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Akt &GSK-3

SC66 (871361-88-5)

SC66 is a novel AKT inhibitor, IC50 values of approximately 0.75 μg/ml at 72 hours in HepG2, HA22T/VGH and PLC/PRF/5 cells…

Not Intended for Therapeutic Use. For research use only.

CAS: 871361-88-5 Category

SC66 (871361-88-5) Description:

SC66 is a novel and potent AKT inhibitor, which reduced cell viability in a dose- and time-dependent manner, inhibited colony formation and induced apoptosis in HCC cells. SC66 treatment led to a reduction in total and phospho-AKT levels. SC66 significantly potentiated the effects of both conventional chemotherapeutic and targeted agents, doxorubicin and everolimus, respectively. In vivo, SC66 inhibited tumor growth of Hep3B cells in xenograft models, with a similar mechanism observed in the in vitro model. SC66 had antitumor effects on HCC cells.

SC66 (871361-88-5) Specifications:

Product Name SC66
Synonym SC66; SC66; SC 66.
Chemical Name (2E,6E)-2,6-bis(pyridin-4-ylmethylene)cyclohexanone
Drug Class Antineoplastics
Purity ≥98% (HPLC)
CAS Number 871361-88-5
Molecular Formula C18H16N2O
Molecular Weight 276.33
Monoisotopic Mass 276.12626 g/mol
MDL number MFCD05025493
InChIKey CYVVJSKZRBZHAV-UNZYHPAISA-N
InChi Code InChI=1S/C18H16N2O/c21-18-16(12-14-4-8-19-9-5-14)2-1-3-17(18)13-15-6-10-20-11-7-15/h4-13H,1-3H2/b16-12+,17-13+
SMILES O=C1/C(CCC/C1=C\C2=CC=NC=C2)=C/C3=CC=NC=C3
Form Powder
Color faintly yellow to dark yellow
Solubility  Soluble in DMSO, not soluble in water
Storage Temp.  0 – 4 C for short term (days to weeks), or -20 C for long term (months)
Shelf life >2 years if stored properly
Handling Protect from air and moisture
Application SC66 is a novel and potent AKT inhibitor

 


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RIDADR NONH for all modes of transport

References:

[1]. Cusimano A, Puleio R, D’Alessandro N, Loria GR, McCubrey JA, Montalto G, Cervello M. Cytotoxic activity of the novel small molecule AKT inhibitor SC66 in hepatocellular carcinoma cells. Oncotarget. 2015 Jan 30;6(3):1707-22. PubMed PMID: 25596737.

[2]. Tran HT, Zhang S. Accurate prediction of the bound form of the Akt pleckstrin homology domain using normal mode analysis to explore structural flexibility. J Chem Inf Model. 2011 Sep 26;51(9):2352-60. doi: 10.1021/ci2001742. Epub 2011 Aug 25. PubMed PMID: 21834588; PubMed Central PMCID: PMC3807676.

[3]. Jo H, Lo PK, Li Y, Loison F, Green S, Wang J, Silberstein LE, Ye K, Chen H, Luo HR. Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination. Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6486-91. doi: 10.1073/pnas.1019062108. Epub 2011 Apr 4. PubMed PMID: 21464312; PubMed Central PMCID: PMC3081014.

[4]. Cytotoxic activity of the novel small molecule AKT inhibitor SC66 in hepatocellular carcinoma cells. Cusimano A, Puleio R, D’Alessandro N, Loria GR, McCubrey JA, Montalto G, Cervello M. Oncotarget. 2015 Jan 30;6(3):1707-22. PMID: 25596737.

[5].Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination. Jo H, Lo PK, Li Y, Loison F, Green S, Wang J, Silberstein LE, Ye K, Chen H, Luo HR. Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6486-91. doi: 10.1073/pnas.1019062108. Epub 2011 Apr 4. PMID: 21464312.

1 review for SC66 (871361-88-5)

  1. Cofttek

    Never had such good experience before,The SC66 (871361-88-5) is high purity,also customer service is pretty nice !gotta try!!

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