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Gamma Secretase

ID8 (147591-46-6)

ID-8 is a DYRK inhibitor, and sustains embryonic stem cell self-renewal in long-term culture. ID-8 is a DYRK inhibitor. ID-8 could support Wnt-induced human embryonic stem cell proliferation and survival without differentiation.

Not Intended for Therapeutic Use. For research use only.

CAS: 147591-46-6 Category

ID8 (147591-46-6) Description:

ID-8 is a DYRK inhibitor. ID-8 could support Wnt-induced human embryonic stem cell proliferation and survival without differentiation. Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) is the target of the small molecule ID-8. Its role in human pluripotent cell renewal was confirmed by DYRK knockdown in human embryonic stem cells. ID-8 reversibly maintains the long-term culture of ESCs by sustaining Nanog gene expression through Sox2-Oct3/4 activation. ID-8 enhances Wnt-mediated hESC survival and proliferation via inhibition of DYRKs. The mechanism study indicates that ID-8 maintains the undifferentiated state in the presence of Wnt by modulating Wnt/β-catenin signaling and enhancing the CBP/β-catenin association in hESCs. For the detailed information of ID-8, the solubility of ID-8 in water, the solubility of ID-8 in DMSO, the solubility of ID-8 in PBS buffer, the animal experiment (test) of ID-8, the cell expriment (test) of ID-8, the in vivo, in vitro and clinical trial test of ID-8, the EC50, IC50,and Affinity of ID-8, Please contact DC Chemicals.

ID8 (147591-46-6) Specifications:

Product Name ID-8
Synonyms ID-8; ID 8; ID8.
Chemical Names 1-(4-methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol
Purity >98% (or refer to the Certificate of Analysis)
CAS Number 147591-46-6
Molecular Formula C16H14N2O4
Molecular Weight 298.298
Monoisotopic Mass 241.11 g/mol
MDL number MFCD00593367
InChIKey VVZNWYXIOADGSW-UHFFFAOYSA-N
InChi Code InChI=1S/C16H14N2O4/c1-10-16(18(20)21)14-8-5-12(19)9-15(14)17(10)11-3-6-13(22-2)7-4-11/h3-9,19H,1-2H3
SMILES OC1=CC2=C(C=C1)C([N+]([O-])=O)=C(C)N2C3=CC=C(OC)C=C3
Form Powder
Color Yellow
Solubility  Soluble in DMSO, not in water
Storage Temp.  Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shelf life >2 years if stored properly.
Handling Protect from air and light
Application ID-8 is a DYRK inhibitor, and sustains embryonic stem cell self-renewal in long-term culture.

 


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RIDADR NONH for all modes of transport

References:

  • 1: Sylvain V, Lafarge S, Bignon YJ. Molecular pathways involved in response to ionizing radiation of ID-8 mouse ovarian cancer cells expressing exogenous full-length Brca1 or truncated Brca1 mutant. Int J Oncol. 2001 Sep;19(3):599-607. PubMed PMID: 11494042.
  • 2: Hasegawa K, Yasuda SY, Teo JL, Nguyen C, McMillan M, Hsieh CL, Suemori H, Nakatsuji N, Yamamoto M, Miyabayashi T, Lutzko C, Pera MF, Kahn M. Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion. Stem Cells Transl Med. 2012 Jan;1(1):18-28. doi: 10.5966/sctm.2011-0033. PubMed PMID: 23197636; PubMed Central PMCID: PMC3727690.
  • 3: Su F, Kozak KR, Imaizumi S, Gao F, Amneus MW, Grijalva V, Ng C, Wagner A, Hough G, Farias-Eisner G, Anantharamaiah GM, Van Lenten BJ, Navab M, Fogelman AM, Reddy ST, Farias-Eisner R. Apolipoprotein A-I (apoA-I) and apoA-I mimetic peptides inhibit tumor development in a mouse model of ovarian cancer. Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19997-20002. doi: 10.1073/pnas.1009010107. PubMed PMID: 21041624; PubMed Central PMCID: PMC2993420.
  • 4: Uchiyama A, Chang C, Suzuki S, Mashimo T, Fujino Y. An expiratory assist during spontaneous breathing can compensate for endotracheal tube resistance. Anesth Analg. 2009 Aug;109(2):434-40. doi: 10.1213/ane.0b013e3181aa5cdb. PubMed PMID: 19608814.
  • 5: Sylvain V, Lafarge S, Bignon YJ. Dominant-negative activity of a Brca1 truncation mutant: effects on proliferation, tumorigenicity in vivo, and chemosensitivity in a mouse ovarian cancer cell line. Int J Oncol. 2002 Apr;20(4):845-53. PubMed PMID: 11894135.

1 review for ID8 (147591-46-6)

  1. Rated 5 out of 5

    Cofttek

    Never had such good experience before,The ID8 (147591-46-6) is high purity,also customer service is pretty nice !gotta try!!

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