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Wnt&Beta catenin

PF670462 (950912-80-8)

PF-670462 hydrochloride, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Not Intended for Therapeutic Use. For research use only.

CAS: 950912-80-8 Category

PF670462 (950912-80-8) Description

PF-670462 is a potent inhibitor of the CK1 isoforms CK1ε and CK1δ (IC50 = 7.7 and 14 nM, respectively). Inhibition of CKIepsilon yields a perturbation of oscillator function that forestalls light as a zeitgeber, and they demonstrate that pharmacological tools such as PF-670462 may yield valuable insight into clock function. Casein kinase Iepsilon (CKIepsilon) is an essential component of the biological clock, phosphorylating PER proteins, and in doing so regulating their turnover and nuclear entry in oscillator cells of the suprachiasmatic nucleus (SCN).

PF670462 (950912-80-8) Specifications

Product Name PF-670462 HCl
Synonym PF-670462; PF 670462; PF670462; PF-670462 HCl; PF-670462 hydrochloride.
Chemical Name 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine dihydrochloride
Drug Class N/A
Purity ≥ >98%
CAS Number 950912-80-8
Molecular Formula C19H22Cl2FN5
Molecular Weight 410.3184
Monoisotopic Mass 337.1703
MDL number SML0795
InChIKey PSNKGVAXBSAHCH-UHFFFAOYSA-N
InChi Code  InChI=1S/C19H20FN5.2ClH/c20-14-8-6-13(7-9-14)17-18(16-10-11-22-19(21)24-16)25(12-23-17)15-4-2-1-3-5-15;;/h6-12,15H,1-5H2,(H2,21,22,24);2*1H
SMILES NC1=NC=CC(C2=C(C3=CC=C(F)C=C3)N=CN2C4CCCCC4)=N1.[H]Cl.[H]Cl
Form  PF670462
Color white to beige
Solubility  Soluble in DMSO
Storage Temp.  0 – 4 C for short term (days to weeks), or -20 C for long term (months).
Shelf life > >2 years if stored properly
Handling N/A
Application N/A

 


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RIDADR NONH for all modes of transport

References:

[1]. Keenan CR, Langenbach SY, Jativa F, Harris T, Li M, Chen Q, Xia Y, Gao B, Schuliga MJ, Jaffar J, Prodanovic D, Tu Y, Berhan A, Lee PVS, Westall GP, Stewart AG. Front Pharmacol. 2018 Jul 10;9:738. doi: 10.3389/fphar.2018.00738. eCollection 2018.

[2]. Hiramoto K, Yamate Y, Kasahara E, Sato EF. Int J Biol Sci. 2018 Jun 2;14(9):992-999. doi: 10.7150/ijbs.24558. eCollection 2018.

[3]. Janovska P, Verner J, Kohoutek J, Bryjova L, Gregorova M, Dzimkova M, Skabrahova H, Radaszkiewicz T, Ovesna P, Vondalova Blanarova O, Nemcova T, Hoferova Z, Vasickova K, Smyckova L, Egle A, Pavlova S, Poppova L, Plevova K, Pospisilova S, Bryja V. Blood. 2018 Mar 15;131(11):1206-1218. doi: 10.1182/blood-2017-05-786947. Epub 2018 Jan 9.

[4].Wager TT, Galatsis P, Chandrasekaran RY, Butler TW, Li J, Zhang L, Mente S, Subramanyam C, Liu S, Doran AC, Chang C, Fisher K, Grimwood S, Hedde JR, Marconi M, Schildknegt K. ACS Chem Neurosci. 2017 Sep 20;8(9):1995-2004. doi: 10.1021/acschemneuro.7b00155. Epub 2017 Jun 30.

[5]. Patton AP, Chesham JE, Hastings MH. J Neurosci. 2016 Sep 7;36(36):9326-41. doi: 10.1523/JNEUROSCI.0958-16.2016.

1 review for PF670462 (950912-80-8)

  1. Rated 5 out of 5

    Cofttek

    Never had such good experience before,The PF670462 (950912-80-8) is high purity,also customer service is pretty nice !gotta try!!

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