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Akt &GSK-3

Bikinin (188011-69-0)

Bikinin(Abrasin) is a potent inhibitor of plant GSK-3/Shaggy-like kinase; activates BR signaling downstream of the BR receptor.

Not Intended for Therapeutic Use. For research use only.

CAS: 188011-69-0 Category

Bikinin (188011-69-0) Description:

Bikinin is a GSK-3 inhibitor. Bikinin directly binds the GSK3 BIN2 and acts as an ATP competitor. Bikinin inhibits the activity of six other Arabidopsis GSK3s. Glycogen synthase kinase 3 (GSK3) is a key regulator in signaling pathways in both animals and plants. Plant GSK-3/Shaggy-like kinases are key players in brassinosteroid (BR) signalling which impact on plant development and participate in response to wounding, pathogens and salt stress.

Bikinin (188011-69-0) Specifications:

Product Name Bikinin
Synonym Bikinin
Chemical Name 4-((5-bromopyridin-2-yl)amino)-4-oxobutanoic acid
Drug Class Antineoplastics
Purity ≥98% (HPLC)
CAS Number 188011-69-0
Molecular Formula C9H9BrN2O3
Molecular Weight 273.09
Monoisotopic Mass 271.97965 g/mol
MDL number MFCD00116442
InChIKey XFYYQDHEDOXWGA-UHFFFAOYSA-N
InChi Code InChI=1S/C9H9BrN2O3/c10-6-1-2-7(11-5-6)12-8(13)3-4-9(14)15/h1-2,5H,3-4H2,(H,14,15)(H,11,12,13)
SMILES BrC1=CN=C(NC(CCC(O)=O)=O)C=C1
Form Powder
Color white to tan
Solubility  Soluble in DMSO, not soluble in water
Storage Temp.  0 – 4 C for short term (days to weeks), or -20 C for long term (months)
Shelf life >2 years if stored properly
Handling Protect from air and moisture
Application Bikinin(Abrasin) is a potent inhibitor of plant GSK-3

 


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RIDADR NONH for all modes of transport

References:

[1]. Mills-Lujan K, Andrews DL, Chou CW, Deom CM. The roles of phosphorylation and SHAGGY-like protein kinases in geminivirus C4 protein induced hyperplasia. PLoS One. 2015 Mar 27;10(3):e0122356. doi: 10.1371/journal.pone.0122356. eCollection 2015. PubMed PMID: 25815729; PubMed Central PMCID: PMC4376871.

[2]. Kondo Y, Fujita T, Sugiyama M, Fukuda H. A novel system for xylem cell differentiation in Arabidopsis thaliana. Mol Plant. 2015 Apr;8(4):612-21. doi: 10.1016/j.molp.2014.10.008. Epub 2014 Dec 13. PubMed PMID: 25624147.

[3]. Chung Y, Kwon SI, Choe S. Antagonistic regulation of Arabidopsis growth by brassinosteroids and abiotic stresses. Mol Cells. 2014 Nov;37(11):795-803. doi: 10.14348/molcells.2014.0127. Epub 2014 Nov 5. PubMed PMID: 25377253; PubMed Central PMCID: PMC4255099.

[4]. Rozhon W, Wang W, Berthiller F, Mayerhofer J, Chen T, Petutschnig E, Sieberer T, Poppenberger B, Jonak C. Bikinin-like inhibitors targeting GSK3/Shaggy-like kinases: characterisation of novel compounds and elucidation of their catabolism in planta. BMC Plant Biol. 2014 Jun 19;14:172. doi: 10.1186/1471-2229-14-172. PubMed PMID: 24947596; PubMed Central PMCID: PMC4078015.

[5].Cai Z, Liu J, Wang H, Yang C, Chen Y, Li Y, Pan S, Dong R, Tang G, Barajas-Lopez Jde D, Fujii H, Wang X. GSK3-like kinases positively modulate abscisic acid signaling through phosphorylating subgroup III SnRK2s in Arabidopsis. Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9651-6. doi: 10.1073/pnas.1316717111. Epub 2014 Jun 13. PubMed PMID: 24928519; PubMed Central PMCID: PMC4084465.