Citicoline Sodium (CDP Choline Sodium)(33818-15-4) Specifications
|Name:||Citicoline Sodium (CDP Choline Sodium)|
|Molecular Weight:||510.308 g/mol|
|Chemical name:||Citicoline Sodium; Cdp-choline sodium|
|Synonyms:||Sodium [[(2S,3R,4S,5S)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]2-(trimethylazaniumyl)ethyl phosphate|
|Half Life:||56 hours|
|Solubility:||Soluble in DMSO, Water (Slightly)|
|Storage Condition:||Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).|
|Application:||Citicoline Sodium is a neuroprotective agent and dietary supplement|
|Appearance:||White Solid powder|
Citicoline Sodium (33818-15-4) NMR Spectrum
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What is Citicoline Sodium (CDP Choline Sodium)(33818-15-4) ?
Citicoline Sodium (CDP-choline Sodium, cytidine 5′-diphosphocholine) powder is a water soluble nutrient which serves as a precursor to both choline and cytidine within the brain (which later converts to uridine). To humans,Citicoline Sodium is an essential nutrient as its role in reducing the riskof neural tube defects, fatty liver disease, and other pathologies have been documented. CDP-choline Sodium is one of the three choline-containing phospholipids that can be orally supplemented (the other two being alpha-GPC and phosphatidylcholine).
Citicoline Sodium (CDP Choline Sodium)(33818-15-4) benefits
CDP-choline activates the biosynthesis of structural phospholipids in the neuronal membranes, increases cerebral metabolism and acts on the levels of various neurotransmitters. Thus, it has been experimentally proven that CDP-choline increases noradrenaline and dopamine levels in the CNS.
This supplement is catered towards preventing or treating memory impairments associated with aging due to the fact that both of the molecules it confers are neuroprotective and potentially enhance learning. While it appears to be more effective than phosphatidylcholine (PC) at this role, in part due to also increasing PC synthesis in the brain, its potency is somewhat comparable to that of Alpha-GPC.
Citicoline Sodium (CDP Choline Sodium)(33818-15-4) uses
CDP-choline has some other potential uses in relation to cognition. It is commonly used as a memory enhancer in youth, but despite some rodent studies suggesting that this is possible with oral CDP-choline, there are no human studies in youth at this point in time. One study has noted an increase in attention with low dose CDP-choline (which needs to be replicated), and CDP-choline may have roles as an anti-addictive compound against both cocaine and (preliminary evidence suggests) food as well..
Citicoline Sodium (CDP Choline Sodium)(33818-15-4) Application
Citicoline Sodium (CDP Choline Sodium) powder is a neuroprotective agent. It acts by enhancing cellular communication, stimulating the synthesis of SAMe, and increasing glucose metabolis. Citicoline Sodium (CDP Choline Sodium) powder is a naturally occurring nucleotide; intermediate in the major pathway of lecitin biosynthesis. Neuroprotective. It is used in the treatment of ischemic stroke and head trauma. Neuroprotectiveproduct. Citicholine exhibits protective effects in cerebral ischemia, traumatic brain injury, and memory disorders. Recently showed efficacy against dementia when given with AchEIs (Acetylcholinesterase inhibitor). Depicts Neuroprotective, acnticonvulsant activity and sedative effect at a dose of 150mg/kg in rats. Showed protection against aluminum induced cognitive impairment in rats reducing elevated glutamate level, oxidativestress and NO overproduction in the hippocampus.
Citicoline Sodium (CDP Choline Sodium)(33818-15-4) powder for sale
(Where to Buy Citicoline Sodium (CDP Choline Sodium)(33818-15-4) powder in bulk)
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 Tyurenkov IN, Kurkin DV, Bakulin DA, Volotova EV, Chafeev MA. [Cerebroprotective activity of metformin, gosogliptin, citicoline and a novel GPR119 agonist in cerebral ischemia under experimental diabetes mellitus]. Zh Nevrol Psikhiatr Im S S Korsakova. 2017;117(12. Vyp. 2):53-59. doi: 10.17116/jnevro201711712253-59. Russian. PubMed PMID: 29411746.
 Jiang JJ, Xie YM, Zhang Y, Zhang YK, Wang ZM, Han B. [Clinical medication characteristics of Shuxuening injection in treatment of cerebral infarction research based on registration]. Zhongguo Zhong Yao Za Zhi. 2016 Dec;41(24):4516-4520. doi: 10.4268/cjcmm20162407. Chinese. PubMed PMID: 28936832.
 Liu Y, Wang J, Xu C, Chen Y, Yang J, Liu D, Niu H, Jiang Y, Yang S, Ying H. Efficient multi-enzyme-catalyzed CDP-choline production driven by an ATP donor module. Appl Microbiol Biotechnol. 2017 Feb;101(4):1409-1417. doi: 10.1007/s00253-016-7874-0. Epub 2016 Oct 13. PubMed PMID: 27738720.
 Giménez R, Raïch J, Aguilar J (Nov 1991). “Changes in brain striatum dopamine and acetylcholine receptors induced by chronic CDP-choline treatment of aging mice”. British Journal of Pharmacology. 104 (3): 575–8. doi:1111/j.1476-5381.1991.tb12471.x. PMC1908237. PMID1839138.
 Tardner, P. (2020-08-30). “The use of citicoline for the treatment of cognitive decline and cognitive impairment: A meta-analysis of pharmacological literature • International Journal of Environmental Science & Technology”. International Journal of Environmental Science & Technology. Retrieved 2020-08-31.