Specifications
| Name: | Gamma-aminobutyric acid(GABA) |
| CAS: | 56-12-2 |
| Purity | 98% |
| Molecular Formula: | C4H9NO2 |
| Molecular Weight: | 103.120 g/mol |
| Melt Point: | 203.7 °C |
| Chemical name: | 4-aminobutanoic acid |
| Synonyms: | 4-Aminobutanoic acid
gamma-aminobutyric acid GABA |
| InChI Key: | BTCSSZJGUNDROE-UHFFFAOYSA-N |
| Half Life: | N/A |
| Solubility: | Soluble in water(130 g/100 mL) |
| Storage Condition: | 0 – 4 C for short term (days to weeks), or -20 C for long term (months) |
| Application: | GABA is considered an inhibitory neurotransmitter because it blocks, or inhibits, certain brain signals and decreases activity in your nervous system. |
| Appearance: | white microcrystalline powder |
Gamma-aminobutyric acid(GABA) (56-12-2) NMR Spectrum
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What is Gamma-aminobutyric acid?
Gamma aminobutyric acid (GABA) is a naturally occurring amino acid that works as a neurotransmitter in your brain. Neurotransmitters function as chemical messengers. GABA is considered an inhibitory neurotransmitter because it blocks, or inhibits, certain brain signals and decreases activity in your nervous system.
Gamma-aminobutyric acid (GABA) powder is an endogenous neurotransmitter that controls neuronal excitability, muscle tone, stem cell growth, brain development, and mood. During development, GABA acts as an excitatory neurotransmitter but switches later to an inhibitory function. GABA displays anxiolytic, anticonvulsant, and amnestic activities, inducing relaxation and decreasing anxiety in clinical settings. Its principal role is reducing neuronal excitability throughout the nervous system. GABA is sold as a dietary supplement.
GABA(56-12-2) benefits
GABA for sleep
“GABA enables the body and mind to relax and fall asleep and sleep soundly throughout the night,” says Michael J. Breus, Ph.D., clinical psychologist and board-certified sleep specialist. GABA-A receptors are also highly expressed in the thalamus, a brain region involved in sleep processes, and in one study, patients with insomnia had GABA levels nearly 30% lower than people without the sleep disorder.
In a recent study, participants who took 100 mg of a natural form of GABA (PharmaGABA) before bed fell asleep faster and had better quality sleep after one week of supplementation.
“When your body produces [GABA], your central nervous system slows down, which makes a person feel more relaxed, and in many cases sleepy. In fact, most of the current sleep aids support normal GABA levels in the brain,” says Breus.
Additionally, supplementation with magnesium, which is a GABA agonist (i.e., a substance that binds to GABA receptors and activates them the same as GABA would, explains Ruhoy), has been shown to support sleep quality.
GABA for stress and anxious thoughts
Given GABA’s role in balancing out the excitatory effects of glutamine, it’s thought that it also helps to keep feelings of stress in check (this is why many anti-anxiety drugs target GABA-A receptors). Several studies illustrate how adequate GABA levels can trigger calming effects.
In one small study, researchers had participants consume either distilled water, distilled water with L-theanine (a calming compound in green tea), or distilled water with a natural form of GABA (PharmaGABA). Sixty minutes later, they measured their brain waves with an electroencephalogram (EEG) test and found that GABA significantly increased participants’ alpha brainwaves (which are typically generated in a relaxed state) and decreased beta brainwaves (typically seen in stressful situations) compared to L-theanine or water.
In another experiment conducted by the same researchers, participants with a fear of heights received either a placebo or 200 mg GABA (in the form of PharmaGABA) before walking across a suspension bridge over a canyon. Salivary levels of the antibody immunoglobulin-A (sIgA)—which is associated with relaxation at higher levels—were measured at various stages. The placebo group experienced a significant drop in sIgA, while the GABA group’s levels remained stable and even increased slightly by the end, indicating that they remained more relaxed.
GABA and mental focus
Research demonstrates that GABA can have a positive influence on an individual’s ability to perform mental tasks that require significant concentration and relieve both the psychological and physical fatigue that typically impair this concentration.
In one small study, participants (several of whom had chronic fatigue) were given a beverage containing either 0, 25, or 50 mg of GABA and then asked to perform a difficult math problem. Researchers found that those in the two GABA groups experienced a significant reduction in psychological and physical fatigue, as measured by reductions in certain biomarkers including cortisol.* Those in the 50-mg group also scored higher on the math problem, suggesting improved focus and problem-solving ability.
GABA for healthy blood pressure
Preliminary research suggests GABA can promote healthy blood pressure, at least according to a few lab studies. It is hypothesized that GABA might be acting by helping blood vessels to better dilate, thus promoting healthy blood pressure.
Understanding just how effective GABA might be for supporting healthy blood pressure will require more robust research, but one early study found that daily supplementation with 80 mg of GABA had a positive effect on blood pressure in adults.
Gamma-aminobutyric acid uses?
Gamma-aminobutyric acid—often referred to as GABA—is an amino acid and neurotransmitter, a type of chemical responsible for carrying information from one cell to another.
Produced naturally in the body, GABA is also widely available in supplement form. Manufacturers claim that GABA supplements can help boost the brain’s GABA levels and treat anxiety, stress, depression, and sleep problems. In fact, some supplement manufacturers call GABA a “natural form of Valium”—presumably meaning that it reduces stress and improves relaxation and sleep.
Research shows that GABA might play a key role in protecting against depression and anxiety. For instance, a study published in the Journal of Biological Chemistry in 2010 indicates that people with major depression may be more likely to have low levels of GABA.2 And a 2009 study that increasing GABA levels may be useful in the treatment of conditioned fear. These results are consistent with the fact that GABA is the primary calming (inhibitory) neurotransmitter in the brain.
dosage
GABA is taken by mouth for relieving anxiety, improving mood, reducing symptoms of premenstrual syndrome (PMS), and treating attention deficit-hyperactivity disorder (ADHD). It is also used for promoting lean muscle growth, burning fat, stabilizing blood pressure, and relieving pain.
Because there is limited information about GABA supplements, there is no recommended dose if you choose to supplement.
In clinical trials, various doses of GABA supplements have been used. For example, 100 mL of fermented milk containing 10-12 mg of GABA per 100 mL was used by patients with high blood press in a study where they consumed the drink daily at breakfast for 12 weeks. In another study, a chlorella supplement containing 20 mg of GABA was taken twice daily for 12 weeks.
GABA powder for sale(Where to Buy GABA powder in bulk)
Our company enjoys long term relationships with our clients because we focus on customer service and providing great products. If you are interested in our product, we are flexible with the customization of orders to suit your specific need and our quick lead time on orders guarantees you’ll have great tasting our product on-time. We also focus on value-added services. We are available for service questions and information to support your business.
We are an professional GABA powder supplier for several years, we supply products with competitive price, and our product is of the highest quality and undergoes strict, independent testing to ensure that it is safe for consumption around the world.
References
[1] Haynes, William M., ed. (2016). CRC Handbook of Chemistry and Physics (97th ed.). CRC Press. pp. 5–88. ISBN 978-1498754286.
[2] W. G. Van der Kloot; J. Robbins (1959). “The effects of GABA and picrotoxin on the junctional potential and the contraction of crayfish muscle”. Experientia. 15: 36.
[3] Roth RJ, Cooper JR, Bloom FE (2003). The Biochemical Basis of Neuropharmacology. Oxford [Oxfordshire]: Oxford University Press. p. 106. ISBN 978-0-19-514008-8.
