Urolithin powder

Cofftek have the capability to mass production and supply of urolithin a , urolithin b and Methylurolithin A under the condition of cGMP.

What are Urolithins?

Urolithins are derivatives or metabolites of ellagic acid components such as ellagitannins. These chemical components are metabolized from ellagic acid-derivatives by the gut microbiota.

Since the intestinal flora is crucial for the production of urolithins, the amount of urolithins produced in the body depends on the type of organisms in the flora, the most important organism belonging to the Clostridium leptum group. It is reported that people with microbiota rich in members of this group produce a significantly higher number of urolithins than those with other gut flora such as Bacteroides or Prevotella.

Urolithins are also produced from punicalagin in the gut, exactly like ellagitannins, and then excreted out in the urine. To check for urolithin production in the body, their levels need to be checked in the urine of the person who has consumed foods rich in ellagic acid or supplements with urolithins as their main ingredient. Urolithin, once in the plasma, can be detected in the form of glucuronides.

Urolithins are naturally available in several foods, although not all molecules of urolithins can be derived from food. Once foods rich in ellagic acid have been ingested, it depends on the gut flora to break down ellagitannins and punicalagin further into intermediate metabolites and the end products; urolithin molecules.

These molecules recently gained popularity and continue to rise as superfood supplements due to their anti-tumor, anti-aging, anti-inflammatory, and autophagy-inducing benefits. Moreover, specific urolithin molecules are associated with improved energy levels as they have a huge impact on mitochondrial health. Energy production in the body is a process that occurs in the mitochondria, and improving the functioning of this organelle is one of the many functions of Urolithins.

Known Molecules of Urolithin

Urolithins refer collectively to different molecules that belong to the urolithin family but have different chemical formulas, IUPAC names, chemical structures, and sources. Moreover, these molecules have widely different uses and benefits on the human body and hence are advertised differently in the supplement form.

Urolithins, after extensive research, is known to breakdown into the following molecules in the body, although not much is known about every specific molecule:

●Urolithin A (3,8-Dihydroxy Urolithin)
●Urolithin A glucuronide
●Urolithin B (3-Hydroxy Urolithin)
●Urolithin B glucuronide
●Urolithin D (3,4,8,9-Tetrahydroxy Urolithin)

Urolithin A and Urolithin B, more commonly known as UroA and UroB respectively, are the well-known metabolites of Urolithins in the body. These two are also the molecules that are currently being used in the supplements and meal replacement powders.

Once in the blood, Urolithin A is present as Urolithin A glucuronide, and Urolithin B can be detected as Urolithin B glucuronide. Because of this, it is believed that they have the same effects as their precursors as in vivo studies have not been possible with urolithins. The lack of in vivo studies makes it difficult to assess if the UroA and UroB glucuronides have any effect different from UroA and UroB themselves.

Urolithin A has another derivative that can be detected in the blood, namely, Urolithin A sulfate. All these derivatives perform their functions in the blood and are then cleared out of the system through urine.

Urolithin D is another important molecule that is produced by the effects of the gut microbiota, however, not much is known about its effects and potential uses. Currently, it is not being used in any supplements or meal replacements, unlike its counterparts, UroA and UroB. Moreover, dietary sources of Urolithin D are not known.

Urolithin A Powder Information Package

Urolithin A is not available naturally from food sources and belongs to the group of compounds known as benzo-coumarins or dibenzo-α-pyrones. It is actually metabolized from ellagitannins to Urolithin A 8-Methyl Ether before being further broken down into Urolithin A. This end product is available in bulk at our manufacturing factory in the form of Urolithin A powder. MethylUrolithin A powder is also available to purchase in bulk if needed.

Urolithin A is not available in the same levels, even with the same levels of consumption of its precursors, in different people because it is all dependent on the activity of gut microbiota. Urolithin A’s metabolism is believed to require Gordonibacter urolithinfaciens and Gordonibacter pamelaeae but some people with these still show minimal to no effect on the production of the molecule.

Urolithin A has specific features that make it stand out from other components, like those mentioned in the table below.

CAS Number1143-70-0
Purity98%
IUPAC name3,8-Dihydroxybenzo[c]chromen-6-one
Synonyms3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one; 3,8-DIHYDRO DIBENZO-(B,D)PYRAN-6-ONE; 3, 8-Dihydroxy-6H-benzo[c]chromen-6-one; Castoreum pigment I; Urolithin A; 6H-Dibenzo(B,D)pyran-6-one, 3,8-dihydroxy-; 3,8-dihydroxy-6H-dibenzopyran-6-one); urolithin-A(UA;3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one
Molecular FormulaC13H8O4
Molecular Weight228.2
Melting Point>300 °C
InChI KeyRIUPLDUFZCXCHM-UHFFFAOYSA-N
FormSolid
AppearanceLight Yellow powder
Half-LifeNot known
SolubilitySoluble in DMSO (3 mg/mL).
Storage ConditionDays to Weeks: In a dark, dry room at 0 – 4 degrees C Months to Years: In a Freezer, away from liquids at -20 degrees C.
ApplicationDietary uses as a meal replacement and supplements

Urolithin B Powder Information Package

Urolithin B is a phenolic compound that has only begun to be mass-produced since January of 2021. It can be obtained by eating several foods that are natural sources of ellagitannins that can be metabolized into Urolithin B. It has been found to be a potent anti-aging compound that you can buy in bulk in the form of Urolithin B powder.

The different properties of the Urolithin B powder available at our manufacturing company are mentioned below:

CAS Number1139-83-9
Purity98%
IUPAC name3-Hydroxy-6H-dibenzo[b,d]pyran-6-one
SynonymsAURORA 226; Urolithin B; AKOS BBS-00008028; 3-hydroxy urolithin; 3-hydroxy-6-benzo[c]chromenone;3-hydroxybenzo[c]chromen-6-one; 3-Hydroxy-benzo[c]chromen-6-one; 3-HYDROXY-6H-DIBENZO[B,D]PYRAN-6-ONE; 6H-Dibenzo(b,d)pyran-6-one, 3-hydroxy-;3-Hydroxy-6H-benzo[c]chromen-6-one AldrichCPR
Molecular FormulaC13H8O3
Molecular Weight212.2 g/mol
Melting Point>247 °C
InChI KeyWXUQMTRHPNOXBV-UHFFFAOYSA-N
FormSolid
AppearanceLight brown powder
Half-LifeNot known
SolubilitySoluble at 5mg/mL when warmed, clear liquid
Storage Condition2-8°C
ApplicationAnti-oxidant and Pro-oxidant supplement with estrogenic activity.


Apart from these main molecules of Urolithins that are formed as a result of gut flora’s actions, there are several molecules that are intermediates formed during the breakdown of the precursors. These intermediates include:

●Urolithin M-5
●Urolithin M-6
●Urolithin M-7
●Urolithin C (3,8,9-Trihydroxy urolithin)
●Urolithin E (2,3,8,10-Tetrahydroxy urolithin)

Not much is known about these intermediates as of now, however, further research has the potential to discover the benefits and uses of these Urolithin molecules.

How do Urolithins Work?

Urolithins, like other compounds used in supplements, affect different organs and systems in the body, to produce their beneficial effects. The mechanism of action of Urolithins, both A and B, can be divided into six main branches, and each branch has the potential to produce multiple benefits.

●Antioxidant Properties
The main benefit of having antioxidant properties is reduced oxidative stress in the body. Oxidative stress refers to stress on the cells and tissues in the body as a result of chemical reactions that produce unstable compounds, also known as free radicals. These free radicals have further potential to participate in volatile chemical reactions in the body, the byproducts of which damage the cells and tissues.

Urolithins suppress this oxidative stress, which results in the inhibition of cell injury and increases the chances of cell survival. These effects are made possible through the reduction of the production of intracellular Reactive Oxygen Species (iROS), which are a type of free radicals. Moreover, antioxidant properties of Urolithin A and Urolithin B also arise through reduced NADPH oxidase subunit expression, which is crucial for the chemical reactions resulting in oxidative stress.

To produce the antioxidant properties, Urolithins also increase the expression of antioxidant heme oxygenase-1 via the Nrf2/ARE signaling pathway. This helps them not only reduce the harmful compounds but also increase the good enzymes which promote antioxidant properties.

Urolithins, when given to mice with LPS-induced brain damage, inhibited microglial activation, or in simpler terms, scar and inflammation formation which would increase the risk of permanent brain damage. This effect of urolithins is believed to be a blend of antioxidant properties and anti-inflammatory properties.

●Anti Inflammatory Properties
The anti-inflammatory properties of Urolithins are one of the main reasons for its rising fame in the supplement world. The mechanism through which these compounds, especially Urolithin A, Urolithin B, and their glucuronides form, are widely different and produce equally different results.

The anti-inflammatory effect of Urolithin A and Urolithin B has the same mechanism as Non-Steroidal Anti-inflammatory Drugs or NSAIDs such as Ibuprofen and Aspirin. Urolithins are known to have an inhibitory effect on the production of PGE2 and the expression of COX-2. As NSAIDs inhibit the expression of both COX 1 and COX 2, it can be concluded that Urolithins have a more selective anti-inflammatory effect.

The anti-inflammatory properties of Urolithins have been proven to not only fight inflammation in the body but are also able to reverse the damage done to the organs as a result of long-term inflammation which has resulted in organ failure. In a recent study performed on animal models, it was found that urolithin consumption had the ability to mitigate drug-induced nephrotoxicity by inhibiting renal cell death and inflammation.

It was found that urolithin A powder, given orally, had an inhibitory effect on the inflammation pathway along with the proapoptotic cascade, hence, protecting renal function. These properties of Urolithin A along with other urolithins points towards a future where these compounds may be used medicinally along with their current use as supplements.

●Anti-Carcinogenic Properties
Urolithins are believed to be anti-carcinogenic due to their ability to have effects such as cell cycle arrest, aromatase inhibition, induction of apoptosis, tumor suppression, promotion of autophagy, and senescence, transcriptional regulation of oncogenes, and growth factor receptors. These effects, if absent, can cause the aberrant growth of cancer cells. Preventive features of Urolithins have been proven, especially for prostate cancer and colon cancer, with many researchers rallying for the use of Urolithins as potential preventive medication for prostate cancer.

A study performed in 2018 studied the effects of Urolithin on the mTOR pathway with the aim of finding a treatment option for pancreatic cancer. Pancreatic cancer is associated with high mortality rates, but recent research shows that Urolithin may be able to not only increase the survival rate but also inhibit grafting of tumor cells to other parts of the body, resulting in metastasis. Urolithin A was studied specifically and the results were compared to the results produced by the standard treatment regimen. It was concluded that Urolithin A produced better results when used to manage pancreatic cancer, in both conditions; when used alone or with the standard treatment plan.

With further research, Urothilins benefits may conclusively contain treatment of pancreatic cancer as well.

●Antibacterial Properties
Urolithins are known for their antibacterial properties and they have this effect by inhibiting the communication channels of the microorganisms, not allowing them to move about or infect the cells. They are also believed to have antifungal properties, although the exact mechanism is not yet clear.

There are two pathogens that Urolithins have an especially strong inhibitory effect on, resulting in protection for the human body. These pathogens are malarial microbes and Yersinia enterocolitica, with both of them causing severe infections in humans. The mechanism through which Urolithins have antibacterial properties regardless of the organism is the same.

●Anti Estrogenic and Estrogenic Properties
Estrogen is an important hormone in the female body, and the decline in its levels is associated with symptoms such as flushing, hot flashes, and decreased bone mass. Given the importance of the hormone, it makes sense that a substitute is being actively searched. However, exogenous hormones have certain side effects that make their use undesirable.

However, Urolithin A and Urolithin B have the same structure as endogenous estrogen and an affinity for the estrogen receptors in the body. Urolithin A has a stronger affinity, especially for the alpha receptor compared to the beta receptor. Although both of these compounds have structural similarities with estrogen, urolithins have both estrogenic and anti-estrogenic properties, unlike endogenous estrogen.

The duality of this effect of Urolithins makes them a potential treatment option for certain disorders that arise when exogenous estrogen is given to treat the symptoms of estrogen deficiency.

●Protein Glycation Inhibition
Protein glycation is a process in which a sugar molecule is bound to a protein. This process is seen during aging or as a part of certain disorders. Urolithins inhibit the addition of sugar, hence inducing anti-glycation effects. Moreover, they inhibit advanced glycation endproducts formation, the accumulation of which is an important pathophysiological step in the development of diabetes.

Benefits of Urolithins

Urolithins have different mechanisms of action to produce different protective benefits in the human body. Urolithin A powder and Urolithin B powder help manufacture the supplements which are famous because of the benefits of the main ingredients. All the benefits of these chemical compounds are backed by scientific evidence, and even further research is being performed to support the addition of Urolithins in the guidelines for the treatment of several disorders.

The benefits of these compounds, based on the mechanisms mentioned above, include:

●Antioxidant Properties
Urolithins are extracted from several ellagitannins-rich foods that themselves are known to be rich in antioxidants. The most common food source for ellagitannins and ellagic acid is pomegranates, and they are also a great source of antioxidants. However, it is important to distinguish if the antioxidant properties of the food source and urolithins are similar or if one has a higher potential than the other.

Initial studies of Urolithin A and Urolithin B showed that the antioxidant effects of these were 42 times less than that of the fruit itself, hence implying that these chemical compounds would not make for good ingredients for supplements.

However, recent studies with a different method of analysis show that Urolithin A and B are both quite efficient and have potent antioxidant properties that will combat the effects of oxidative stress. When the same method of analysis was used to study all urolithins to see which is the most potent, Urolithin A stood out. The results were then reproduced in a similar study with Urolithin A taking the lead in potency, again.

In fact, one of the studies focused on assessing the antioxidant properties of these chemical compounds by testing their ability to fight oxidative stress. For the purpose of this study, researchers induced stress in neuronal cells and when exposed to Urolithins, specifically Urolithin B, they noticed a marked decrease in stress along with increased survivability of the neuronal cells.

●Anti Inflammatory Properties
The anti-inflammatory properties of Urolithins produce several benefits, all of which have been proven scientifically.

1.Antimalarial effect
A homemade remedy for malaria treatment that is widely used in certain rural areas involves the use of Pomegranate. Researchers attempted to understand the positive effect of this remedy on the treatment of malaria by associating the results with the effects of Urolithins metabolized in the gut from pomegranate.

A study was performed to study the effect of Urolithins in treating malaria by exposing infected monocytic cells to Urolithins. This study found that the chemical compounds inhibit the release of MMP-9, which is an important metalloproteinase in the development and pathogenesis of malaria. Inhibition of the compound inhibits malaria from being pathogenic in the body, hence why it is believed to have an antimalarial effect.

The results of the study also showed that Urolithins inhibited mRNA expression of malarial pathogens, resulting in further inhibition of the microorganisms’ ability to cause infection. The results of this study prove that the beneficial effects of homemade remedies including pomegranate is due to the effects of urolithin.

2.Effect on Endothelial Cells
Atherosclerosis is a common condition that leads to cardiac insults and myocardial infarctions. The two common factors behind atherosclerosis development are endothelial dysfunction and inflammation. Recent studies have tried to prove that the anti-inflammatory properties of Urolithin may be able to prevent endothelial dysfunction, and hence, manage atherosclerosis formation and development.

Urolithin A was found by researchers to have the highest anti-inflammatory action amongst all urolithins. A recent study focused on human endothelial cells that were incubated with oxidized LDL, a prerequisite for atherosclerosis formation, and different concentrations of Urolithin A. The researchers found that Urolithin A inhibited nitric oxide synthase and reduced the expression of I-CAM, which resulted in reduced inflammation and decreased ability of cells, especially monocytes to adhere to the endothelial cells, respectively. Reduced monocytic adherence alleviates endothelial dysfunction.

Moreover, Urolithin A was found to reduce the expression of tumor necrosis factor α, interleukin 6, and endothelin 1; all pro-inflammatory cytokines.

3.Effect on Fibroblasts in the Colon
Colon is exposed to exogenous pathogens and dietary components that make it vulnerable to inflammation, which in the long run can lead to several health issues. As Urolithin A and Urolithin B are produced by the intestinal flora, it is important to know their effects in the first place in the body they are formed.

To study the effects of Urolithins on colon cells and fibroblasts, researchers performed an experiment where fibroblasts were exposed to pro-inflammatory cytokines and then to Urolithins. As mentioned above, it was found that Urolithins inhibits monocyte adhesion and fibroblast migration to inhibit inflammation in the colon.

Moreover, it was found that Urolithins inhibited the activation of the NF-κB factor, which is important for the regulation of inflammation. In fact, researchers believe this to be the main factor behind the anti-inflammatory properties of urolithins.

●Anti-Carcinogenic Properties
Urolithins are associated with anti-cancer properties, and the mechanism of these properties is mentioned above. However, the benefits of these properties are mentioned below:

1.Protection from Prostate Cancer
Detection of Urolithins in the body is usually done either using the blood or urine; however, they can be detected in both the colon of males and females and the prostate gland of males.

As a result of this finding, researchers tried to assess if the benefits of the chemical compounds are visible in the prostate gland like they are in the colon. Hence, a study was designed, the results of which proved that Urolithins do have a protective effect on the prostate gland.

It was found that Urolithin A and Urolithin B, along with Urolithin C and Urolithin D inhibited the CYP1B1 enzyme in the prostate gland. This enzyme is the target of chemotherapy and it was strongly inhibited by Urolithin A, compared to other urolithins. They also inhibited CYP1A1, however, a higher concentration of urolithins was required to produce that effect.

Another study was performed to study the prostate protective effects of Urolithins. It was found that Urolithin A had an anti-cancer effect on prostate cancer through both, p53 dependant and p53 independent manner.

2.Topoisomerase 2 and CK 2 inhibition
Urolithins have anti-cancer properties through the inhibition of several molecular pathways which either directly or indirectly result in the inhibition of cancer growth. The CK2 enzyme is an important enzyme that participates in such molecular pathways, with its main function being to promote inflammation and cancer.

Urolithins inhibit different pathways to reach the ubiquitous enzyme, CK2 to eventually inhibit its effect, such as its cancer-promoting properties. Urolithin A has been shown to be a potent CK2 inhibitor, in silico.

Similarly, Topoisomerase 2 inhibition is believed to have anti-cancer effects. In fact, this mechanism is used by certain chemotherapy agents such as Doxorubicin. In a recent study, it was found that Urolithin A is more potent than Doxorubicin in inhibiting Topoisomerase 2, hence, calling for its addition to the current guidelines for the treatment of certain cancers.

●Antibacterial Properties
The antibacterial properties of Urolithins depend on Quorum Sensing Inhibition which takes away the ability of the microorganism to communicate, move, and form virulence factors. It is an important mechanism for the survival of bacteria, and its inhibition by Urolithins is deadly for the microorganism.

The main antibacterial property of Urolithin is its ability to protect the gut from the overgrowth of Yersinia enterocolitica. In fact, Urolithins are associated with modulation of the gut flora, the same flora which is responsible for their production in the first place. This is especially important as only specific organisms in the flora can increase the production of Urolithins.

●Anti Estrogenic and Estrogenic Properties
Urolithins bind to the Estrogen receptors and produce both, estrogenic and anti-estrogenic properties. This makes it a great candidate for Selective Estrogen Receptor Modulators or SERMs, the main mechanism of which is to have a positive effect in one area of the body and an inhibitory effect on the other area of the body.

In one of the studies performed on the effects of urolithins on estrogen receptors, it was found that they, especially urolithin A, inhibit the gene expression of ER-positive endometrial cancer cells, resulting in suppression of endometrial cancer. Endometrial hypertrophy is a common side effect of exogenous estrogen in post neoplasia like women taking hormone replacement therapy, and the use of urolithins is believed to have a protective effect on the endometrium. However, further research needs to be performed before Urolithins can become the next SERM medication.

●Protein Glycation Inhibition
The presence of advanced glycation end products is a hallmark of hyperglycemia that predisposes people to diabetes-associated cardiovascular injury or even Alzheimer’s disease. Urolithin A and Urolithin B have been shown to have an anti-glycation effect that prevents cardiac insults and reduces the risk of neurodegeneration significantly.

Hence, the inhibition of protein glycation by Urolithins is believed to have both cardioprotective and neuroprotective effects.

The benefits of Urolithin A specifically are mentioned below:

●Increase life span
Aging, stress, and certain disorders can damage the mitochondria, which is crucial for normal energy production and use in the body. Moreover, mitochondria are often referred to as the ‘powerhouse of the cell’, which implies its importance for the normal functioning of the cell. Hence, any damage to this powerhouse would negatively affect the cell and reduce its lifespan significantly.

Urolithins induce a specific effect known as mitophagy which allows the body to remove damaged mitochondria, regardless of the reason for the damage, and increase the life span. Based on the extent of damage, mitochondria may be recycled for nutrients and energy production.

●Neuroprotective
As mentioned above, urolithins have anti-inflammatory properties and it is these properties that promote neuronal cell formation in the brain, which has a positive effect on cognition and memory retention. Moreover, Urolithin A protects against neurodegeneration seen with Alzheimer’s disease, hence, the neuroprotective effects.

●Prevent Prostate Cancer
Urolithin A has anti-cancer properties but they are especially visible in the case of prostate cancer, with several studies promoting the use of pomegranate and other sources of Urolithins for the treatment of Prostate cancer.

●Treat Obesity
Urolithin A has anti-obesity effects as it not only inhibits the accumulation of fat cells in the body but also inhibits the markers responsible for adipogenesis. In a study performed on animal models, it was found that Urolithin A has an elevating effect on T3 thyroid hormone, which results in increased energy expenditure in the mice. This induces thermogenesis and causes brown fat to melt, while white fat is being induced into browning.

In the same study, it was found that URolithin A has a preventive effect on obesity even in mice who were fed a high-fat diet. This shows great promise as far as obesity is concerned and the researchers have called for human applications of these findings to be able to potentially use this compound to fight the obesity pandemic.

The benefits of Urolithin B are as below:

●Prevent muscle loss
Urolithin B shares some of the benefits of Urolithin A but has one specific benefit, unique only to itself. Urolithin B is known to prevent muscle loss in both physiological and pathological states. Moreover, it promotes skeletal muscle growth by increasing protein synthesis in the muscles.

It also has a preventive effect on muscle atrophy as seen in a study performed on mice who had had their sciatic nerve severed. This would have led to muscle atrophy but the mice were implanted with mini osmotic pumps that continuously gave them Urolithin B. It was found that these mice have their ubiquitin-proteasome pathway repressed, which led to a clear lack of muscle atrophy despite sciatic nerve sectioning.

Dosage of Urolithins

Urolithins are derived from natural compounds and their supplements are considered to be well-tolerated with no toxicities reporter. However, it is important to keep in mind that these compounds are still under research and have dosage limits that should be strictly followed.

●Urolithin A
After extensive research on the benefits of Urolithin A, there were several research studies performed to assess the right dosage of this chemical compound. The Absorption, Digestion, Metabolism, and Elimination study was performed to analyze the features of the compound.

The study was divided into two, depending on the number of days, and it was found that the 28-day study with 0, 0.175, 1.75, and 5.0% of Urolithin A mixed in diet and 90-day study with 0, 1.25, 2.5, and 5.0% Urolithin A mixed in the diet showed no alterations in clinical parameters, blood chemistry, or hematology, and did not imply any specific toxic mechanisms. Both studies had the highest dose tested at 5% UA by weight in the diet which led to the following dosages; 3451 mg/kg BW/day in males and 3826 mg/kg BW/day in females in the 90-day oral study.

●Urolithin B
Similar to Urolithin A, Urolithin B was studied extensively to assess the perfect dosage. Although it is important to note that the studies focused on the safe dosage to achieve optimal muscle increase. This dose was found to be 15uM, for both genders, regardless of the weight.

●Urolithin A 8-Methyl Ether
This compound is used as well, mainly because it is an intermediate during Urolithin A production. However, not enough research has been performed for an appropriate dosage to be determined for this specific Urolithin.

Food Sources of Urolithins

Urolithins are not found naturally in any food source, however, they are found as ellagitannins. These tannins break down into ellagic acid, which further metabolizes into Urolithin A 8-Methyl ether, then into Urolithin A, and finally, Urolithin B. The foods that are rich in Urolithins are:

Dietary sourceEllagic Acid
Fruits (mg/100g fresh weight)
Blackberries150
Black raspberries90
Boysenberries70
Cloudberries315.1
Pomegranate>269.9
Raspberries270
Rose hip109.6
Strawberries77.6
Strawberry jam24.5
Yellow raspberries1900
Nuts (mg/g)
Pecans33
Walnuts59
Beverages (mg/L)
Pomegranate juice811.1
Cognac31-55
Oak-aged red wine33
Whiskey1.2
Seeds (mg/g)
Black raspberries6.7
Red raspberries8.7
Boysenberries30
Mango1.2


As seen in the table, Cloudberries are the fruit with the highest Ellagitannins and Ellagic acid, with Pomegranate as a close second. Pomegranate Juice, however, is actually a more potent source, almost three times as potent as Cloudberries.

It is important to note that the content of ellagic acid in the dietary resources doesn’t equate to the same amount of urolithin in the body. The bioavailability of the URolithins is highly dependent on the gut microbiota of every individual.

Why Should You Buy From Our Manufacturer Factory?

Urolithin Powder A and Urolithin Powder B are available in bulk, at our manufacturing factory that integrates production, research, development, and sales of such supplements. Our products are manufactured using extreme precision to follow all safety guidelines, which ensures the high quality and safety of the final product. All products are researched prior to manufacturing and are thoroughly tested during and after production to meet your quality standards.

After production, products are tested at our labs one more time to check for the quality, potency, and safety of the Urolithin powders and other products. Once ready for distribution, the products are packed and stored in appropriate facilities, at the right temperature while following all guidelines to guarantee that high-quality product reaches you. Urolithin powders are not exposed to sunlight during transport, packaging, or storage as that could damage the end product.

Buying Urolithin A powder and Urolithin B powder from our manufacturer factory guarantees a high-quality product at very affordable prices.

Reference:

  1. Totiger TM, Srinivasan S, Jala VR, et al. Urolithin A, a Novel Natural Compound to Target PI3K/AKT/mTOR Pathway in Pancreatic Cancer. Mol Cancer Ther. 2019;18(2):301-311. doi:10.1158/1535-7163.MCT-18-0464.
  2. Guada M, Ganugula R, Vadhanam M, Ravi Kumar MNV. Urolithin A Mitigates Cisplatin-Induced Nephrotoxicity by Inhibiting Renal Inflammation and Apoptosis in an Experimental Rat Model. J Pharmacol Exp Ther. 2017;363(1):58-65. doi:10.1124/jpet.117.242420.
  3. Juan Carlos Espín, Mar Larrosa, María Teresa García-Conesa, Francisco Tomás-Barberán, "Biological Significance of Urolithins, the Gut Microbial Ellagic Acid-Derived Metabolites: The Evidence So Far", Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 270418, 15 pages, 2013. https://doi.org/10.1155/2013/270418.
  4. Lee G, Park JS, Lee EJ, Ahn JH, Kim HS. Anti-inflammatory and antioxidant mechanisms of urolithin B in activated microglia. Phytomedicine. 2019;55:50-57. doi:10.1016/j.phymed.2018.06.032.
  5. Han QA, Yan C, Wang L, Li G, Xu Y, Xia X. Urolithin A attenuates ox-LDL-induced endothelial dysfunction partly by modulating microRNA-27 and ERK/PPAR-γ pathway. Mol Nutr Food Res. 2016;60(9):1933-1943. doi:10.1002/mnfr.201500827.