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PDGFR&FGFR

AC710 (1351522-04-7)

AC710 is a potent, orally active, and selective platelet-derived growth factor receptor-family kinase inhibitor with potential anticancer activity..

Not Intended for Therapeutic Use. For research use only.

CAS: 1351522-04-7 Category

AC710 (1351522-04-7) Description:

AC710 is a potent, orally active, and selective platelet-derived growth factor receptor-family kinase inhibitor with potential anticancer activity. Its IC50 values are 1.2, 2, 7.7 and 10.5 nM for KIT, FLT3, PDGFRβ and CSF1R respectively; Kd = 1.3 nM for PDGFRα.. AC710 causes tumor regression of leukemia cell xenografts in mice. AC710 also reduces joint swelling and inflammation in a mouse model of collagen-induced arthritis. AC710 is now a preclinical development candidate.

AC710 (1351522-04-7) Specifications:

Product Name AC710
Synonym AC710; AC 710; AC-710.
Chemical Name N-(4-(3-(5-(tert-butyl)isoxazol-3-yl)ureido)phenyl)-5-((1-ethyl-2,2,6,6-tetramethylpiperidin-4-yl)oxy)picolinamide
Purity ≥98% (HPLC)
CAS Number 1351522-04-7
Molecular Formula C31H42N6O4
Molecular Weight 562.715 g/mol
Monoisotopic Mass 562.327 g/mol
MDL number N/A
InChIKey JVCWPUFNLFSKFS-UHFFFAOYSA-N
InChi Code InChI=1S/C31H42N6O4/c1-9-37-30(5,6)17-23(18-31(37,7)8)40-22-14-15-24(32-19-22)27(38)33-20-10-12-21(13-11-20)34-28(39)35-26-16-25(41-36-26)29(2,3)4/h10-16,19,23H,9,17-18H2,1-8H3,(H,33,38)(H2,34,35,36,39)
SMILES O=C(NC1=CC=C(NC(NC2=NOC(C(C)(C)C)=C2)=O)C=C1)C3=NC=C(OC4CC(C)(C)N(CC)C(C)(C)C4)C=C3
Form Powder
Color N/A
Solubility  DMSO
Storage Temp.  -20°C
Shelf life >2 years if stored properly
Handling Protect from air and moisture
Application potent, orally active, and selective platelet-derived growth factor receptor-family kinase inhibitor

 


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RIDADR NONH for all modes of transport

References:

[1]. Liu *†, Brian T. Campbell †, Mark W. Holladay †, Julia M. Ford Pulido ‡, Helen Hua ‡, Dana Gitnick , Michael F. Gardner , Joyce James , Mike A. Breider , Daniel Brigham ‡, Barbara Belli ‡, Robert C. Armstrong ‡, and Daniel K. Treiber. Discovery of AC710, a Globally Selective Inhibitor of Platelet-Derived Growth Factor Receptor-Family Kinases. ACS Med. Chem. Lett., 2012, 3 (12), pp 997–1002

1 review for AC710 (1351522-04-7)

  1. Rated 5 out of 5

    Cofttek

    Never had such good experience before,The AC710 (1351522-04-7) is high purity,also customer service is pretty nice !gotta try!!

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