7,8-DIHYDROXYFLAVONE (38183-03-8)

November 23, 2021

Cofttek is the best 7,8-DIHYDROXYFLAVONE powder manufacturer in China. Our factory has a complete production management system (ISO9001 & ISO14001), with a monthly production capacity of 260kg.


Status: In Mass Production
Unit: 1kg/bag, 25kg/Drum

7,8-DIHYDROXYFLAVONE (38183-03-8) Specifications

Name: 7,8-DIHYDROXYFLAVONE
CAS: 38183-03-8
Purity 98%
Molecular Formula: C15H10O4
Molecular Weight: 254.238 g/mol
Melt Point: 250–252°C
Chemical name: Tropoflavin; 7,8-DHF
Synonyms: 7,8-dihydroxyflavone 38183-03-8 7,8-dihydroxy-2-phenyl-4H-chromen-4-one 7,8-Dihydroxyflavone hydrate 7,8-DHF
InChI Key: COCYGNDCWFKTMF-UHFFFAOYSA-N
Half Life: < 30 minutes (in mice)
Solubility: 7,8-DHF is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF).
Storage Condition: 0 – 4 C for short term (days to weeks), or -20 C for long term (months)
Application: 7,8-DHF is a synthetic flavonoid which can reach the brain and activate a receptor (TrkB) that promotes neuronal growth. Some animal evidence suggests that 7,8-DHF may have some cognitive and motor benefits and may be nootropic.
Appearance: Yellow powder

 

What is 7,8-DIHYDROXYFLAVONE (38183-03-8)?

7,8-Dihydroxyflavone (7,8-DHF) is a flavone found in plants. It was discovered while searching for molecules that imitate the function of brain-derived neurotrophic factor (BDNF).

BDNF promotes the growth of neurons and synapses (synaptogenesis) and is very important for normal brain function. Lower amounts of BDNF are observed in diseases such as depression, Alzheimer’s, Parkinson’s, and schizophrenia.

Studies in animals show that 7,8-DHF could potentially help with brain repair, long-term memory, depression, and neurodegenerative diseases.

 

7,8-DIHYDROXYFLAVONE (38183-03-8) benefits

Memory and Learning

7,8-DHF improved object recognition (a test used to determine learning and memory) in healthy rats when given immediately following and three hours after learning. It also improved memory in mice with dementia. In rat models of post-traumatic stress disorder (PTSD), 7,8-DHF prevented stress-related memory impairment. 7,8-DHF also improved memory in aging rats.

 

Brain Repair

7,8-DHF promoted the repair of damaged neurons. It also increased the production of new neurons in the brains of adult mice after brain injury and promoted neuron growth in aged mice. Similarly, 7,8-DHF, along with exercise, improved brain function in rats that experienced traumatic brain injury.

 

Alzheimer’s Disease

In animal models for Alzheimer’s disease, 7,8-DHF:

Reduced amyloid plaque formation

Reduced oxidative stress

Prevented loss of synapses

Prevented memory deficits and preserved cognitive function

However, another study found no benefits in treating mice with Alzheimer’s-like brain damage with 7,8-DHF.

 

Parkinson’s Disease

7,8-DHF improved motor function and prevents the loss of dopamine-related neurons in a mouse model of Parkinson’s disease.

It also prevents the death of dopamine-sensitive neurons in monkey models of Parkinson’s disease.

 

7,8-DIHYDROXYFLAVONE (38183-03-8) uses?

7,8-Dihydroxyflavone (7,8-DHF) is a naturally occurring flavonoid. It has shown efficacy against several nervous-system diseases, including Alzheimer’s, Parkinson’s, and Huntington’s. 7,8-Dihydroxyflavone (7,8-DHF) is thought to be a promising therapeutic agent for various neurodegenerative diseases.

 

7,8-DIHYDROXYFLAVONE (38183-03-8) dosage

7,8-DHF can be purchased as capsules/pills, or powder.

There is no safe and effective dose of 7,8-DHF because no sufficiently powered study has been conducted to find one. The most common dosage in commercially available supplements is 10 – 30 mg per day.

 

7,8-DIHYDROXYFLAVONE powder for sale(Where to Buy 7,8-DIHYDROXYFLAVONE powder in bulk)

Our company enjoys long term relationships with our clients because we focus on customer service and providing great products. If you are interested in our product, we are flexible with the customization of orders to suit your specific need and our quick lead time on orders guarantees you’ll have great tasting our product on-time. We also focus on value-added services. We are available for service questions and information to support your business.

We are an professional 7,8-DIHYDROXYFLAVONE powder supplier for several years, we supply products with competitive price, and our product is of the highest quality and undergoes strict, independent testing to ensure that it is safe for consumption around the world.

 

References

  1. Schliebs R, Arendt T (2006) The significance of the cholinergic system in the brain during aging and in Alzheimer’s disease. J Neural Transm (Vienna) 113:1625–1644.
  2. Corbett A, Ballard C (2012) New and emerging treatments for Alzheimer’s disease. Expert Opin Emerg Drugs 17:147–156.
  3. Giacobini E, Gold G (2013) Alzheimer disease therapy: Moving from amyloid-β to tau. Nat Rev Neurol 9:677–686.
  4. Zuccato C, Cattaneo E (2009) Brain-derived neurotrophic factor in neurodegenerative diseases. Nat Rev Neurol 5:311–322.