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TGF-beta&Smad

DMH1 (1206711-16-1)

DMH1 is a selective BMP receptor inhibitor with IC50 of 107.9 nM for ALK2, exhibiting no inhibition on AMPK, ALK5, KDR (VEGFR-2) or PDGFR.

Not Intended for Therapeutic Use. For research use only.

CAS: 1206711-16-1 Category

DMH1 (1206711-16-1) Description:

DMH-1 is a selective inhibitor of ACTR-I, the bone morphogenic protein (BMP) ALK2 receptor. This compound has an IC50 = 108 nM and displayes no detectable inhibition of AMPK, ALK5, KDR (VEGFR-2) or PDGFRβ receptors. DMH-1 blocks phosphorylation of Smads 1, 5, and 8 in HEK293 cells induced by BMP4.

Bone morphogenetic proteins (BMP) are secreted signaling proteins, many of which are involved in various developmental processes, in addition to bone formation.DMH1 is an analog of the non-selective BMP receptor inhibitor dorsomorphin that potently inhibits the kinase activity of activin receptor-like kinase 2 (ALK2; IC50 = 13-108 nM).It is much less effective at ALK4, ALK5, AMPK, KDR (VEGFR2) or PDGFRβ, although it inhibits ALK1 and ALK3 at nanomolar concentrations.DMH1 is effective in vivo, as it disrupts dorsoventral development in zebrafish.It also affects stem cell development, increasing cardiomyocyte progenitors and promoting neurogenesis. DMH1 inhibits the growth of lung cancer cells, reducing tumor growth in a xenograft mouse model.

DMH1 (1206711-16-1) Specifications:

Product Name DMH1
Synonyms DMH 1; DMH-1; BMP Inhibitor II

DorsoMorphin Homolog 1

VU036482

 

Chemical Name 4-[6-(4-propan-2-yloxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
Purity >98%
CAS Number 1206711-16-1
Molecular Formula C24H20N4O
Molecular Weight 380.451 g/mol
Monoisotopic Mass 380.164 g/mol
MDL number MFCD18384963
InChIKey JMIFGARJSWXZSH-UHFFFAOYSA-N
InChi Code InChI=1S/C24H20N4O/c1-16(2)29-19-9-7-17(8-10-19)18-13-26-24-22(14-27-28(24)15-18)20-11-12-25-23-6-4-3-5-21(20)23/h3-16H,1-2H3
SMILES CC(C)OC1=CC=C(C=C1)C2=CN3C(=C(C=N3)C4=CC=NC5=CC=CC=C45)N=C2
Form powder
Color light yellow to orange
Solubility  Soluble in DMSO
Storage Temp.  0 – 4 C for short term (days to weeks), or -20 C for long term (months).
Shelf life >2 years if stored properly
Handling Protect from air and light
Application A selective inhibitor of the bone morphogenic protein (BMP) ALK2 receptor; ALK2 inhibitor

 


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RIDADR NONH for all modes of transport

References:

  • DMH1 (4-[6-(4-isopropoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline) inhibits chemotherapeutic drug-induced autophagy. Sheng Y et al. Acta Pharm Sin B. (2015)
  • DMH1 increases glucose metabolism through activating Akt in L6 rat skeletal muscle cells. Xie X et al. PLoS One. (2014)
  • DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction. Neely MD et al. ACS Chem Neurosci. (2012)

1 review for DMH1 (1206711-16-1)

  1. Cofttek

    Never had such good experience before,The DMH1 (1206711-16-1) is high purity,also customer service is pretty nice !gotta try!!

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