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PDGFR&FGFR

FGFR4-IN-1 (1708971-72-5)

FGFR4-IN-1 is a potent and selective FGFR4 inhibitor. FGFR4 may be a novel therapeutic target for gastric cancer. FGFR4-IN-1 significantly inhibits the proliferation of HuH-7 hepatocellular carcinoma cells with IC50 of 7.8 nM.

Not Intended for Therapeutic Use. For research use only.

CAS: 1708971-72-5 Category

FGFR4-IN-1 (1708971-72-5) Description:

FGFR4-IN-1 is a potent and selective FGFR4 inhibitor. FGFR4 may be a novel therapeutic target for gastric cancer. FGFR4-IN-1 significantly inhibits the proliferation of HuH-7 hepatocellular carcinoma cells with IC50 of 7.8 nM.

FGFR4-IN-1 (1708971-72-5) Specifications:

Product Name FGFR4-IN-1
Synonym FGFR4-IN-1; FGFR4-IN1; FGFR4-IN 1.
Chemical Name N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((3-oxomorpholino)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide
Drug Class N/A
Purity >98% (or refer to the Certificate of Analysis)
CAS Number 1708971-72-5
Molecular Formula C24H27N7O5
Molecular Weight 493.524
Monoisotopic Mass
493.207 g/mol

 

MDL number N/A
InChIKey ZTYSXMGILYNNJX-UHFFFAOYSA-N
InChi Code InChI=1S/C24H27N7O5/c1-35-7-4-26-19-10-21(27-12-18(19)11-25)29-24(34)31-5-2-3-16-9-17(20(14-32)28-23(16)31)13-30-6-8-36-15-22(30)33/h9-10,12,14H,2-8,13,15H2,1H3,(H2,26,27,29,34)
SMILES O=C(N1CCCC2=CC(CN3C(COCC3)=O)=C(C=O)N=C12)NC4=NC=C(C#N)C(NCCOC)=C4
Form Solid powder
Color N/A
Solubility  Soluble in DMSO
Storage Temp.  Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shelf life >2 years if stored properly
Handling Protect from air and moisture
Application FGFR4-IN-1 is a potent inhibiotr of FGFR4 with IC50 of 0.7 nM.

 


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RIDADR NONH for all modes of transport

References:

1. Ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors. WO 2015059668 A1

1 review for FGFR4-IN-1 (1708971-72-5)

  1. Rated 5 out of 5

    Cofttek

    Never had such good experience before,The FGFR4-IN-1 (1708971-72-5) is high purity,also customer service is pretty nice !gotta try!!

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