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PDGFR&FGFR

EMD1214063 (1100598-32-0)

EMD1214063 is an inhibitor of MET tyrosine kinase with potential antineoplastic activity. MET tyrosine kinase inhibitor EMD 1214063 selectively binds to MET tyrosine kinase and disrupts MET signal transduction pathways, which may induce apoptosis in tumor cells overexpressing this kinase…

Not Intended for Therapeutic Use. For research use only.

CAS: 1100598-32-0 Category

EMD1214063 (1100598-32-0) Description:

EMD1214063 also well known as Tepotinib. EMD1214063 is an inhibitor of MET tyrosine kinase with potential antineoplastic activity. EMD1214063(Tepotinib) selectively binds to MET tyrosine kinase and disrupts MET signal transduction pathways, which may induce apoptosis in tumor cells overexpressing this kinase. The receptor tyrosine kinase MET (also known as hepatocyte growth factor receptor or HGFR), is the product of the proto-oncogene c-Met and is overexpressed or mutated in many tumor cell types; this protein plays key roles in tumor cell proliferation, survival, invasion, and metastasis, and tumor angiogenesis.

EMD1214063 (1100598-32-0) Specifications:

Product Name EMD1214063
Synonym Tepotinib
Chemical Name EMD 1214063; MSC2156119; MSC2156119; MSC2156119

3-(1-(3-(5-((1-methylpiperidin-4-yl)methoxy)pyrimidin-2-yl)benzyl)-1,6-dihydro-6-oxopyridazin-3-yl)benzonitrile

Purity ≥98% (HPLC)
CAS Number  1100598-32-0
Molecular Formula C29H28N6O2
Molecular Weight 492.583 g/mol
Monoisotopic Mass 492.227 g/mol
MDL number N/A
InChIKey AHYMHWXQRWRBKT-UHFFFAOYSA-N
InChi Code InChI=1S/C29H28N6O2/c1-34-12-10-21(11-13-34)20-37-26-17-31-29(32-18-26)25-7-3-5-23(15-25)19-35-28(36)9-8-27(33-35)24-6-2-4-22(14-24)16-30/h2-9,14-15,17-18,21H,10-13,19-20H2,1H3
SMILES N#CC1=CC=CC(C(C=C2)=NN(CC3=CC=CC(C4=NC=C(OCC5CCN(C)CC5)C=N4)=C3)C2=O)=C1
Form Powder
Color N/A
Solubility  Soluble in DMSO, not in water
Storage Temp.  0 – 4 C for short term (days to weeks), or -20 C for long term (months)
Shelf life >2 years if stored properly
Handling Protect from air and moisture, dry, dark
Application inhibitor of MET tyrosine kinase

 


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RIDADR NONH for all modes of transport

References:

[1]. Bladt F, Faden B, Friese-Hamim M, Knuehl C, Wilm C, Fittschen C, Grädler U, Meyring M, Dorsch D, Jaehrling F, Pehl U, Stieber F, Schadt O, Blaukat A. EMD 1214063 and EMD 1204831 constitute a new class of potent and highly selective c-Met inhibitors. Clin Cancer Res. 2013 Jun 1;19(11):2941-51. doi: 10.1158/1078-0432.CCR-12-3247. Epub 2013 Apr 3. PubMed PMID: 23553846.

[2]. Scorsone K, Zhang L, Woodfield SE, Hicks J, Zage PE. Invest New Drugs. 2014 Oct;32(5):815-24. doi: 10.1007/s10637-014-0107-4. Epub 2014 May 16.PMID: 24832869

[3]. Medová M, Pochon B, Streit B, Blank-Liss W, Francica P, Stroka D, Keogh A, Aebersold DM, Blaukat A, Bladt F, Zimmer Y.Mol Cancer Ther. 2013 Nov;12(11):2415-24. doi: 10.1158/1535-7163.MCT-13-0151. Epub 2013 Sep 23.PMID: 24061647

[4]. Bladt F, Faden B, Friese-Hamim M, Knuehl C, Wilm C, Fittschen C, Grädler U, Meyring M, Dorsch D, Jaehrling F, Pehl U, Stieber F, Schadt O, Blaukat A.

Clin Cancer Res. 2013 Jun 1;19(11):2941-51. doi: 10.1158/1078-0432.CCR-12-3247. Epub 2013 Apr 3.PMID: 23553846

[5]. Bladt F, et al. Clin Cancer Res, 2013, 19(11), 2941-2951.

1 review for EMD1214063 (1100598-32-0)

  1. Rated 5 out of 5

    Cofttek

    Never had such good experience before,The EMD1214063 (1100598-32-0) is high purity,also customer service is pretty nice !gotta try!!

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