AC480 (BMS-599626) (714971-09-2) Description:
AC480, also known as BMS-599626 is an orally bioavailable inhibitor of the HER1, HER2 and HER4 tyrosine kinases (IC50 =22, 32 and 190 nM, respectively) with potential antineoplastic activity. BMS-599626 inhibits human epidermal growth factor receptors (HER) HER1, HER2 and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors.
AC480 (BMS-599626) (714971-09-2) Specifications:
Product Name | AC480 (BMS-599626) |
Chemical Name | BMS-599626; 714971-09-2; AC480; AC-480; BMS 599626; (S)-Morpholin-3-ylmethyl (4-((1-(3-fluorobenzyl)-1H-indazol-5-yl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)carbamate |
Purity | >98% (HPLC) |
CAS Number | 714971-09-2 |
Molecular Formula | C27H27FN8O3 |
Molecular Weight | 530.564 g/mol |
Monoisotopic Mass | 530.219 g/mol |
InChIKey | LUJZZYWHBDHDQX-QFIPXVFZSA-N |
InChi Code | InChI=1S/C27H27FN8O3/c1-17-23(34-27(37)39-15-22-14-38-8-7-29-22)13-36-25(17)26(30-16-32-36)33-21-5-6-24-19(10-21)11-31-35(24)12-18-3-2-4-20(28)9-18/h2-6,9-11,13,16,22,29H,7-8,12,14-15H2,1H3,(H,34,37)(H,30,32,33)/t22-/m0/s1 |
SMILES | O=C(OC[[email protected]]1NCCOC1)NC2=CN3N=CN=C(NC4=CC5=C(N(CC6=CC=CC(F)=C6)N=C5)C=C4)C3=C2C |
Form | Powder |
Color | N/A |
Solubility | Soluble in DMSO |
Storage Temp. | -20°C |
Shelf life | >2 years if stored properly |
Handling | Protect from air and moisture |
Application | an orally bioavailable inhibitor |