Palmitoylethanolamide powder video
Palmitoylethanolamide (PEA) powder Specifications
|Purity||98% Micronized PEA；98% powder|
|Molecular Weight:||299.49 g/mol|
|Melt Point:||93 to 98 °C|
|Chemical name:||Hydroxyethylpalmitamide Palmidrol N-Palmitoylethanolamine Palmitylethanolamide|
|Half Life:||8 hours|
|Solubility:||Soluble in DMSO, Methanol, Water|
|Storage Condition:||0 – 4 C for short term (days to weeks), or -20 C for long term (months)|
|Application:||Palmitoylethanolamide (PEA) belong to endocannabinoid family, a group of fatty acid amides. PEA has been proven to have analgesic and anti-inflammatory activity and has been used in several controlled studies focused on the management of chronic pain among adult patients with different underlying clinical conditions.|
Palmitoylethanolamide (544-31-0) NMR Spectrum
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Palmitoylethanolamide is an endogenic fatty acid amide that falls under the class of Nuclear Factor Agonists. It naturally occurs in foods such as soybean, lecithin peanuts, and the human body.
Palmitoylethanolamide was first discovered in the early 1940s. Scientists first found that consumption of powdered egg yolk promoted a healthy immune response in children and decreased the risk of developing rheumatic fever. Further research concluded that egg yolks contained a special compound i.e., PEA. PEA has also been found in whole foods like peanuts and soybean, which help provide strong immunity and health benefits.
Besides being found in certain foods, PEA is also occurring in our body naturally. The chemical is produced in our body by many of our cells as a part of a healthy immune response. PEA is specially made by our body in response to inflammation. It is known to manage our pain in the body by protecting our immune system from overreacting and it promotes a healthy immune and inflammatory reaction in the body.
Palmitoylethanolamide powder is mostly used as a medicine for pain, fibromyalgia, neuropathic pain, multiple sclerosis, carpal tunnel syndrome, and many other conditions.
Palmitoylethanolamide and the Cannabinoid Family
Palmitoylethanolamide does not necessarily come from cannabis but can be considered part of the cannabinoid family. PEA works in a very similar way to CBD (cannabidiol), which is one of the main compounds in cannabis but it doesn’t have psychogenic effects. CBD products are very popular these days and are available in almost everything from oils to creams, and food products. CBD products are also used for many potential health benefits, including mental, nerve, and joint health.
PEA is also a cannabinoid, but it is analyzed as an endocannabinoid as it is made within the body. However, it is different from cannabidiol and tetrahydrocannabinol as the body does not naturally make these chemicals.
Mechanism of Action
Palmitoylethanolamide triggers the fat-burning, energy-boosting, and anti-inflammatory PPAR alpha. When these key proteins get activated, PEA stops the action of genes capable of promoting inflammation and reduces the production of several inflammatory substances. PEA also minimizes the activity of the gene FAAH that breaks down natural cannabinoid anandamide and maximizes the levels of anandamide in the body. Anandamide is responsible for decreasing your pain, calming your mind, and promoting relaxation in your body.
PEA is also known to bind to the body cells and reduce pain and swelling. It contains palmitic acid in its structure, which helps the body make Palmitoylethanolamide in the body.
According to some scientists, simply increasing your intake of palmitic acid will not affect PEA production. This is because your body will only utilize PEA in your body only when it needs to heal your inflammation or pain. This results in the levels of PEA in the body normally varying throughout the day.
The best way to get the benefits of PEA is by consuming PEA-rich foods or standardized supplements.
Palmitoylethanolamide powder benefits and applications
PEA has been proven to have pain-relieving and anti-inflammatory properties and has been used for the management of chronic pain among adults with multiple underlying clinical conditions. For example, it can provide a helpful effect like adjuvant for the treatment of low back pain in older patients or can be used alone for chronic pain management in critically ill patients in place of traditional analgesics which have a high risk of adverse effects.
Promising results have been demonstrated in the treatment of non-surgical radiculopathies with an ultra-micronized formulation of PEA and the combination therapy with alpha-lipoic acid to reduce chronic prostatitis/chronic pelvic pain syndrome.
Below are some great benefits of PEA:
· Pain Relief
There is some evidence that validates PEA’s ability to reduce severe pain. PEA has been investigated in over 6 thousand people and 30 clinical trials since the 1070s. However, the study often has failed to differentiate between neuropathic and non-neuropathic pain. The advantages of Palmitoylethanolamide for neuropathic pain are less clear due to less sufficient information to date.
Another restriction was that most of these studies lacked a placebo control and high-quality research is required to decide the effectiveness of PEA in relieving different types of pain.
In a survey of 12 human studies, PEA supplements showed effectiveness in the reduction of chronic and neuropathic pain potency without any serious side effects. Those 12 persons were typically given PEA supplements with dosages between 200 to 1200 mg/day for over 3 to 8 weeks. The supplement took about two weeks to achieve the pain-relieving state. Taking it for any longer period nourished its effects without causing any adverse effects.
Another study performed with 300 or 600 mg/day of PEA showed a strong reduction in sciatica pain in a pivotal trial of over 600 people. PEA reduced pain by over 50% in just 3 weeks, which is hardly achieved with most painkillers.
· Brain health and regeneration
PEA has also been known to be beneficial for neurodegenerative diseases and stroke. The supplement is perceived to improve brain function by helping brain cells to survive and lower inflammation.
In a study of 250 stroke patients, a formulation of PEA with luteolin showed signs of improved recovery. It is also proclaimed to have a beneficial effect on good brain health, cognitive skills, and daily brain functioning. The effects were noticeable after 30 days of supplementation and when after two months of supplementation, more improvement was noticed.
Both with luteolin and alone, PEA was seen to prevent Parkinson’s disease in mice when used with luteolin. It reduces the damage in the brain by protecting the dopamine neurons. However, standard clinical studies are needed to verify these findings.
Another study showed that PEA with luteolin helped to enhance the neurotrophic factors like BDNF & NGF which are small powerful proteins useful to create new brain cells. It enhanced the brain’s ability to regenerate new cells and tissues after distressing damage to the spinal cord or brain. When PEA along with luteolin was used in mice it enhanced the healing of nerves in mice with spinal cord injuries.
Due to the natural occurrence of cannabinoids in PEA, the effects showed an enhancement in patients’ behavior, mood. It showed a decreased seizure risk in mice. However, its effects on seizures are yet to be investigated in humans and further studies are needed to verify this.
· Effects on the Heart
A heart attack occurs as a result of blockage of blood vessels directing to the heart. PEA is known to recover damage of heart tissues and increase the blood flow to the heart which helps minimize the cases of a heart attack. A study in mice also showed the lowering of inflammatory cytokine levels in hearts.
The use of PEA also diminished the level of high blood pressure in rats and prevented kidney damage by reducing inflammatory substances. By narrowing the blood vessels, PEA was effective to block the enzymes and receptors that increase blood pressure.
· Signs of depression
In a recent study, 58 people suffering from depression were treated with PEA. Doses of 1.2 gm per day were given to the patients for over 6 weeks. This resulted in rapid improvement of mood and overall symptoms. PEA when added to antidepressant remedy i.e., citalopram, lowered symptoms of depression by a standard 50%.
· Symptoms of the common cold
Another study showed PEA to be an effective remedy to fight the influenza virus that causes the common cold. In some early surveys of over 4 thousand people, PEA was able to manifest a positive impact in immunity and helped reduce flu-like symptoms in patients.
In another study, 900 young soldiers were given about 1,200 mg of PEA that lessened the duration of the cold and healed symptoms like sore throat, runny nose, fever, and headaches.
· Gut inflammation
Last but not least PEA was successfully used to revive signs of inflammatory bowel disease (IBS) in animals. PEA supplements when tested in mice with chronic gut inflammation, helped normalize the bowel movement and effectively prevented damage to the gut lining.
The gut damage or inflammation is caused by ulcerative colitis which can lead to the risk of cancer. The use of PEA stopped the normal gut tissue from promoting cancerous overgrowth in mice. PEA reduces the inflammatory cytokines and the growth of neutrophils and immune cells that intensifies the symptoms of gut damage.
Palmitoylethanolamide food sources
Although PEA is a saturated fatty acid, including more saturated fats in your diet will do more harm than good. Consuming foods high in saturated fats won’t increase your body’s PEA production instead will increase your risk of developing various chronic and inflammatory diseases.
Foods like soy products, soy lecithin, peanuts, and alfalfa are some great sources of PEA. People with nut allergies should necessarily skip peanuts and consume other foods. Egg yolk is another good source and can be consumed by people who don’t have sensitivity to eggs. Consumers can also consider taking PEA supplements as they are a safer and an effective choice.
PEA supplements dosage & safety
According to clinical studies, at least 600 mg/day may be required to relieve nerve pain, and doses of 1.2 g/day might be used to treat diabetic nerve pain.
For diabetic patients suffering from eye problems, doses up to 1.8 g/day were effective for reducing damage to the eye nerves.
For the cure of the common cold, 1.2 g/day of PEA was the standard dosage.
Talk to your doctor before taking supplements of PEA as PEA has not been approved by the FDA to take in larger doses.
Consuming Palmitoylethanolamide powder or supplements in small, limited doses is generally considered safe. However, more advanced clinical studies are required for higher doses. Long-term PEA supplementation is also known to be safe according to some small-scale studies.
Certain manufacturers from the PEA manufacturer factory recommend splitting the total dose into two portions and consuming it during the day. In some cases, micronized PEA, which in simple words is fine palmitoylethanolamide powder, is known to be better absorbed in the body and scientists consider the powder form to be superior to other forms.
PEA side effects
Oral consumption of palmitoylethanolamide is generally considered safe for most adults when used for up to 3 months. To date, no serious complications or drug-to-drug interaction has been identified. However, there is not enough information to say the drug can be safe when used for longer than three months. Side effects can include an upset stomach, which is very rare.
To be clearer, PEA didn’t cause any serious complications in any of the above studies but it still lacks proper safety studies. Also, there is insufficient evidence to figure the amount of effectiveness of PEA in patients with these types of pain.
Pregnancy and children
PEA is generally considered safe for the use of adults and a couple of studies have also shown less to no risks in children. But larger studies would need to verify the safety of PEA in children. Due to lack of sufficient clinical data, pregnant and breastfeeding women are suggested to follow a caution and consult a doctor before taking any PEA supplements.
PEA has reduced several adverse effects and pain while improving the quality of life. Its studies support the safety and efficiency of the fatty acid and are recommended safe in the clinical use of PEA. The supplement is most effective for compression syndromes including carpal tunnel syndrome and sciatic pain. PEA supplementation is also easy to take and can be administered orally.
Remember to consult with a doctor before taking any PEA supplements as higher doses of PEA can lead to some complications. Although the complications are majorly mild and not serious, PEA should not be used as a substitute for approved medical therapies. However, the above-described benefits and studies were conducted mostly in animals and cells. The stable clinical evidence is still lacking.
More studies in humans are required to determine the effects of PEA on gut health, heart, and histamine release.
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- Hansen HS. Palmitoylethanolamide and other anandamide congeners. Proposed role in the diseased brain. Exp Neurol. 2010;224(1):48–55
- Petrosino S, Iuvone T, Di Marzo V. N-palmitoyl-ethanolamine: biochemistry and new therapeutic opportunities. Biochimie. 2010;92(6):724–7
- Cerrato S, Brazis P, della Valle MF, Miolo A, Puigdemont A. Effects of palmitoylethanolamide on immunologically induced histamine, PGD2 and TNFα release from canine skin mast cells. Vet Immunol Immunopathol. 2010;133(1):9–15
- Palmitoylethanolamide (PEA): Benefits, Dosage, Uses, Supplement