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Akt &GSK-3

TWS119 (601514-19-6)

TWS119 is a GSK-3β inhibitor with IC50 of 30 nM; capable of inducing neuronal differentiation and may be useful to stem cell biology.

Not Intended for Therapeutic Use. For research use only.

CAS: 601514-19-6 Category

TWS119 (601514-19-6) Description:

TWS-119 is a potent and selective inhibitor of glycogen synthase kinase-3β (IC50 = 30 nM). TWS119 could activate Wnt/β-catenin pathway and up-regulate the expression of CD62L in a dose-dependent manner, but it decreased the expression of CD107a. Glycogen synthase kinase (GSK)-3, a constitutively active serine-threonine kinase, acts as a key regulator of major signaling pathways, including the Wnt, Hedgehog, and Notch pathways.

TWS119 (601514-19-6) Specifications:

Product Name TWS119
Synonym TWS-119; TWS119; TWS 119.
Chemical Name 3-((6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenol
Drug Class Antineoplastics
Purity ≥98% (HPLC)
CAS Number 601514-19-6
Molecular Formula C18H14N4O2
Molecular Weight 318.34
Monoisotopic Mass 318.11168 g/mol
MDL number MFCD09037535
InChi Code InChI=1S/C18H14N4O2/c19-12-4-1-3-11(7-12)16-9-15-17(22-16)20-10-21-18(15)24-14-6-2-5-13(23)8-14/h1-10,23H,19H2,(H,20,21,22)
Form Powder
Color White
Solubility  Soluble in DMSO, not soluble in water
Storage Temp.  0 – 4 C for short term (days to weeks), or -20 C for long term (months)
Shelf life >2 years if stored properly
Handling Protect from air and moisture
Application TWS-119 is a potent and selective inhibitor



RIDADR NONH for all modes of transport


[1]. Jiang H, Xiao J, Kang B, Zhu X, Xin N, Wang Z. PI3K/SGK1/GSK3β signaling pathway Is involved in inhibition of autophagy in neonatal rat cardiomyocytes exposed to hypoxia/reoxygenation by Hydrogen sulfide. Exp Cell Res. 2015 Jul 8. pii: S0014-4827(15)30035-5. doi: 10.1016/j.yexcr.2015.07.005. [Epub ahead of print] PubMed PMID: 26163895.

[2]. Zhou YX, Shi Z, Singh P, Yin H, Yu YN, Li L, Walsh MP, Gui Y, Zheng XL. Potential Role of Glycogen Synthase Kinase-3β in Regulation of Myocardin Activity in Human Vascular Smooth Muscle Cells. J Cell Physiol. 2015 Jun 30. doi: 10.1002/jcp.25084. [Epub ahead of print] PubMed PMID: 26129946.

[3]. Li YS, Xi Y, Li XJ, Leng CL, Jia MM, Zhang WK, Tang HB. Up-Regulation of the Biosynthesis and Release of Substance P through Wnt/β-Catenin Signaling Pathway in Rat Dorsal Root Ganglion Cells. PLoS One. 2015 Jun 8;10(6):e0129701. doi: 10.1371/journal.pone.0129701. eCollection 2015. PubMed PMID: 26054011; PubMed Central PMCID: PMC4459973.

[4]. Cheng PW, Chen YY, Cheng WH, Lu PJ, Chen HH, Chen BR, Yeh TC, Sun GC, Hsiao M, Tseng CJ. Wnt Signaling Regulates Blood Pressure by Downregulating a GSK-3β-Mediated Pathway to Enhance Insulin Signaling in the Central Nervous System. Diabetes. 2015 Apr 16. pii: db141439. [Epub ahead of print] PubMed PMID: 25883115.

[5].Chen Y, Zheng L, Liu J, Zhou Z, Lv X, Zhang J, Zhang S, Sun L, Chen F. [Activation of Wnt/β-catenin pathway in NK cells by glycogen synthase kinase-3β inhibitor TWS119 promotes the expression of CD62L]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2015 Jan;31(1):44-8. Chinese. PubMed PMID: 25575058.