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HER2&FLT3

TCS359 (301305-73-7)

TCS-359 is a potent inhibitor of FLT3 with IC50 of 42 nM. TCS 359 (Fms-like) tyrosine kinase (FLT3) is a cell-surface receptor with important roles in stem cell development, hematopoiesis.

Not Intended for Therapeutic Use. For research use only.

CAS: 301305-73-7 Category

TCS359 (301305-73-7) Description:

TCS 359, a 2-acylaminothiophene-3-carboxamide, is a potent inhibitor of FLT3 with IC50 of 42 nM. IC50 Value: 42 nM [1] Target: Flt3 in vitro: TCS 359, a 2-acylaminothiophene-3-carboxamide, is a potent inhibitor of FLT3 with IC50 of 42 nM. TCS 359 inhibits MV4-11 proliferation with IC50 of 340 nM. TCS 359 is highly selective for FLT3 against a panel of kinases [1].

TCS359 (301305-73-7) Specifications:

Product Name TCS359
Chemical Name TCS 359; 301305-73-7; Flt-3 inhibitor; 2-(3,4-dimethoxybenzamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide; TCS-359; CHEMBL210833
Purity ≥98% (HPLC)
CAS Number 301305-73-7
Molecular Formula C18H20N2O4S
Molecular Weight 360.428 g/mol
Monoisotopic Mass 360.114 g/mol
InChIKey FSPQCTGGIANIJZ-UHFFFAOYSA-N
InChi Code InChI=1S/C18H20N2O4S/c1-23-12-8-7-10(9-13(12)24-2)17(22)20-18-15(16(19)21)11-5-3-4-6-14(11)25-18/h7-9H,3-6H2,1-2H3,(H2,19,21)(H,20,22)
SMILES O=C(C1=C(NC(C2=CC=C(OC)C(OC)=C2)=O)SC3=C1CCCC3)N
Form Powder
Color N/A
Solubility  May Soluble in DMSO
Storage Temp.  -20°C
Shelf life >2 years if stored properly
Handling Protect from air and moisture
Application a potent inhibitor

 


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RIDADR NONH for all modes of transport

References:

  • Grafone, T., Palmisano, M., Nicci, C., et al. An overview on the role of FLT3-tyrosine kinase receptor in acute myeloid leukemia: Biology and treatment Oncol.Rev. 6(1), 64-74 (2012).
  • Lyman, S.D., and Jacobsen, S.E.W. c-kit ligand and Flt3 ligand: Stem/progenitor cell factors with overlapping yet distinct activities Blood 91(4), 1101-1134 (1998).
  • Patch, R.J., Baumann, C.A., Liu, J., et al. Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3 Bioorganic & Medicinal Chemistry Letters 16(12), 3282-3286 (2006).
  • Bennett, C.A., Winters, A.C., Barretti, N.N., et al. Molecular targeting of MLL-rearranged leukemia cell lines with the synthetic peptide PFWT synergistically enhances the cytotoxic effect of established chemotherapeutic agents Leukemia Research 33(7), 937-947 (2009).
  • Patch RJ, Baumann CA, Liu J, Gibbs AC, Ott H, Lattanze J, Player MR. Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3282-6. Epub 2006 Mar 31. PubMed PMID: 16580199.

1 review for TCS359 (301305-73-7)

  1. Cofttek

    Never had such good experience before,The TCS359 (301305-73-7) is high purity,also customer service is pretty nice !gotta try!!

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