MK-0752 (471905-41-6) Description:
MK0752 is a synthetic small molecule with potential antineoplastic activity. MK0752 inhibits the Notch signaling pathway, which may result in induction of growth arrest and apoptosis in tumor cells in which the Notch signaling pathway is overactivated. The Notch signaling pathway plays an important role in cell-fate determination, cell survival, and cell proliferation. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
MK-0752 is identified as a moderately potent γ-secretase inhibitor, which reduces Aβ40 in a dose-dependent manner with an IC50 of 5 nM in human SH-SY5Y cells. In vitro, MK-0752 blocks Notch-intracellular domain (ICD) cleavage and its subsequent nuclear translocation.
MK-0752 (471905-41-6) Specifications:
|Synonym||MK0752; cis34(3chlorophenyl)sulfonyl4(25difluorophenyl)cyclohexyl propanoicacid.|
|Chemical Name||3-((1r,4s)-4-((4-chlorophenyl)sulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoic acid.|
|Monoisotopic Mass||442.08171 g/mol|
|SMILES||O=C(O)CC[[email protected]]1CC[[email protected]](C2=CC(F)=CC=C2F)(S(=O)(C3=CC=C(Cl)C=C3)=O)CC1|
|Solubility||Soluble in DMSO, not in water|
|Shelf life||>5 years if stored properly|
|Handling||Protect from air and light|
|Application||A moderately potent γ-secretase inhibitor.|