Cofttek holdings limited

Wnt&Beta catenin

WAY-262611 (1123231-07-1)

WAY-262611 is a wingless β-Catenin agonist that increases bone formation rate; with EC50 of 0.63 uM in TCF-Luciferase assay.

Not Intended for Therapeutic Use. For research use only.

CAS: 1123231-07-1 Category

WAY-262611 (1123231-07-1) Description

WAY262611 HCl is a Wnt pathway agonist acting via inhibition of Dkk1 with no GSK-3. Inhibitor of Dickkopf-1 (DKK1); WAY 262611 is a wingless Wnt/β-Catenin signaling agonist with an inhibitory effect on DKK1, displaying an EC50 value of 0.63 μM for DKK1-mediated TCF-Luciferase, no affinity for GSK-3β (IC50 value >100 μM) and enhancing the bone formation rate in ovariectomized (OVX) rats following oral adminstration. Dickkopf-1 (DKK1) is a soluble inhibitor of Wnt-3a mediated Wnt/β-catenin signaling required for embryonic head development. It regulates Wnt signaling by binding to the Wnt coreceptor lipoprotein-related protein-5 (LRP5)/Arrow, and Kremen2 (Kr2) simultaneously.

 

WAY-262611 (1123231-07-1) Specifications

Product Name WAY-262611
Synonyms DKK1;MAY-262611;WAY-262611;Wnt/β-catenin;1-[4-(2-Naphthalenyl)-2-pyrimidinyl]-4-piperidinemethanamine;1-{1-[4-(2-Naphthyl)-2-pyrimidinyl]-4-piperidinyl}methanamine;4-PiperidineMethanaMine, 1-[4-(2-naphthalenyl)-2-pyriMidinyl]-;1-[4-(2-Naphthalenyl)-2-pyrimidinyl]-4-piperidinemethanamine MAY-262611
Chemical Names [1-(4-naphthalen-2-ylpyrimidin-2-yl)piperidin-4-yl]methanamine
Purity >98% (or refer to the Certificate of Analysis)
CAS Number 1123231-07-1
Molecular Formula C20H22N4
Molecular Weight 318.42
Monoisotopic Mass 318.184 g/mol
MDL number MFCD20527803
InChIKey QHLITPHIARVDJI-UHFFFAOYSA-N
InChi Code InChI=1S/C20H22N4/c21-14-15-8-11-24(12-9-15)20-22-10-7-19(23-20)18-6-5-16-3-1-2-4-17(16)13-18/h1-7,10,13,15H,8-9,11-12,14,21H2
SMILES C1CN(CCC1CN)C2=NC=CC(=N2)C3=CC4=CC=CC=C4C=C3
Form Powder
Color N/A
Solubility  ≥8.95mg/mL in DMSO
Storage Temp.  Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shelf life >2 years if stored properly
Handling Protect from air and light
Application WAY-262611 is a wingless beta-Catenin agonist that increases bone formation rate.

 


=

RIDADR NONH for all modes of transport

References:

  • Polakis P. Wnt signaling and cancer. Genes Dev. 2000 Aug 1;14(15):1837-51. Review. PubMed PMID: 10921899.
  • C. Pelletier et al. (1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine: a wingless beta-catenin agonist that increases bone formation rate. J. Med. Chem. 2009, 52, 6962-6965.
  • J. Pinzone et al. The role of Dickkopf-1 in bone development, homeostasis, and disease. Blood 2009, 113, 517-525.
  • Pelletier JC, et al. (1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine: a wingless beta-catenin agonist that increases bone formation rate. J Med Chem. 2009 Nov 26;52(22):6962-5.
  • Saikosaponin A Protects From Pressure Overload-Induced Cardiac Fibrosis via Inhibiting Fibroblast Activation or Endothelial Cell EndMT. Liu Y, Gao L, Zhao X, Guo S, Liu Y, Li R, Liang C, Li L, Dong J, Li L, Yang H. Int J Biol Sci. 2018 Oct 31;14(13):1923-1934. doi: 10.7150/ijbs.27022. eCollection 2018.