RKI-1447 (1342278-01-6) Description:
RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer. RKI-1447 is a Type I kinase inhibitor that binds the ATP binding site through interactions with the hinge region and the DFG motif. RKI-1447 suppressed phosphorylation of the ROCK substrates MLC-2 and MYPT-1 in human cancer cells.
RKI-1447 binds the ATP binding site through interactions with the hinge region and the DFG motif. RKI-1447 suppresses phosphorylation of the ROCK substrates mLC-2 and MYPT-1 in human cancer cells, but has no effect on the phosphorylation levels of the AKT, MEK and S6 kinase at concentrations as high as 10 μM. RKI-1447 is also highly selective at inhibiting ROCK-mediated cytoskeleton re-organization. RKI-1447 inhibits migration, invasion and anchorage-independent tumor growth of breast cancer cells.
RKI-1447 (1342278-01-6) Specifications:
|Synonym||RKI-1447; RKI1447; RKI 1447. ROCK Inhibitor XIII.|
|Monoisotopic Mass||326.08375 g/mol|
|Solubility||Soluble in DMSO, not in water|
|Shelf life||>2 years if stored properly|
|Handling||Protect from air and light|
|Application||A potent inhibitor of the Rho-associated ROCK kinases|