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Akt &GSK-3

Torin 1 (1222998-36-8)

Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM; exhibits 1000-fold selectivity for mTOR than PI3K.

Not Intended for Therapeutic Use. For research use only.

CAS: 1222998-36-8 Category

Torin 1 (1222998-36-8) Description

Torin-1 is a potent and selective mTOR inhibitor. The apoptosis-inducing mTOR inhibitor Torin-1 hindered growth, motility, invasion, and survival of CoCSCs in vitro, and suppressed tumor growth in vivo with a concomitant reduction in vessel formation. Torin-1 also affected the expression of markers for cell proliferation, angio-/lympho-genesis, and stemness in vivo, including Ki67, DLL1, DLL4, Notch, Lgr5, and CD44. Importantly, Torin-1 did not affect the survival of normal colon stem cells in vivo, suggesting its selectivity towards cancer cells.

Torin 1 (1222998-36-8) Specifications

Product Name Torin 1
Synonym Torin-1; Torin1; Torin 1.
Chemical Name 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one
Drug Class Antineoplastics
Purity ≥98% (HPLC)
CAS Number 1222998-36-8
Molecular Formula C35H28F3N5O2
Molecular Weight 607.6372
Monoisotopic Mass 607.2195 g/mol
MDL number N/A
InChIKey AKCRNFFTGXBONI-UHFFFAOYSA-N
InChi Code InChI=1S/C35H28F3N5O2/c1-2-32(44)42-15-13-41(14-16-42)31-11-9-26(19-28(31)35(36,37)38)43-33(45)12-8-24-20-40-30-10-7-22(18-27(30)34(24)43)25-17-23-5-3-4-6-29(23)39-21-25/h3-12,17-21H,2,13-16H2,1H3
SMILES O=C1N(C2=CC=C(N3CCN(C(CC)=O)CC3)C(C(F)(F)F)=C2)C4=C(C=NC5=CC=C(C6=CC7=CC=CC=C7N=C6)C=C54)C=C1
Form Powder
Color White
Solubility  Soluble in DMSO, not soluble in water
Storage Temp.  0 – 4 C for short term (days to weeks), or -20 C for long term (months)
Shelf life >2 years if stored properly
Handling Protect from air and moisture
Application Torin-1 is a potent and selective mTOR inhibitor

 


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RIDADR NONH for all modes of transport

References:

[1]. Impact on Autophagy and Ultraviolet B Induced Responses of Treatment with the MTOR Inhibitors Rapamycin, Everolimus, Torin 1, and pp242 in Human Keratinocytes.

Xu S et al. Oxid Med Cell Longev. (2017)

[2]. Two mTOR inhibitors, rapamycin and Torin 1, differentially regulate iron-induced generation of mitochondrial ROS.

Huang H et al. Biometals. (2017)

[3]. Intra-articular injection of Torin 1 reduces degeneration of articular cartilage in a rabbit osteoarthritis model.

Cheng NT et al. Bone Joint Res. (2016)

[4]. Impact on Autophagy and Ultraviolet B Induced Responses of Treatment with the MTOR Inhibitors Rapamycin, Everolimus, Torin 1, and pp242 in Human Keratinocytes.

Xu S, Li L, Li M, Zhang M, Ju M, Chen X, Gu H.

Oxid Med Cell Longev. 2017;2017:5930639. doi: 10.1155/2017/5930639. Epub 2017 Mar 16.

PMID: 28400912

[5].Two mTOR inhibitors, rapamycin and Torin 1, differentially regulate iron-induced generation of mitochondrial ROS.

Huang H, Chen J, Lu H, Zhou M, Chai Z, Hu Y.

Biometals. 2017 Dec;30(6):975-980. doi: 10.1007/s10534-017-0059-1. Epub 2017 Oct 23.

PMID: 29063293

1 review for Torin 1 (1222998-36-8)

  1. Cofttek

    Never had such good experience before,The Torin 1 (1222998-36-8) is high purity,also customer service is pretty nice !gotta try!!

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