Cofttek is a professional company that has been in the market since 2012 and is known for its high-quality products.The best thing about this supplement is that it is gluten-free and contains no common allergens. Thus, people susceptible to different kinds of allergens can take this supplement without losing their peace of mind. the Cofttek PQQ supplement is one of the best Pyrroloquinoline Quinone supplements currently available in the market. If you are looking for a vegetarian alternative, we recommend buying the PQQ Energy supplement from Cofttek.

What is Pyrroloquinoline Quinone (PQQ)?

Pyrroloquinoline Quinone or PQQ is a compound that exists in plants as well as many bacteria and single-cell eukaryotes, such as yeast. PQQ also exists naturally in human breast milk as well as fermented soybeans, kiwi, papaya, spinach, parsley, oolong, green pepper and green tea. Research done on animals has linked insufficient PQQ or PQQ shortage with a compromised immune response, growth impairment, abnormal reproductive performance and reduced metabolic flexibility.


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For many years, researchers thought Pyrroloquinoline Quinone (PQQ) is a type of vitamin. However, research done over the last few years has revealed that Pyrroloquinoline Quinone is a nutrient with vitamin-like qualities that has the capacity to act as a co-factor or enzyme booster in the reduction-oxidation process which involves the transfer of electrons between two species. In simple words, PQQ binds itself with quinoproteins present in the body and works in collaboration with them to get rid of the free radicals. A research study found quinoproteins to be 100 times more effective than Vitamin – C as an anti-oxidant. Recent studies have also revealed that PQQ affects energy transfer and cellular metabolism by increasing the total number of mitochondria within the body. It is these important facts that have caused a sudden rise in the popularity of Pyrroloquinoline quinone in recent years.

What does pyrroloquinoline quinone do?

In addition to being a plant growth factor and bacterial cofactor, pyrroloquinoline quinone (PQQ) protects the mitochondria from oxidative stress and promotes mitochondriogenesis.

How much PQQ should you take daily?

So far no upper or lower limit has been established on Pyrroloquinoline Quinone (PQQ) dosage. However, results inferred from animal studies reveal that this compound becomes bioactive when taken in doses as low as 2 mg. However, most dietary supplements these days are available in the range of 20 mg to 40 mg, which is considered to be a safe range. PQQ is mostly available in the form of capsules, which people are advised to take on an empty stomach. However, users are advised to not go beyond 80 mg dosage per day.

When should I take CoQ10 morning or night?

It should be noted that taking CoQ10 close to bedtime may cause insomnia in some people, so it’s best to take it in the morning or afternoon ( 41 ). CoQ10 supplements can interact with some common medications, including blood thinners, antidepressants and chemotherapy drugs


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What does the Q stand for in CoQ10?

Coenzyme Q10 (CoQ10) is an antioxidant that your body produces naturally. Your cells use CoQ10 for growth and maintenance.

How can mitochondria be revived?

In response to stimuli, mitochondria undergo fusion/fission cycles to adapt to environment. It is thus logical to hypothesize that the plasticity of mitochondrial dynamics is required for neuronal regeneration.

Does CoQ10 have quinine in it?

Coenzyme Q10 belongs to a family of substances called ubiquinones which are structurally related to the chemical quinine. If you are certain that you are allergic to quinine, you should speak to your doctor prior to beginning daily supplementation with CoQ10.

Why did they take quinine off the market?

The US Food and Drug Administration (FDA) has ordered the removal of unapproved drug products containing quinine, citing serious safety concerns and deaths associated with their use. The action is part of a larger effort to remove all unsafe, unapproved drugs from the market.


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What is the best form of coenzyme Q10?

Ubiquinol accounts for 90% of the CoQ10 in the blood and is the most absorbable form. Thus, it’s recommended to choose from supplements containing the ubiquinol form.

What does Co Q 10 do for the body?

CoQ10 has been shown to help improve heart health and blood sugar regulation, assist in the prevention and treatment of cancer and reduce the frequency of migraines. It could also reduce the oxidative damage that leads to muscle fatigue, skin damage and brain and lung diseases.

Does PQQ cross the blood brain barrier?

Abstract. Pyrroloquinoline quinone (PQQ), otherwise known as methoxatin, is a water-soluble, redox-cycling orthoquinone that was initially isolated from cultures of methylotropic bacteria. … It appears that in the whole animal, however, PQQ does not cross the blood-brain barrier.

Why We Need Pyrroloquinoline Quinone (PQQ)?

As people age, their brain becomes compelled to battle multiple sources of damage. While some sources of damage register zero to minimal effect on the human brain, certain damages become a contributory factor to neurodegenerative disorders and progressive injuries that affect the blood vessels. In recent years, people have become more concerned about brain health and thus, the research, as well as awareness around brain function and health, has significantly intensified. Researchers are continually conducting studies to study and analyze the effect of various chemicals and compounds on the health of the human brain. One such compound which has evoked the interested of researchers and scientists around the world is Pyrroloquinoline Quinone (PQQ). In this article, we discuss everything there is to know about Pyrroloquinoline Quinone, including its function, benefits, dosage limitations and side effects. So, read on.


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Decrease toxin exposure. Provide nutrients that protect the mitochondria from oxidative stress.

Utilize nutrients that facilitate mitochondrial ATP production.

Can you increase mitochondria?

Physical exercise is the best way to increase your oxygen intake, critical for mitochondria’s Krebs cycle. As your body uses up more energy, it will force itself to produce more mitochondria to keep up with the demand.

Is PQQ quinine?

Pyrroloquinoline quinine, also known as PQQ, is a redox cofactor and a polyphenolic compound usually found in food plants. It is found in the cytoplasm of cells and helps with reduction reactions and oxidation.

What is quinine naturally found in?

Quinine is a bitter compound that comes from the bark of the cinchona tree. The tree is most commonly found in South America, Central America, the islands of the Caribbean, and parts of the western coast of Africa. Quinine was originally developed as a medicine to fight malaria.

What does Pyrroloquinoline Quinone disodium salt (PQQ) stand for?

A pre-qualification questionnaire (PQQ, sometimes referred to as a supplier assessment questionnaire) sets out a series of questions for potential tenderers to answer regarding their level of experience, capacity and financial standing.

What is the difference between coQ10 and ubiquinol?

Pyrroloquinoline quinone (PQQ) is a water-soluble quinone compound that has a strong anti-oxidant capacity. A previous study in rats fed a PQQ-depleted diet showed that elevated levels of serum triglyceride (TG) decreased after PQQ supplementation.


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Is PQQ safe?

Research done so far has established that PQQ is well-tolerated by the body when taken within the prescribed limits. However, exceeding the prescribed dosage can lead to side-effects, such as headaches, fatigue, and drowsiness. Thus, users are advised to stick to the safe 40 mg per day dosage and not go beyond 80 mg dosage. More importantly, though PQQ is known to be well-tolerated by the body, it is best to consult a doctor before beginning its intake if you have any preexisting conditions.

Is PQQ better than CoQ10?

CoQ10 is like a supercharger that improves the speed of the train. PQQ is like a construction company that is always working to add additional cars to your train. In summary, CoQ10 improves the speed of your energy production train, while PQQ is adding and building additional capacity to your train.

How much CoQ10 should I take?

There is no established ideal dose of CoQ10. Studies have used doses of CoQ10 ranging from 50 milligrams to 1,200 milligrams in adults, sometimes split into several doses over the course of a day. A typical daily dose is 100 milligrams to 200 milligrams.

Does CoQ10 cause blood clots?

Anticoagulants. CoQ10 might make blood-thinning drugs, such as warfarin (Jantoven), less effective. This could increase the risk of a blood clot.

Why is Q10 so expensive?

When, then, the Q10 passes from the blood into the cells and into the tissues, it is converted back to its bio-energetic form, ubiquinone. The ubiquinol form of Q10 is very unstable and, consequently, much more expensive for the Q10 capsule manufacturer to work with.

How long does CoQ10 take to work?

As Ubiquinol levels start to be restored in the blood plasma, many people should see reduced signs of fatigue on about the fifth day after starting the supplement. Usually within two to three weeks, your body’s amount of Ubiquinol will reach optimum levels, and many will feel a difference in energy within this time.


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What are the side effects of taking CoQ10?

CoQ10 supplements appear to be safe and to produce few side effects when taken as directed.

Mild side effects might include digestive problems such as:

  • Upper abdominal pain
  • Loss of appetite
  • Nausea and vomiting
  • Diarrhea

Other possible side effects may include:

  • Headaches and dizziness
  • Insomnia
  • Fatigue
  • Skin itching or rashes
  • Irritability or agitation

The safety of use of CoQ10 during pregnancy and breast-feeding hasn’t been established. Don’t use CoQ10 if you’re pregnant or breast-feeding without your doctor’s approval.

Is pyrroloquinoline quinone same as quinine?

Pyrroloquinoline quinine, also known as PQQ, is a redox cofactor and a polyphenolic compound usually found in food plants. PQQ can be consumed as a dietary supplement to aid cellular energy production and mitochondrial health and to defend the body against oxidative stress.

Is PQQ good for the heart?

Powerful Nutrient PQQ Can Prevent Heart Failure. Brand new clinical research, published in the latest edition of Cardiovascular Diagnosis & Therapy, concludes that the essential nutrient Pyrroloquinoline Quinone (PQQ) can play a role in the prevention of chronic heart failure (CHF).

Can you take PQQ while pregnant?

Our results suggest that supplementation with PQQ, particularly during pregnancy and lactation, protects offspring from WD-induced developmental programming of hepatic lipotoxicity and may help slow the advancing epidemic of NAFLD in the next generation.


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Is PQQ safe for diabetics?

These anti-diabetic effects of PQQ were supported by its antioxidative properties, as PQQ not only inhibited tissue LPO but also enhanced the serum insulin and HDL, as well as cellular antioxidants.

How do you energize mitochondria?

  • 10 Ways to Boost Your Mitochondria
  • Eat fewer calories.
  • Taking PQQ Supplements.
  • Throw away refined carbs like soda, white bread and pastries.
  • Eat quality protein like grass-fed beef and pasture-raised eggs
  • Prioritize getting 8 hours of sleep every night.
  • Reduce stress with relaxation techniques like meditation or massage daily.
  • Try heat therapy.
  • Get at least 30 minutes of activity daily.
  • Eat antioxidant-rich foods with resveratrol like dark chocolate.
  • Eat sources of omega-3s and alpha-lipoic acid.

What is PQQ antioxidant?

Pyrroloquinoline quinone (PQQ) is a novel redox cofactor recently found in human milk. PQQ was an effective antioxidant protecting mitochondria against oxidative stress-induced lipid peroxidation, protein carbonyl formation and inactivation of the mitochondrial respiratory chain.

What is vitamin PQQ?

PQQ is a natural compound found in a variety of foods. It acts as an antioxidant and supports healthy mitochondrial function. It’s taken as a supplement to promote brain function.


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What is PQQ 20?

Pyrroloquinoline quinone or PQQ is a recently discovered vitamin-like compound that is commonly found in plant foods. It was first discovered as a cofactor for bacteria that is similar to how B Vitamins effect humans. PQQ has antioxidant and B-vitamin-like activity, with a wide range of benefits for the brain and body.

What foods contain PQQ?

You probably eat a little PQQ every day. It’s found in small amounts in many foods like spinach, green peppers, kiwifruit, tofu, natto (fermented soybeans), green tea, and human milk. However, we generally don’t get a lot of PQQ from food — just an estimated 0.1 to 1.0 milligrams (mg) per day.

What foods increase mitochondria?

Some of these key nutrients include L-carnitine and creatine, which are both vital for supplying energy to mitochondria. You can get plenty of both by adding grass-fed beef, bison, eggs, poultry, beans, nuts, and seeds to your diet.

Does fasting increase mitochondria?

The study found that fasting enhances mitochondrial coordination with peroxisomes, a type of organelle that can increase fatty acid oxidation, a fundamental fat metabolism process.

What exercises increase mitochondria?

A new study found that exercise — and in particular high-intensity interval training in aerobic exercises such as biking and walking — caused cells to make more proteins for their energy-producing mitochondria and their protein-building ribosomes, effectively stopping aging at the cellular level.

Can you repair damaged mitochondria?

It has been determined that to counteract damage, mitochondria possess well-defined repair pathways quite similar to those of the nucleus, among which are: base excision repair (BER), mismatch repair (MMR), single-strand break repair (SSBR), microhomology-mediated end joining (MMEJ), and probably homology recombination.


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What supplements increase mitochondria?

Oral natural supplements containing membrane phospholipids, CoQ10, microencapsulated NADH, l-carnitine, α-lipoic acid, and other nutrients can help restore mitochondrial function and reduce intractable fatigue in patients with chronic illnesses.

Pyrroloquinoline Quinone (PQQ) Uses

Pyrroloquinoline Quinone (PQQ) was initially thought to be a vitamin. However, further research established it as a non-vitamin compound that occurs in both the diet as well as mammalian tissue. However, it is important to highlight that though no research has verified its mammalian synthesis, about 100-400 nanograms of PQQ is formed in the human body every day. Unfortunately, this amount is not enough to support the various functions that PQQ has been proven to perform. Thus, human beings are often advised to consume PQQ in the form of dietary supplements.

A diet lacking in PQQ not only leads to reduced growth but also reduced sexual function. Similarly, several studies have linked PQQ with growth factor and mitochondrial biogenesis. In simple words, the human body can benefit from PQQ as it promotes the number and work of mitochondria, thereby leading to better energy levels. PQQ is also known to be an excellent REDOX agent and prevents self-oxidation and polymerization.

Pyrroloquinoline Quinone (PQQ)Benefits

The interest in Pyrroloquinoline Quinone has increased considerably during the last few years as this compound has been linked with several benefits. Here, we look at its most important Pyrroloquinoline Quinone (PQQ) benefits.

① PQQ Has Been Linked with Improved Overall Energy

Mitochondria are tiny organelles that exist within the cells and are often referred to as cell powerhouses as they release energy from food, thereby providing the energy the cells need to do their function. Pyrroloquinoline Quinone allows mitochondria to work better, thereby leading to increased energy production within the cells. This increased energy within the cells eventually finds its way to the entire body, in turn leading to more stamina and overall energy. If you often experience lethargy or low energy, PQQ supplements will help you boost your energy levels. (1)Pubmed:Effects of Pyrroloquinoline Quinone (PQQ)

② It Improves Nerve Growth Factors

Pyrroloquinoline Quinone interacts with cellular pathways and in the process, invariably positively affects nerve growth factors. This, in turn, leads to enhanced development of neuronal cells and nerves in the cranial tissue. Thus, PQQ is often linked with improved brain function. Since NGF dysregulation is often linked with Alzheimer’s disease, PQQ supplements are often prescribed to aid the treatment of age-related conditions.

③PQQ Intake Has Been Linked with Improved Sleep

A study analyzed the effect of PQQ intake on people’s sleep. The study analyzed participants over a period of eight weeks and found that those who regularly consumed for eight weeks were able to sleep better. The study also revealed that PQQ intake reduces cortisol, the stress hormone that interrupts with normal sleep. Though more research is needed in this particular area, preliminary research clearly links PQQ intake with improved sleep.


④ PQQ Promotes Overall Well-Being by Reducing Oxidative Stress

PQQ is known for its high anti-oxidant properties — it decreases the level of C-reactive protein and IL-6 within the body, both of which are responsible for inflammation. Its oxidative properties also make PQQ an effective fighter against oxidative stress, which is a common cause of several chronic diseases, such as carcinomas and neurodegenerative diseases. PQQ reduces stress by reducing the oxidative damage caused by free radicals and enhancing metabolism.


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⑤ PQQ in Combination with CoQ10 Improves Memory Function

PQQ intake has been linked with reduced stress, which in turn, leads to enhanced cognitive function and improvements to memory. Research studies have been conducted to study how PQQ affects memory. A research study found that PQQ works in collaboration with CoQ10, a coenzyme that works as an antioxidant that boosts metabolism and protects cells from damage. PQQ in combination with CoQ10 has shown to improve memory function.

⑥ Other Benefits of PQQ

Over and above the aforementioned benefits, PQQ also offers some other benefits the research on which is currently underway. For instance, preliminary research has proven that PQQ intake also leads to improved fertility.

Where to Buy Pyrroloquinoline Quinone (PQQ)Powder in Bulk?

If you are a health supplements manufacturer involved in the manufacturing of Pyrroloquinoline Quinone on a large-scale, it is obvious that you must be looking for a raw materials supplier that can provide you with PQQ powder in bulk. Finding a supplier who can be trusted for quality and reliability is key to setting up a successful business.

If you are looking to buy Pyrroloquinoline Quinone (PQQ) powder in bulk, the best place to shop is Cofttek. Cofttek is a high-tech pharmaceutical biochemical enterprise that was established in 2008 and operates on the principle of “Quality Basis, Customer First, Honest Service, Mutual Benefit”. The company is committed to perfect testing, which allows it to provide high-quality services and products to its customers. Cofttek currently supplies its products to pharmaceutical companies in China, Europe, India and North America. The PQQ powder supplied by the company comes in batches of 25 kilograms, which is enough to produce multiple batches of your product. More importantly, Cofttek has an experienced management team and a first-class R&D team. You can, therefore, rest assured that you will get all your deliveries of incredibly high-quality products in a timely fashion. If you are looking to buy Pyrroloquinoline Quinone in bulk, contact the team at cofttek service.

Pyrroloquinoline Quinone (PQQ) infogram 01
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Article by:Dr. Zeng

Article by:

Dr. Zeng

Co-founder, the company’s core administration leadership; PhD received from Fudan University in organic chemistry. More than nine years of experience in organic chemistry and drug design synthesis; nearly 10 research papers published in authoritative journals, with more than five Chinese patents.


(1)Pubmed:Effects of Pyrroloquinoline Quinone (PQQ) Supplementation on Aerobic Exercise Performance and Indices of Mitochondrial Biogenesis in Untrained Men

(2)The neuroprotective effect of pyrroloquinoline quinone on traumatic brain injury

(3)Recent progress in studies on the health benefits of pyrroloquinoline quinone

(4)Effect of the Antioxidant Supplement Pyrroloquinoline Quinone Disodium Salt (BioPQQ™) on Cognitive Functions

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Dr. Zeng Zhaosen


Co-founder, the company’s core administration leadership; PhD received from Fudan University in organic chemistry. More than nine years of experience in organic synthesis field of medicinal chemistry. Rich experience in combinatorial chemistry, medicinal chemistry and custom synthesis and project management.

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