Nicotinamide Riboside Chloride (NR) (23111-00-4) Manufacturer - Cofttek

Nicotinamide Riboside Chloride (NR) (23111-00-4)

April 7, 2020

Nicotinamide riboside, also known as NR and SRT647, is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide or NAD+. NR blocks degeneration of surgically severed dorsal root ganglion neurons ex vivo and protects against noise-induced hearing loss in living mice.

 


Status: In Mass Production
Unit: 25kg/Drum

 

Nicotinamide Riboside Chloride (NR) (23111-00-4) video

 

Nicotinamide Riboside Chloride (NR) Specifications

Name: Nicotinamide Riboside Chloride (NR)
CAS: 23111-00-4
Purity 98%
Molecular Formula: C11H15ClN2O5
Molecular Weight: 290.7 g/mol
Melt Point: 115-125℃
Chemical name: 3-carbamoyl-1-((3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium chloride
Synonyms: Nicotinamide riboside; SRT647; SRT-647; SRT 647; Nicotinamide Riboside Triflate, α/β mixture
InChI Key: YABIFCKURFRPPO-FSDYPCQHSA-N
Half Life: 2.7 hours
Solubility: Soluble in DMSO, Methanol, Water
Storage Condition: 0 – 4 C for short term (days to weeks), or -20 C for long term (months)
Application: Nicotinamide riboside is claimed to be a new form pyridine-nucleoside of vitamin B₃ that functions as a precursor to nicotinamide adenine dinucleotide or NAD+.
Appearance: Off White to Pale Yellow powder

 

What is Nicotinamide Riboside Chloride (NR) CAS 23111-00-4?

Nicotinamide riboside, also known as NR and SRT647, is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide or NAD+. NR blocks degeneration of surgically severed dorsal root ganglion neurons ex vivo and protects against noise-induced hearing loss in living mice. Nicotinamide riboside prevents muscle, neural and melanocyte stem cell senescence. Increased muscular regeneration in mice has been observed after treatment with nicotinamide riboside, leading to speculation that it might improve regeneration of organs such as the liver, kidney, and heart. Nicotinamide riboside also lowers blood glucose and fatty liver in prediabetic and type 2 diabetic models while preventing the development of diabetic peripheral neuropathy. Note: Nicotinamide Riboside chloride is a α/β mixture.

 

 

Nicotinamide Riboside Chloride (NR) CAS 23111-00-4 benefits

Nicotinamide nucleosides are precursors of nicotinamide adenine dinucleotide (NAD) and represent a source of vitamin B3. Recent studies have shown that taking in a greater amount of nicotinamide nucleosides naturally present in foods can provide new health benefits. For example, nicotinamide nucleosides have been implicated in increasing tissue NAD concentration and inducing insulin sensitivity as well as enhancing sirtuin function. Its ability to increase NAD production suggests that nicotinamide nucleosides can also improve mitochondrial health, stimulate mitochondrial function, and induce the production of new mitochondria. Other studies using nicotinamide nucleosides in the Alzheimer’s disease model have shown that the molecule is bioavailable to the brain and may provide neuroprotection by stimulating brain NAD synthesis.

Nicotinamide Riboside Chloride also can Reduce weight: Studies have shown that by increasing energy metabolism, you can effectively reduce the high-fat diet induced weight gain. In order to evaluate the nicotinamide ribose mechanism of NR promoting weight loss, the researchers measured the liver mitochondrial function associated with caloric intake, activity, calories, waist circumference, resting metabolic rate, body composition, glucose tolerance, insulin sensitivity and various biochemical and metabolomics parameters. These data and the new weight loss mechanism by malabsorption, excretion of biological markers for tracking. The researchers reported that mice fed nicotinamide nicotinamide  supplements were significantly more likely to lose weight relative to mice that did not supplement nicotinamide

 

 

Nicotinamide Riboside Chloride (NR) CAS 23111-00-4 Mechanism Of Action?

Nicotinamide Riboside Chloride (NR) nucleosides are precursors of nicotinamide adenine dinucleotide (NAD) and represent a source of vitamin B3. Recent studies have shown that taking in a greater amount of nicotinamide nucleosides naturally present in foods can provide new health benefits. For example, nicotinamide nucleosides have been implicated in increasing tissue NAD concentration and inducing insulin sensitivity as well as enhancing sirtuin function. Its ability to increase NAD production suggests that nicotinamide nucleosides can also improve mitochondrial health, stimulate mitochondrial function, and induce the production of new mitochondria. Other studies using nicotinamide nucleosides in the Alzheimer’s disease model have shown that the molecule is bioavailable to the brain and may provide neuroprotection by stimulating brain NAD synthesis..

 

 

Nicotinamide Riboside Chloride (NR) CAS 23111-00-4 Application

Preclinical studies have shown that the addition of nicotinamide ribose can not only increase NAD+ levels safely, but also maximize the utilization of NAD+ in humans, which is not possible with other vitamin B3.Studies have shown that once nicotinamide ribose appears in the cell, the body rapidly transforms it into NAD+. These NAD+ then stimulate the process of intracellular initiation of energy production by mitochondria

Nicotinamide Riboside Chloride can enhance mitochondrial function, which is shown to enhance the expression of mitochondrial electron transport chain proteins, enhance mitochondrial membrane potential, and increase the rate of oxidative respiration and intracellular ATP levels. This may be accompanied by higher levels of mitochondrial regeneration. Mitochondrial function declines as we age, and this is the sign of the aging of stem cells that we find. NR can enhance the function of mitochondria and inhibit the senescence of stem cells.

 

Nicotinamide Riboside Chloride (NR) powder for sale(Where to Buy Nicotinamide Riboside Chloride (NR) powder in bulk)

Our company enjoys long term relationships with our clients because we focus on customer service and providing great products. If you are interested in our product, we are flexible with the customization of orders to suit your specific need and our quick lead time on orders guarantees you’ll have great tasting our product on-time. We also focus on value-added services. We are available for service questions and information to support your business.

 

We are an professional Nicotinamide Riboside Chloride (NR) powder supplier for several years, we supply products with competitive price, and our product is of the highest quality and undergoes strict, independent testing to ensure that it is safe for consumption around the world.

 

References

  • Chi Y, Sauve AA. Nicotinamide riboside, a trace nutrient in foods, is a vitamin B3 with effects on energy metabolism and neuroprotection. Curr Opin Clin Nutr Metab Care. 2013 Nov;16(6):657-61. doi: 10.1097/MCO.0b013e32836510c0. Review. PubMed PMID: 24071780.
  • Bogan KL, Brenner C. Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition. Annu Rev Nutr. 2008;28:115-30. doi: 10.1146/annurev.nutr.28.061807.155443. Review. PubMed PMID: 18429699.
  • Ghanta S, Grossmann RE, Brenner C. Mitochondrial protein acetylation as a cell-intrinsic, evolutionary driver of fat storage: chemical and metabolic logic of acetyl-lysine modifications. Crit Rev Biochem Mol Biol. 2013 Nov-Dec;48(6):561-74. doi: 10.3109/10409238.2013.838204. Review. PubMed PMID: 24050258; PubMed Central PMCID: PMC4113336.