Cofttek holdings limited

Wnt&Beta catenin

ETC-159 (1638250-96-0)

ETC-159, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received

Not Intended for Therapeutic Use. For research use only.

CAS: 1638250-96-0 Category

ETC-159 (1638250-96-0) Description

ETC-159, also known as ETC-1922159, is a potent, selective and orally available PORCN inhibitor. ETC-159 blocks the secretion and activity of all Wnts. ETC-159 is remarkably effective in treating RSPO-translocation bearing colorectal cancer (CRC) patient-derived xenografts. Inhibition of Wnt signaling by PORCN inhibition holds promise as differentiation therapy in genetically defined human cancers. Enhanced sensitivity to Wnts is an emerging hallmark of a subset of cancers, defined in part by mutations regulating the abundance of their receptors.

ETC-159 (1638250-96-0) Specifications

Product Name ETC-159
Synonym  ETC-159; ETC159; ETC 159; ETC-1922159; ETC 1922159; ETC1922159.
Chemical Name 1,3-dimethyl-7-((6-phenylpyridazin-3-yl)glycyl)-3,4,5,7-tetrahydro-1H-purine-2,6-dione
Drug Class N/A
Purity ≥ >98%
CAS Number 1638250-96-0
Molecular Formula C19H19N7O3
Molecular Weight 393.407
Monoisotopic Mass 393.15494
MDL number SML0795
InChIKey COEZTQWWLJCBEC-UHFFFAOYSA-N
InChi Code  InChI=1S/C19H19N7O3/c1-24-17-16(18(28)25(2)19(24)29)26(11-21-17)15(27)10-20-14-9-8-13(22-23-14)12-6-4-3-5-7-12/h3-9,11,16-17H,10H2,1-2H3,(H,20,23)
SMILES O=C1C2C(N=CN2C(CNC3=CC=C(C4=CC=CC=C4)N=N3)=O)N(C)C(N1C)=O
Form N/A
Color N/A
Solubility  Soluble in DMSO
Storage Temp.  0 – 4 C for short term (days to weeks), or -20 C for long term (months)
Shelf life > >2 years if stored properly
Handling N/A
Application N/A

 


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RIDADR NONH for all modes of transport

References:

[1]. Madan B, McDonald MJ, Foxa GE, Diegel CR, Williams BO, Virshup DM. Bone Res. 2018 May 25;6:17. doi: 10.1038/s41413-018-0017-8. eCollection 2018.

[2]. .Katoh M. Int J Oncol. 2017 Nov;51(5):1357-1369. doi: 10.3892/ijo.2017.4129. Epub 2017 Sep 19. Review.

[3]. Katoh M, Katoh M. Int J Mol Med. 2017 Sep;40(3):587-606. doi: 10.3892/ijmm.2017.3071. Epub 2017 Jul 19.

[4].Madan B, Ke Z, Lei ZD, Oliver FA, Oshima M, Lee MA, Rozen S, Virshup DM. Oncotarget. 2016 Mar 15;7(11):12386-92. doi: 10.18632/oncotarget.7157.

[5]. Madan B, Ke Z, Harmston N, Ho SY, Frois AO, Alam J, Jeyaraj DA, Pendharkar V, Ghosh K, Virshup IH, Manoharan V, Ong EH, Sangthongpitag K, Hill J, Petretto E, Keller TH, Lee MA, Matter A, Virshup DM. Oncogene. 2016 Apr 28;35(17):2197-207. doi: 10.1038/onc.2015.280. Epub 2015 Aug 10.

1 review for ETC-159 (1638250-96-0)

  1. Cofttek

    Never had such good experience before,The ETC-159 (1638250-96-0) is high purity,also customer service is pretty nice !gotta try!!

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