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MEK&P38 MAPK

U0126-EtOH (1173097-76-1)

U0126-EtOH(U-0126) is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD098059.

Not Intended for Therapeutic Use. For research use only.

CAS: 1173097-76-1 Category

U0126-EtOH (1173097-76-1) Description:

U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD98059. This inhibition of MEK1/2 is noncompetitive with ERK and ATP.

U0126.EtOH is an addition compound obtained by combining equimolar amounts of (2Z,3Z)-bis{amino[(2-aminophenyl)sulfanyl]methylidene}butanedinitrile (U0126) and ethanol. An inhibitor of mitogen-activated protein kinase that also exhibits anti-cancer properties. It has a role as an EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor, an apoptosis inducer, an antineoplastic agent, an antioxidant, an osteogenesis regulator and a vasoconstrictor agent. It contains an U0126.

U0126-EtOH (1173097-76-1) Specifications:

Product Name U0126-EtOH
Synonym U0126-EtOH; U0126EtOH; U0126 EtOH, U0126, U-0126, U 0126
Chemical Name (2Z,3Z)-2,3-bis(amino((2-aminophenyl)thio)methylene)succinonitrile compound with ethanol (1:1)
Drug Class N/A
Purity >98% (or refer to the Certificate of Analysis)
CAS Number 1173097-76-1
Molecular Formula C20H22N6OS2
Molecular Weight 426.56
Monoisotopic Mass
426.13 g/mol

 

MDL number MFCD25977152
InChIKey CFQULUVMLGZVAF-OYJDLGDISA-N
InChi Code InChI=1S/C18H16N6S2.C2H6O/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22;1-2-3/h1-8H,21-24H2;3H,2H2,1H3/b17-11+,18-12+;
SMILES CCO.C1=CC=C(C(=C1)N)SC(=C(C#N)C(=C(N)SC2=CC=CC=C2N)C#N)N
Form solid powder
Color White to off-white
Solubility  Soluble in DMSO, not soluble in water.
Storage Temp.  Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shelf life >2 years if stored properly
Handling Protect from air and moisture
Application antineoplastic agent:

A substance that inhibits or prevents the proliferation of neoplasms.

vasoconstrictor agent:

Drug used to cause constriction of the blood vessels.

 


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RIDADR NONH for all modes of transport

References:

  • 1. Satoh T, Nakatsuka D, Watanabe Y, et al. Neuroprotection by MAPK/ERK kinase inhibition with U0126 against oxidative stress in a mouse neuronal cell line and rat primary cultured cortical neurons. Neuroscience letters, 2000, 288(2): 163-166.
  • 2. Sonic Hedgehog Signaling Pathway Mediates Proliferation and Migration of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis via MAPK/ERK Signaling Pathway. Liu F, Feng XX, Zhu SL, Huang HY, Chen YD, Pan YF, June RR, Zheng SG, Huang JL. Front Immunol. 2018 Dec 5;9:2847. doi: 10.3389/fimmu.2018.02847. eCollection 2018.
  • 3.Identification of Functional MKK3/6 and MEK1/2 Homologs from Echinococcus granulosus and Investigation of Protoscolecidal Activity of Mitogen-Activated Protein Kinase Signaling Pathway Inhibitors In Vitro and In Vivo. Zhang C, Li J, Aji T, Li L, Bi X, Yang N, Li Z, Wang H, Mao R, Lü G, Shao Y, Vuitton DA, Wen H, Lin R. Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01043-18. doi: 10.1128/AAC.01043-18. Print 2019 Jan.
  • 4.[Effect of Picroside II on ERK1/2 Signal Pathway in Cerebral lschemic Injury Rats]. Wang TT, Zhai L, Zhang HY, Zhao L, Guo YL. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2016 Apr;36(4):437-44. Chinese.
  • 5. Netrin-1 induces the migration of Schwann cells via p38 MAPK and PI3K-Akt signaling pathway mediated by the UNC5B receptor. Lv J, Sun X, Ma J, Ma X, Zhang Y, Li F, Li Y, Zhao Z. Biochem Biophys Res Commun. 2015 Aug 14;464(1):263-8. doi: 10.1016/j.bbrc.2015.06.140. Epub 2015 Jun 23.

1 review for U0126-EtOH (1173097-76-1)

  1. Cofttek

    Never had such good experience before,The U0126-EtOH (1173097-76-1) is high purity,also customer service is pretty nice !gotta try!!

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