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S6 kinase&PKD-1

MLS-2052 (BIO) (667463-62-9)

BIO(6-bromoindirubin-3′-oxime) is a specific inhibitor of GSK-3 with IC50 of 5 nM for GSK-3α/β, shows >16-fold selectivity over CDK5, also a pan-JAK inhibitor…

Not Intended for Therapeutic Use. For research use only.

CAS: 667463-62-9 Category

MLS-2052 (BIO) (667463-62-9) Description:

MLS-2052, aso known as BIO and GSK3 Inhibitor IX, is a cell-permeable bis-indolo (indirubin) compound that acts as a highly potent, selective, reversible, and ATP-competitive inhibitor of GSK3α/β (IC50 = 5 nM).

MLS-2052 (BIO) (667463-62-9) Specifications:

Product Name MLS-2052(BIO)
Synonym BIO; GSK3 Inhibitor IX; MLS 2052; MLS-2052; MLS2052.
Chemical Name 6-Bromoindirubin-3′-oxime
Drug Class Antineoplastics
Purity ≥98% (HPLC)
CAS Number 667463-62-9
Molecular Formula C16H10BrN3O2
Molecular Weight 356.179
Monoisotopic Mass 354.9956 g/mol
MDL number MFCD08705318
InChIKey DDLZLOKCJHBUHD-WAVHTBQISA-N
InChi Code InChI=1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,18,22H,(H,19,21)/b15-13-,20-14+
SMILES O=C(/C1=C2NC3=C(C\2=N/O)C=CC=C3)NC4=C1C=CC(Br)=C4
Form Powder
Color dark red
Solubility  Soluble in DMSO, not soluble in water
Storage Temp.  0 – 4 C for short term (days to weeks), or -20 C for long term (months)
Shelf life >2 years if stored properly
Handling Protect from air and moisture
Application MLS-2052, aso known as BIO and GSK3 Inhibitor IX

 


RIDADR NONH for all modes of transport

References:

[1]. Meijer, L., Skaltsounis, A.L., Magiatis, P., et al. GSK-3-selective inhibitors derived from tyrian purple indirubins. Chem. Biol. 10(12), 1255-1266 (2003).

[2]. Polychronopoulos, P., Magiatis, P., Skaltsounis, A.L., et al. Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. J. Med. Chem. 47(4), 935-946 (2004).

[3]. Sato, N., Meijer, L., Skaltsounis, L., et al. Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nature Medicine 10(1), 55-63 (2004).

[4]. Tseng, A.S., Engel, F.B., and Keating, M.T. The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes. Chemistry & Biology 13, 957-963 (2006).

[5].Phosphatase PP2A and microtubule-mediated pulling forces disassemble centrosomes during mitotic exit. Enos SJ, Dressler M, Gomes BF, Hyman AA, Woodruff JB. Biol Open. 2018 Jan 12;7(1). pii: bio029777. doi: 10.1242/bio.029777. PMID: 29222174.