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S6 kinase&PKD-1

PS48 (1180676-32-7)

PS-48 is a phosphoinositide-dependent protein kinase-1 (PDK1) activator. PDK1 PS48 is a small molecule agonists and Kd value is 10.3uM, the specificity of PDK1 PIF-binding of pocket, different from the ATP binding site.

Not Intended for Therapeutic Use. For research use only.

CAS: 1180676-32-7 Category

PS48 (1180676-32-7) Description

PS48 is PDK1 (phosphoinositide-dependent protein kinase 1) activator .PS48 is a PDK1 (phosphoinositide-dependent protein kinase 1) activator which binds to the HM/PIF binding pocket rather than the ATP-binding site. PS48 is one of only a few truly allosteric compounds targeting a regulatory binding site on a protein kinase catalytic domain that is not adjacent to or overlapping with the ATP-binding site.

PS48 (1180676-32-7) Specifications

Product Name PS48
Synonym PS-48; PS 48; PS48;
Chemical Name (2Z)-5-(4-Chlorophenyl)-3-phenyl-2-pentenoic acid
Drug Class PDK1 (phosphoinositide-dependent protein kinase 1) activator
Purity ≥98% (HPLC)
CAS Number 1180676-32-7
Molecular Formula C17H15ClO2
Molecular Weight 286.75
Monoisotopic Mass 286.07 g/mol
MDL number MFCD17215962
InChIKey LLJYFDRQFPQGNY-QINSGFPZSA-N
InChi Code InChI=1S/C17H15ClO2/c18-16-10-7-13(8-11-16)6-9-15(12-17(19)20)14-4-2-1-3-5-14/h1-5,7-8,10-12H,6,9H2,(H,19,20)/b15-12-
SMILES O=C(O)/C=C(C1=CC=CC=C1)/CCC2=CC=C(Cl)C=C2
Form Powder
Color white to off-white
Solubility  Soluble in DMSO
Storage Temp.  Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shelf life >2 years if stored properly
Handling Protect from air and moisture
Application A phosphoinositide-dependent protein kinase-1 (PDK1) activator

 


RIDADR NONH for all modes of transport

References:

[1]. Han F, Xue M, Chang Y, Li X, Yang Y, Sun B, Chen L. Triptolide Suppresses Glomerular Mesangial Cell Proliferation in Diabetic Nephropathy Is Associated with Inhibition of PDK1/Akt/mTOR Pathway. Int J Biol Sci. 2017 Sep 21;13(10):1266-1275. doi: 10.7150/ijbs.20485. eCollection 2017. PubMed PMID: 29104493; PubMed Central PMCID: PMC5666525.

[2]. Liu Z, Ren J, Cao J, He J, Yao X, Jin C, Xue Y. Systematic analysis of the Plk-mediated phosphoregulation in eukaryotes. Brief Bioinform. 2013 May;14(3):344-60. doi: 10.1093/bib/bbs041. Epub 2012 Jul 31. Review. PubMed PMID: 22851512.

[3]. Linli Wang et. AlStem cell research & therapy, 8(1), undefined (2017-11-4)

[4]. Tohru Kimura et. Al Stem cells (Dayton, Ohio), 32(10), undefined (2014-7-6)

[5]. Shun Watanabe et. Al Pflugers Archiv : European journal of physiology, 468(4), undefined (2015-11-19)