|Molecular Weight:||274.36 g/mol|
|Melting Point:||132-134 ºC|
|Synonyms:||Adelmidrol 1675-66-7 N,N’-bis(2-hydroxyethyl)nonanediamide AdelMitrol UNII-1BUC3685QU More…|
|Solubility:||Soluble in water; Ethanol; DMSO|
|Storage Condition:||0 – 4 C for short term (days to weeks), or -20 C for long term (months)|
|Application:||It is used extensively in Italy in veterinary medicine to treat skin inflammation. In 2015, it was found the compound also exerts anti-inflammatory action given systemically in 10 mg per kg bodyweight.|
What is Adelmidrol (1675-66-7)?
Adelmidrol is the semisynthetic diethanolamide derivative of azelaic acid, and has a symmetrical chemical structure. It classed as an amide, and is similar to palmitoylethanolamide, the parent molecule in the ALIAmide class of drugs. ALIAmides are group of fatty acid derivatives with cannabimimetic properties which have anti-inflammatory and analgesic effects and are thought to act by reducing mast cell activation. Adelmidrol is an anti-inflammatory ethanolamide derivative of azelaic acid.
Adelmidrol (1675-66-7) benefits
Adelmidrol is the synthetic derivate of azelaic acid, a naturally occurring saturated dicarboxylic acid, that is found in some whole grains and in trace amounts in the human body. Chemically, ademidrol is the N,N-bis (2-hydroxyethyl) non anediamide and it is an amphiphilic or amphipathic compound, possessing both hydrophilic and hydrophobic properties, that favor its solubility both in aqueous and organic media. Adelmidrol belongs to the aliamide family, a group of fatty acid derivatives with cannabimimetic properties, able to control mast cell (MC) hyperreactivity in several pathophysiological and pathological conditions. Pro-inflammatory NF-κB pathway were markedly reduced by treatment with adelmidrol. The anti-inflammatory effect of adelmidrol appeared to be related on PPAR-gamma activation. Adelmidrol is topically effective for human inflammatory skin disorders and is able to modulate the inflammatory response in human keratinocytes. The combination of hyaluronic acid and adelmidrol improves the signs of osteoarthritis induced by monosodium iodoacetate.
Adelmidrol (1675-66-7) Application?
Adelmidrol is a semisynthetic derivative of azelaic acid and analogue of the anti-inflammatory compound palmitoylethanolamide (PEA), an aliamide and member of the family of fatty acid amide signaling molecules with cannabimimetic properties. The anti-inflammatory and antinociceptive effects of the aliamides PEA and adelmidrol have been demonstrated in numerous pre-clinical studies, both in vitro and in vivo. Their actions are thought to be due, at least in part, to their ability to down-modulate mast cell activation and mast cell mediator release in pathophysiological and pathological conditions.
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- Cerrato, Santiago; Brazis, Pilar; della Valle, Maria Federica; Miolo, Alda; Puigdemont, Anna (2012). “Inhibitory effect of topical Adelmidrol on antigen-induced skin wheal and mast cell behavior in a canine model of allergic dermatitis”. BMC Veterinary Research. 8 (1): 230. doi:10.1186/1746-6148-8-230. PMC 3540011. PMID 23181761.
- Cordaro, M; Impellizzeri, D; Gugliandolo, E; Siracusa, R; Crupi, R; Esposito, E; Cuzzocrea, S (2016). “Adelmidrol, a Palmitoylethanolamide Analogue, as a New Pharmacological Treatment for the Management of Inflammatory Bowel Disease”. Molecular Pharmacology. 90 (5): 549–561. doi:10.1124/mol.116.105668. PMID 27625036.
- Abramo, F; Salluzzi, D; Leotta, R; Auxilia, S; Noli, C; Miolo, A; Mantis, P; Lloyd, D. H (2008). “Mast cell morphometry and densitometry in experimental skin wounds treated with a gel containing adelmidrol: A placebo controlled study”. Wounds : A Compendium of Clinical Research and Practice. 20 (6): 149–57. PMID 25942520.