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GPCR&G protein

SA-4503 (165377-44-6)

SA4503 2Hcl(AGY-94806 2Hcl; Cutamesine 2Hcl) is a selective sigma 1 receptor(σ1R) agonist; high affinity for the sigma 1 receptor subtype labeled by (+)-[3H]pentazocine (IC50 = 17.4 +/- 1.9 nM); 100-fold less affinity for the sigma 2 receptor.

Not Intended for Therapeutic Use. For research use only.

CAS: 165377-44-6 Category

SA-4503 (165377-44-6) Description:

 Cutamesine, also known as SA-4503 and AGY94806, is a sigma-1 receptor agonist under development for recovery enhancement after acute ischemic stroke. Cutamesine protects against retinal cell death in vitro and in vivo by the agonistic effect of sigma-1 receptor. Therefore, sigma-1 receptor may have a potential as a therapeutic target in retinal diseases mediated by photoreceptor degeneration. .

SA-4503 (165377-44-6) Specifications:

Product Name SA-4503
Synonyms  SA4503; SA 4503; SA-4503;.
Chemical Names 165377-44-6; 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride; SA4503 dihydrochloride; Cutamesine dihydrochloride; SA 4503 dihydrochloride; SA-4503 dihydrochloride
Purity >98%
CAS Number  165377-44-6
Molecular Formula C23H34Cl2N2O2
Molecular Weight 441.437 g/mol
Monoisotopic Mass 440.2 g/mol
InChIKey XWOXAKBQEMQMFH-UHFFFAOYSA-N
InChi Code InChI=1S/C23H32N2O2.2ClH/c1-26-22-11-10-21(19-23(22)27-2)12-14-25-17-15-24(16-18-25)13-6-9-20-7-4-3-5-8-20;;/h3-5,7-8,10-11,19H,6,9,12-18H2,1-2H3;2*1H
SMILES COC1=C(C=C(C=C1)CCN2CCN(CC2)CCCC3=CC=CC=C3)OC.Cl.Cl
Form Powder
Color N/A
Solubility  may be formulated in DMSO
Storage Temp.  −20°C
Shelf life >2 years if stored properly.
Handling Dry, dark
Application a sigma-1 receptor agonist

 


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RIDADR NONH for all modes of transport

References:

  • 1: Shimazawa M, Sugitani S, Inoue Y, Tsuruma K, Hara H. Effect of a sigma-1 receptor agonist, cutamesine dihydrochloride (SA4503), on photoreceptor cell death against light-induced damage. Exp Eye Res. 2015 Mar;132:64-72. doi: 10.1016/j.exer.2015.01.017. Epub 2015 Jan 20. PubMed PMID: 25616094.
  • 2: Yamashita D, Sun GW, Cui Y, Mita S, Otsuki N, Kanzaki S, Nibu K, Ogawa K, Matsunaga T. Neuroprotective effects of cutamesine, a ligand of the sigma-1 receptor chaperone, against noise-induced hearing loss. J Neurosci Res. 2015 May;93(5):788-95. doi: 10.1002/jnr.23543. Epub 2015 Jan 22. PubMed PMID: 25612541.
  • 3: Ramakrishnan NK, Schepers M, Luurtsema G, Nyakas CJ, Elsinga PH, Ishiwata K, Dierckx RA, van Waarde A. Cutamesine Overcomes REM Sleep Deprivation-Induced Memory Loss: Relationship to Sigma-1 Receptor Occupancy. Mol Imaging Biol. 2015 Jun;17(3):364-72. doi: 10.1007/s11307-014-0808-2. PubMed PMID: 25449772.
  • 4: Urfer R, Moebius HJ, Skoloudik D, Santamarina E, Sato W, Mita S, Muir KW; Cutamesine Stroke Recovery Study Group. Phase II trial of the Sigma-1 receptor agonist cutamesine (SA4503) for recovery enhancement after acute ischemic stroke. Stroke. 2014 Nov;45(11):3304-10. doi: 10.1161/STROKEAHA.114.005835. Epub 2014 Sep 30. PubMed PMID: 25270629.
  • 5: Fujimoto M, Hayashi T, Urfer R, Mita S, Su TP. Sigma-1 receptor chaperones regulate the secretion of brain-derived neurotrophic factor. Synapse. 2012 Jul;66(7):630-9. doi: 10.1002/syn.21549. Epub 2012 Mar 16. PubMed PMID: 22337473; PubMed Central PMCID: PMC3824965.
  • 6: Niitsu T, Iyo M, Hashimoto K. Sigma-1 receptor agonists as therapeutic drugs for cognitive impairment in neuropsychiatric diseases. Curr Pharm Des. 2012;18(7):875-83. Review. PubMed PMID: 22288409.

1 review for SA-4503 (165377-44-6)

  1. Rated 5 out of 5

    Cofttek

    Never had such good experience before,The SA-4503 (165377-44-6) is high purity,also customer service is pretty nice !gotta try!!

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