Alpha Lipoic Acid (ALA) (1077-28-7) Specifications
| Name: | Alpha Lipoic Acid (ALA) |
| CAS: | 1077-28-7 |
| Purity | 98% |
| Molecular Formula: | C8H14O2S2 |
| Molecular Weight: | 206.33 g/mol |
| Melt Point: | 60–62 °C (140–144 °F; 333–335 K) |
| Chemical name: | (R)-5-(1,2-Dithiolan-3-yl)pentanoic acid;
α-Lipoic acid; Alpha lipoic acid; Thioctic acid; 6,8-Dithiooctanoic acid |
| Synonyms: | (±)-α-Lipoic acid, (±)-1,2-Dithiolane-3-pentanoic acid, 6,8-Dithiooctanoic acid, DL -α-Lipoic acid, DL -6,8-Thioctic acid, Lip(S2) |
| InChI Key: | AGBQKNBQESQNJD-UHFFFAOYSA-N |
| Half Life: | Half life of orally administered ALA is merely 30 min |
| Solubility: | Very Slightly Soluble in water(0.24 g/L); Solubility in ethanol 50 mg/mL |
| Storage Condition: | 0 – 4 C for short term (days to weeks), or -20 C for long term (months) |
| Application: | Alpha-lipoic acid is used in the body to break down carbohydrates and to make energy for the other organs in the body. Alpha-lipoic acid seems to work as an antioxidant, which means that it might provide protection to the brain under conditions of damage or injury. |
| Appearance: | Yellow needle-like crystals |
Alpha Lipoic Acid (ALA) (1077-28-7) NMR Spectrum
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Alpha Lipoic Acid (ALA) (1077-28-7)?
Alpha-lipoic acid is a compound found naturally inside every cell of the human body. Its primary role is to convert blood sugar (glucose) into energy using oxygen, a process referred to as aerobic metabolism. Alpha-lipoic acid is also considered an antioxidant, meaning that it can neutralize harmful compounds called free radicals that damage cells at the genetic level.
What makes alpha-lipoic acid so unique is that it is soluble in both water and fat. That means that it can deliver energy immediately or warehouse it for future use.
Alpha-lipoic acid can also recycle “used” antioxidants, including vitamin C, vitamin E, and a potent amino acid compound known as glutathione.1 Whenever these antioxidants neutralize a free radical, they destabilize and become free radicals themselves. Alpha-lipoic acid helps restore them by absorbing excess electrons and converting them to the back to their stable form.
Alpha-lipoic acid is sometimes taken as a supplement under the presumption it can improve certain metabolic functions, including fat burning, collagen production, and blood glucose control. There is growing evidence of at least some of these claims.
Alpha Lipoic Acid (ALA) (1077-28-7) benefits
Diabetes
It has long been presumed that alpha-lipoic acid can aid in the control of glucose by increasing the speed in which the blood sugar is metabolized. This could potentially aid in the treatment of diabetes, a disease characterized by abnormally high blood glucose levels.
A 2018 systematic review and meta-analysis of 20 randomized controlled trials of people with metabolic disorders (some had type 2 diabetes, others had other metabolic disorders) found that lipoic acid supplementation lowered fasting blood glucose, insulin concentration, insulin resistance, and blood hemoglobin A1C levels.
Nerve Pain
Neuropathy is the medical term used to describe the pain, numbness, and abnormal sensations caused by nerve damage. Oftentimes, the damage is caused by the oxidative stress placed on the nerves by chronic diseases such as diabetes, Lyme disease, shingles, thyroid disease, kidney failure, and HIV.
It is believed by some that alpha-lipoic acid, given in large enough doses, can counter this stress by exerting potent antioxidant activity. There has been evidence of this effect in people with diabetic neuropathy, a potentially debilitating condition experienced in people with advanced diabetes.
A 2012 review of studies from the Netherlands concluded that a daily 600-mg intravenous dose of alpha-lipoic acid given over three weeks provided “significant and clinically relevant reduction in neuropathic pain.”
As with the previous diabetes studies, oral alpha-lipoic acid supplements were generally less effective or had no effect at all.
Weight Loss
Alpha-lipoic acid’s ability to enhance calorie burning and promote weight loss has been exaggerated by many diet gurus and supplements manufacturers. With that being said, there is growing evidence that alpha-lipoic acid can influence weight, albeit modestly.
A 2017 review of studies from the Yale University found that alpha-lipoic acid supplements, ranging in dose from 300 to 1,800 mg daily, helped prompt an average weight loss of 2.8 pounds compared to a placebo.
There was no association between the alpha-lipoic supplement dose and the amount of weight loss. Moreover, the duration of treatment appears to influence a person’s body mass index (BMI), but not the person’s actual weight.
What this means is that, while it appears you can only lose so much weight with alpha-lipoic acid, your body composition may improve as fat is gradually replaced by lean muscle.
High Cholesterol
Alpha-lipoic acid has long been believed to influence weight and health by altering the lipid (fat) composition in the blood. This includes increasing “good” high-density lipoprotein (HDL) cholesterol while lowering “bad” low-density lipoprotein (LDL) cholesterol and triglycerides. Recent research suggests this may not be so.
In a 2011 study from Korea, 180 adults provided 1,200 to 1,800 mg of alpha-lipoic acid lost 21 percent more weight than the placebo group after 20 weeks but experienced no improvements in total cholesterol, LDL, HDL, or triglycerides.
In fact, higher doses of alpha-lipoic acid conferred to increases in total cholesterol and LDL in the study participants.
Sun-Damaged Skin
Cosmetics manufacturers often like to boast that their products benefit from the “anti-aging” properties of alpha-lipoic acid. Research suggests that there may some credence to these claims. A review article notes that it is a powerful antioxidant and has been studied for its protective effects against radiation damage.
Alpha Lipoic Acid (ALA) (1077-28-7) uses?
Alpha-lipoic acid or ALA is a naturally occurring compound that’s made in the body. It serves vital functions at the cellular level, such as energy production. As long as you’re healthy, the body can produce all the ALA it needs for these purposes. Despite that fact, there has been a lot of recent interest in using ALA supplements. Advocates of ALA make claims that range from beneficial effects for treating conditions such as diabetes and HIV to enhancing weight loss.
Alpha Lipoic Acid (ALA) (1077-28-7) Dosage
While considered safe, there are no guidelines directing the appropriate use of alpha-lipoic acid. Most oral supplements are sold in formulations ranging from 100 to 600 mg. Based on the bulk of the current evidence, a maximum daily dose of up to 1,800 mg is presumed to be safe in adults.
With that being said, everything from body weight and age to liver function and kidney function can impact what is safe for you as an individual. As a general rule of thumb, err on the side of caution and always opt for a lower dose.
Alpha lipoic acid supplements can be found online and in many health food stores and drugstores. For maximum absorption, the supplements should be taken on an empty stomach.
Alpha-lipoic Acid powder for sale(Where to Buy Alpha-lipoic Acid powder in bulk)
Our company enjoys long term relationships with our clients because we focus on customer service and providing great products. If you are interested in our product, we are flexible with the customization of orders to suit your specific need and our quick lead time on orders guarantees you’ll have great tasting our product on-time. We also focus on value-added services. We are available for service questions and information to support your business.
We are an professional Alpha-lipoic Acid powder supplier for several years, we supply products with competitive price, and our product is of the highest quality and undergoes strict, independent testing to ensure that it is safe for consumption around the world.
References
- Haenen, GRMM; Bast, A (1991). “Scavenging of hypochlorous acid by lipoic acid”. Biochemical Pharmacology. 42 (11): 2244–6. doi:10.1016/0006-2952(91)90363-A. PMID 1659823.
- Biewenga, GP; Haenen, GR; Bast, A (September 1997). “The pharmacology of the antioxidant lipoic acid”. General Pharmacology. 29 (3): 315–31. doi:10.1016/S0306-3623(96)00474-0. PMID 9378235.
- Schupke, H; Hempel, R; Peter, G; Hermann, R; et al. (June 2001). “New metabolic pathways of alpha-lipoic acid”. Drug Metabolism and Disposition. 29 (6): 855–62. PMID 11353754.
- Acker, DS; Wayne, WJ (1957). “Optically active and radioactive α-lipoic acids”. Journal of the American Chemical Society. 79 (24): 6483–6487. doi:10.1021/ja01581a033.
- Hornberger, CS; Heitmiller, RF; Gunsalus, IC; Schnakenberg, GHF; et al. (1952). “Synthetic preparation of lipoic acid”. Journal of the American Chemical Society. 74 (9): 2382. doi:10.1021/ja01129a511.
