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GPCR&G protein

VU0361737 (1161205-04-4)

VU 0361737 is a selective positive allosteric modulator at mGluR-4 (EC50 values are 240 and 110 nM at human and rat receptors respectively)…

Not Intended for Therapeutic Use. For research use only.

CAS: 1161205-04-4 Category

VU0361737 (1161205-04-4) Description

VU 0361737 is a selective positive allosteric modulator (PAM) for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and rat receptors, respectively, displays weak activity at mGlu5 and mGlu8 receptors, is inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors, can penetrate into CNS.

VU0361737 (1161205-04-4) Specifications

Product Name VU0361737
Synonyms VU 0361737, VU-0361737, VU0361737
Chemical Names  VU 0361737; 1161205-04-4; VU0361737; N-(4-chloro-3-methoxyphenyl)picolinamide; N-(4-CHLORO-3-METHOXYPHENYL)-2-PYRIDINECARBOXAMIDE; N-(4-chloro-3-methoxyphenyl)pyridine-2-carboxamide
Purity >98%
CAS Number 1161205-04-4
Molecular Formula C13H11ClN2O2
Molecular Weight 262.693 g/mol
Monoisotopic Mass 262.051 g/mol
InChIKey ARYUXFNGXHNNDM-UHFFFAOYSA-N
InChi Code InChI=1S/C13H11ClN2O2/c1-18-12-8-9(5-6-10(12)14)16-13(17)11-4-2-3-7-15-11/h2-8H,1H3,(H,16,17)
SMILES O=C(C1=NC=CC=C1)NC2=CC=C(Cl)C(OC)=C2
Form Powder
Color White
Solubility  Soluble in DMSO
Storage Temp.  −20°C
Shelf life >2 years if stored properly.
Handling Dry, dark
Application a selective positive allosteric modulator (PAM) for mGlu4 receptor

 


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RIDADR NONH for all modes of transport

References:

  •  1: Lindqvist D, Dhabhar FS, James SJ, Hough CM, Jain FA, Bersani FS, Reus VI, Verhoeven JE, Epel ES, Mahan L, Rosser R, Wolkowitz OM, Mellon SH. Oxidative stress, inflammation and treatment response in major depression. Psychoneuroendocrinology. 2016 Nov 30;76:197-205. doi: 10.1016/j.psyneuen.2016.11.031. [Epub ahead of print] PubMed PMID: 27960139.
  • 2: Lusli M, Peters R, van Brakel W, Zweekhorst M, Iancu S, Bunders J, Irwanto, Regeer B. The Impact of a Rights-Based Counselling Intervention to Reduce Stigma in People Affected by Leprosy in Indonesia. PLoS Negl Trop Dis. 2016 Dec 13;10(12):e0005088. doi: 10.1371/journal.pntd.0005088. PubMed PMID: 27959932.
  • 3: Zhang L, Chen XL, Hu Q, Chen K, Yan X, Li SP, Freilich S, Jiang JD. Haoranjiania flava gen. nov., sp. nov., a new member of the family Chitinophagaceae, isolated from activated sludge. Int J Syst Evol Microbiol. 2016 Nov;66(11):4686-4691. doi: 10.1099/ijsem.0.001411. PubMed PMID: 27958192.
  • 4: Verwer EE, Zegers CM, van Elmpt W, Wierts R, Windhorst AD, Mottaghy FM, Lambin P, Boellaard R. Pharmacokinetic modeling of a novel hypoxia PET tracer [(18)F]HX4 in patients with non-small cell lung cancer. EJNMMI Phys. 2016 Dec;3(1):30. PubMed PMID: 27957730.
  • 5: Zinsmeister J, Lalanne D, Terrasson E, Chatelain E, Vandecasteele C, Vu BL, Dubois-Laurent C, Geoffriau E, Signor CL, Dalmais M, Gutbrod K, Dörmann P, Gallardo K, Bendahmane A, Buitink J, Leprince O. ABI5 Is a Regulator of Seed Maturation and Longevity in Legumes. Plant Cell. 2016 Nov;28(11):2735-2754. PubMed PMID: 27956585.
  • 6: de Jong TD, Blits M, de Ridder S, Vosslamber S, Wolbink G, Nurmohamed MT, Verweij CL. Type I interferon response gene expression in established rheumatoid arthritis is not associated with clinical parameters. Arthritis Res Ther. 2016 Dec 12;18(1):290. PubMed PMID: 27955694.
  • 7: Tokuhara M, Gouda Y, Saito Y, Shimzu T, Minowada S, Sasajima K, Takeda Y, Thao LB, Vu HA, Sato Y. Gastrointestinal stromal tumor (GIST) that showed double new malignancies during imatinib therapy: A case report. J Clin Oncol. 2008 May 20;26(15_suppl):21517. PubMed PMID: 27951383.

1 review for VU0361737 (1161205-04-4)

  1. Rated 5 out of 5

    Cofttek

    Never had such good experience before,The VU0361737 (1161205-04-4) is high purity,also customer service is pretty nice !gotta try!!

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