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GPCR&G protein

NSC23766 (733767-34-5)

NSC 23766 is an inhibitor of Rac GTPase targeting Rac activation by guanine nucleotide exchange factors (GEFs) with IC50 of ~50 μM in a cell-free assay; does not inhibit the closely related targets, Cdc42 or RhoA.

Not Intended for Therapeutic Use. For research use only.

CAS: 733767-34-5 Category

NSC23766 (733767-34-5) Description

NSC23766 is a potent Rac1 inhibitor. NSC23766 disrupted polar secretion of adhesive, polarization of endomembranes, and tip-focused growth in the rhizoid. NSC23766 can acts as a competitive antagonist at muscarinic acetylcholine receptors. NSC23766 exerts anti-influenza virus properties by affecting the viral polymerase complex activity. NSC23766 suppresses CREB signaling by targeting NMDA receptor function.

NSC23766 (733767-34-5) Specifications

Product Name NSC23766
Synonyms   NSC23766; NSC23766; NSC 23766.
Chemical Names  Nsc 23766; 733767-34-5; NSC-23766; NSC23766; N6-(2-((5-(diethylamino)pentan-2-yl)amino)-6-methylpyrimidin-4-yl)-2-methylquinoline-4,6-diamine; N6-[2-[[4-(diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-4,6-quinolinediamine
Purity >98%
CAS Number  733767-34-5
Molecular Formula C24H35N7
Molecular Weight 421.593 g/mol
Monoisotopic Mass 421.295 g/mol
InChIKey DEFBCZWQLILOJF-UHFFFAOYSA-N
InChi Code InChI=1S/C24H35N7/c1-6-31(7-2)12-8-9-16(3)27-24-28-18(5)14-23(30-24)29-19-10-11-22-20(15-19)21(25)13-17(4)26-22/h10-11,13-16H,6-9,12H2,1-5H3,(H2,25,26)(H2,27,28,29,30)
SMILES CCN(CC)CCCC(C)NC1=NC(=CC(=N1)NC2=CC3=C(C=C2)N=C(C=C3N)C)C
Form Powder
Color N/A
Solubility  may be formulated in DMSO
Storage Temp.  −20°C
Shelf life >2 years if stored properly.
Handling Dry, dark
Application  a potent Rac1 inhibitor

 


=

RIDADR NONH for all modes of transport

References:

  • 1: Hou H, Chávez AE, Wang CC, Yang H, Gu H, Siddoway BA, Hall BJ, Castillo PE, Xia H. The Rac1 inhibitor NSC23766 suppresses CREB signaling by targeting NMDA receptor function. J Neurosci. 2014 Oct 15;34(42):14006-12. doi: 10.1523/JNEUROSCI.1659-14.2014. PubMed PMID: 25319697; PubMed Central PMCID: PMC4198541.
  • 2: Zhu S, Chen P, Wu Y, Xiong S, Sun H, Xia Q, Shi L, Liu H, Ouyang HW. Programmed Application of Transforming Growth Factor β3 and Rac1 Inhibitor NSC23766 Committed Hyaline Cartilage Differentiation of Adipose-Derived Stem Cells for Osteochondral Defect Repair. Stem Cells Transl Med. 2014 Oct;3(10):1242-51. doi: 10.5966/sctm.2014-0042. Epub 2014 Aug 25. PubMed PMID: 25154784; PubMed Central PMCID: PMC4181399.
  • 3: Liao J, Ye Z, Huang G, Xu C, Guo Q, Wang E. Delayed treatment with NSC23766 in streptozotocin-induced diabetic rats ameliorates post-ischemic neuronal apoptosis through suppression of mitochondrial p53 translocation. Neuropharmacology. 2014 Oct;85:508-16. doi: 10.1016/j.neuropharm.2014.06.008. Epub 2014 Jun 20. PubMed PMID: 24953831.
  • 4: Dierkes R, Warnking K, Liedmann S, Seyer R, Ludwig S, Ehrhardt C. The Rac1 inhibitor NSC23766 exerts anti-influenza virus properties by affecting the viral polymerase complex activity. PLoS One. 2014 Feb 11;9(2):e88520. doi: 10.1371/journal.pone.0088520. eCollection 2014. PubMed PMID: 24523909; PubMed Central PMCID: PMC3921225.
  • 5: Zhu S, Lu P, Liu H, Chen P, Wu Y, Wang Y, Sun H, Zhang X, Xia Q, Heng BC, Zhou Y, Ouyang HW. Inhibition of Rac1 activity by controlled release of NSC23766 from chitosan microspheres effectively ameliorates osteoarthritis development in vivo. Ann Rheum Dis. 2015 Jan;74(1):285-93. doi: 10.1136/annrheumdis-2013-203901. Epub 2013 Nov 20. PubMed PMID: 24257023.
  • 6: Levay M, Krobert KA, Wittig K, Voigt N, Bermudez M, Wolber G, Dobrev D, Levy FO, Wieland T. NSC23766, a widely used inhibitor of Rac1 activation, additionally acts as a competitive antagonist at muscarinic acetylcholine receptors. J Pharmacol Exp Ther. 2013 Oct;347(1):69-79. doi: 10.1124/jpet.113.207266. Epub 2013 Jul 25. PubMed PMID: 23887096

1 review for NSC23766 (733767-34-5)

  1. Rated 5 out of 5

    Cofttek

    Never had such good experience before,The NSC23766 (733767-34-5) is high purity,also customer service is pretty nice !gotta try!!

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