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GPCR&G protein

NIBR189 (1599432-08-2)

NIBR-189 is a potent and selective EBI2 (GPR183) receptor antagonist (IC50 values are 11 and 15 nM for human and mouse EBI2 receptors respectively).

Not Intended for Therapeutic Use. For research use only.

CAS: 1599432-08-2 Category

NIBR189 (1599432-08-2) Description

NIBR-189 Potent and selective EBI2 (GPR183) receptor antagonist (IC50 values are 11 and 15 nM for human and mouse EBI2 receptors respectively). Exhibits selectivity for EBI2 over a panel of other receptors, enzymes and transporters. Blocks oxysterol-induced migration of U937 monocyte cells. Orally bioavailable.

NIBR-189 is a potent and selective EBI2 (GPR183) receptor antagonist (IC50 values are 11 and 15 nM for human and mouse EBI2 receptors respectively). NIBR-189 blocks migration of a monocyte cell line called U937, suggesting a functional role of the oxysterol/EBI2 pathway in these immune cells.

NIBR189 (1599432-08-2) Specifications

Product Name NIBR-189
Synonyms NIBR-189; NIBR 189; NIBR189.
Chemical Names (E)-3-(4-bromophenyl)-1-(4-(4-methoxybenzoyl)piperazin-1-yl)prop-2-en-1-one
Purity ≥98% (HPLC)
CAS Number 1599432-08-2
Molecular Formula C21H21BrN2O3
Molecular Weight 429.314
Exact Mass 428.0736
MDL number  
InChIKey OFHXXBRBGWUOHR-NYYWCZLTSA-N
InChi Code InChI=1S/C21H21BrN2O3/c1-27-19-9-5-17(6-10-19)21(26)24-14-12-23(13-15-24)20(25)11-4-16-2-7-18(22)8-3-16/h2-11H,12-15H2,1H3/b11-4+
SMILES O=C(N1CCN(C(C2=CC=C(OC)C=C2)=O)CC1)/C=C/C3=CC=C(Br)C=C3
Form Powder
Color  
Solubility  in DMSO with gentle warming
Storage Temp.  Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years)
Shelf life >2 years if stored properly.
Handling Protect from air and light
Application  NIBR-189 is a potent and selective EBI2 (GPR183) receptor antagonist

 


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RIDADR NONH for all modes of transport

References:

1: Gessier F, Preuss I, Yin H, Rosenkilde MM, Laurent S, Endres R, Chen YA, Marsilje TH, Seuwen K, Nguyen DG, Sailer AW. Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor. J Med Chem. 2014 Apr 24;57(8):3358-68. doi: 10.1021/jm4019355. Epub 2014 Apr 15. PubMed PMID: 24678947.

1 review for NIBR189 (1599432-08-2)

  1. Rated 5 out of 5

    Cofttek

    Never had such good experience before,The NIBR189 (1599432-08-2) is high purity,also customer service is pretty nice !gotta try!!

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