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NSC 74859 (S3I-201) (501919-59-1)

S3I-201, also known as NSC 74859, is a cell-permeable Stat3 inhibitor that binds to the Stat3-SH2 domain, prevents Stat3 phosphorylation/activation, dimerization, and DNA-binding.

Not Intended for Therapeutic Use. For research use only.

CAS: 501919-59-1 Category

NSC 74859 (S3I-201) (501919-59-1) Description:

S3I-201 is an amidobenzoic acid obtained by formal condensation of the carboxy group of [(4-methylbenzene-1-sulfonyl)oxy]acetic acid with the amino group of 4-amino-2-hydroxybenzoic acid. It has a role as a STAT3 inhibitor. It is a monohydroxybenzoic acid, a tosylate ester and an amidobenzoic acid.S3I-201 shows potent inhibition of STAT3 DNA-binding activity with IC50 of 86 μM in cell-free assays, and low activity towards STAT1 and STAT5.

NSC 74859 (S3I-201) (501919-59-1) Specifications:

Product Name NSC 74859(S3I-201)
Chemical Name 501919-59-1; Nsc 74859; S3I-201; 2-hydroxy-4-(2-(tosyloxy)acetamido)benzoic acid; S31-201; NSC-74859
Purity >98% (HPLC)
CAS Number 501919-59-1
Molecular Formula C16H15NO7S
Molecular Weight 365.356 g/mol
Monoisotopic Mass 365.057 g/mol
InChi Code InChI=1S/C16H15NO7S/c1-10-2-5-12(6-3-10)25(22,23)24-9-15(19)17-11-4-7-13(16(20)21)14(18)8-11/h2-8,18H,9H2,1H3,(H,17,19)(H,20,21)
Form Powder
Color White to off-white solid powder
Solubility  soluble in DMSO, not soluble in water.
Storage Temp.  0 – 4 C for short term (days to weeks), or -20 C for long term (months)
Shelf life >5 years if stored properly
Handling Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).
Application a cell-permeable Stat3 inhibitor


RIDADR NONH for all modes of transport


  • Pang M, Ma L, Gong R, Tolbert E, Mao H, Ponnusamy M, Chin YE, Yan H, Dworkin LD, Zhuang S. A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy. Kidney Int. 2010 Aug;78(3):257-68. Epub 2010 Jun 2. PubMed PMID: 20520592.
  • Activation of STAT3 integrates common profibrotic pathways to promote fibroblast activation and tissue fibrosis. Chakraborty D et al. Nat Commun. (2017)
  • Role of Stat3 Signaling in Control of EMT of Tubular Epithelial Cells During Renal Fibrosis. Liu J et al. Cell Physiol Biochem. (2017)
  • IL-22 suppresses the infection of porcine enteric coronaviruses and rotavirus by activating STAT3 signal pathway. Xue M et al. Antiviral Res. (2017)