Cofttek holdings limited

Wnt&Beta catenin

CCT251545 (1661839-45-7)

CCT251545, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Not Intended for Therapeutic Use. For research use only.

CAS: 1661839-45-7 Category

CCT251545 (1661839-45-7) Description

CCT251545 is a potent small-molecule inhibitor of WNT signaling with good oral pharmacokinetics. CCT251545 is a potent and selective chemical probe for the human Mediator complex-associated protein kinases CDK8 and CDK19 with >100-fold selectivity over 291 other kinases. In contrast to type II inhibitors of CDK8 and CDK19, CCT251545 displays potent cell-based activity. CCT251545 alters WNT pathway-regulated gene expression and other on-target effects of modulating CDK8 and CDK19, including expression of genes regulated by STAT1.

 

CCT251545 (1661839-45-7) Specifications

Product Name CCT251545
Synonym CCT251545; CCT 251545; CCT-251545; CAS#1661839-45-7
Chemical Name 8-(3-chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one
Drug Class N/A
Purity ≥ >98%
CAS Number  1661839-45-7
Molecular Formula C23H24ClN5O
Molecular Weight 421.93
Monoisotopic Mass  421.1669
MDL number SML0795
InChIKey LBFYQISQYCGDDW-UHFFFAOYSA-N
InChi Code InChI=1S/C23H24ClN5O/c1-28-15-18(12-27-28)16-2-4-17(5-3-16)19-13-25-14-20(24)21(19)29-10-7-23(8-11-29)6-9-26-22(23)30/h2-5,12-15H,6-11H2,1H3,(H,26,30)
SMILES  O=C1NCCC12CCN(C3=C(Cl)C=NC=C3C4=CC=C(C5=CN(C)N=C5)C=C4)CC2
Form N/A
Color N/A
Solubility  Soluble in DMSO
Storage Temp.  0 – 4 C for short term (days to weeks), or -20 C for long term (months).
Shelf life > >2 years if stored properly
Handling N/A
Application N/A

 


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