is enough to produce multiple batches of your product. More importantly, Cofttek has an experienced management team and a first-class R&D team. You can, therefore, rest assured that you will get all your deliveries of incredibly high-quality products in a timely fashion. If you are looking to buy Pyrroloquinoline Quinone in bulk, contact the team at cofttek service.
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(2) Examine:Summary of Pyrroloquinoline quinone.
(3) Wikipedia:Pyrroloquinoline quinone.
(4) ScienceDirect:Pyrroloquinoline Quinone.