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S6 kinase&PKD-1

kb NB 142-70 (1233533-04-4)

kb NB 142-70 is a selective protein kinase D (PKD) inhibitor (IC50 values are 28.3, 58.7 and 53.2 nM for PKD1, 2 and 3 respectively).-PKD inhibitor.

Not Intended for Therapeutic Use. For research use only.

CAS: 1233533-04-4 Category

kb NB 142-70 (1233533-04-4) Description

kb NB 142-70 is a selective protein kinase D (PKD) inhibitor (IC50 values are 28.3, 58.7 and 53.2 nM for PKD1, 2 and 3 respectively).kb NB 142-70 is a selective protein kinase D (PKD) inhibitor with IC50 values are 28.3, 58.7 and 53.2 nM for PKD1, 2 and 3 respectively. kb NB 142-70 prevents wound-induced migration of intestinal epithelial cells. PKD1, the most studied member of the PKD family, is implicated in the regulation of a remarkable array of fundamental biological processes, including signal transduction, cell proliferation and differentiation, membrane trafficking, hormone secretion, immune regulation, cardiac hypertrophy, angiogenesis, and cancer.

kb NB 142-70 (1233533-04-4) Specifications

Product Name kb NB 142-70
Synonym kb NB 142-70; kb NB142-70; kb NB-142-70.
Chemical Name 9-hydroxy-3,4-dihydrobenzo[4,5]thieno[2,3-f][1,4]thiazepin-5(2H)-one
Drug Class PKD inhibitor
Purity ≥98% (HPLC)
CAS Number 1233533-04-4
Molecular Formula C11H9NO2S2
Molecular Weight 251.00747
Monoisotopic Mass 251.32 g/mol
MDL number  MFCD18086915
InChIKey DHUAGGSHTKPOHU-UHFFFAOYSA-N
InChi Code InChI=1S/C11H9NO2S2/c13-6-1-2-8-7(5-6)9-10(16-8)11(14)12-3-4-15-9/h1-2,5,13H,3-4H2,(H,12,14)
SMILES O=C1NCCSC2=C1SC3=CC=C(O)C=C32
Form Powder
Color N/A
Solubility  Soluble in DMSO, not in water
Storage Temp.  0 – 4 C for short term (days to weeks), or -20 C for long term (months).
Shelf life >2 years if stored properly
Handling Protect from air and moisture
Application A selective PKD inhibitor

 


RIDADR NONH for all modes of transport

References:

[1]. Young SH, Rozengurt N, Sinnett-Smith J, Rozengurt E. Rapid protein kinase D1 signaling promotes migration of intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2012 Aug 1;303(3):G356-66. doi: 10.1152/ajpgi.00025.2012. Epub 2012 May 17. PubMed PMID: 22595992; PubMed Central PMCID: PMC3423107.

[2]. Yang, Chun; Ren, Qian; Qu, Youge; Zhang, Ji-Chun; Ma, Min; Dong, Chao; Hashimoto, Kenji – Biological Psychiatry 2018 vol. 83 # 1 p. 18 – 28

[1]. Kawata, Takahito; Tada, Kohei; Kobayashi, Masayuki; Sakamoto, Takashi; Takiuchi, Yoko; Iwai, Fumie; Sakurada, Maki;Sato, Hironori; Takaori-Kondo, Akifumi – Cancer Science 2018 vol. 109 # 1 p. 103 – 111

[4]. Ni Y, Wang L, Zhang J, Pang Z, Liu Q, Du J. PKD1 is downregulated in non-small cell lung cancer and mediates the feedback inhibition of mTORC1-S6K1 axis in response to phorbol ester. Int J Biochem Cell Biol. 2015 Mar;60:34-42. doi: 10.1016/j.biocel.2014.12.018. Epub 2015 Jan 9. PubMed PMID: 25578563.

[5]. Li, Dong-Dong; Meng, Xiang-Feng; Wang, Qiang; Yu, Pan; Zhao, Lin-Guo; Zhang, Zheng-Ping; Wang, Zhen-Zhong; Xiao, Wei – Journal of Molecular Graphics and Modelling 2018 vol. 79 p. 81 – 87