β-Nicotinamide Mononucleotide (1094-61-7) video
β-Nicotinamide Mononucleotide (NMN) Specifications
|Name:||β-Nicotinamide Mononucleotide (NMN)|
|Molecular Weight:||334.2208 g/mol|
|Chemical name:||((2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate|
|Synonyms:||Nicotinamide Mononucleotide; NMN; β-NMN; β-Nicotinamide mononucleotide|
|Solubility:||Soluble in DMSO, Methanol, Water|
|Storage Condition:||0 – 4 C for short term (days to weeks), or -20 C for long term (months)|
|Application:||Nicotinamide mononucleotide (NMN) is a derivative of the B-vitamin niacin that dramatically improves health and longevity by serving as a precursor to NAD+, a compound that plays a crucial role in energy production, metabolism, and gene expression in the body.|
What is β-Nicotinamide Mononucleotide (NMN) CAS 1094-61-7?
Nicotinamide Mononucleotide, also known as (“NMN” and “β-NMN”) is a nucleotide derived from ribose and nicotinamide Like nicotinamide riboside, NMN is a derivative of niacin, and humans have enzymes that can use NMN to generate nicotinamide adenine dinucleotide (NADH). Because NADH is a cofactor for processes inside mitochondria, for sirtuins, and for PARP, NMN has been studied in animal models as a potential neuroprotective and anti-aging agent.
β-Nicotinamide Mononucleotide (NMN) CAS 1094-61-7 benefits
Anti-aging research has shown that supplementation with NMN, a key NAD+ intermediate, is effective at mitigating age-associated metabolic decline and slowing the progression of a multitude of age-related diseases. NMN has beneficial effects on the production of energy at the cellular level, improves tolerance to glucose, reduces inflammation, helps preserve the circulatory system, repairs DNA, and has beneficial effects on the preservation of cognitive function. NMN has also shown potential as a therapeutic agent against neurodegenerative disorders typical of old age. Supplementation with NMN may be of benefit in preserving endurance and mobility. Preserving the functions of these diverse systems across the body promotes health and longevity and significantly improves quality of life as aging progresses.
β-Nicotinamide Mononucleotide (NMN) CAS 1094-61-7 Mechanism Of Action?
β-Nicotinamide Mononucleotide (NMN) is an intermediate of NAD+ biosynthesis produced from nicotinamide through nicotinamide phosphoribosyltransferase (NAMPT) and also referred to as NMN or nicotinamide ribotide. In recent studies of NMN applications to prevention and diagnosis of age-dependent diseases such as diabetes, neurodegenerative disorder, cardiac disease etc, it has become one of hottest biomarkers on discussion for anti-aging, lately.
β-Nicotinamide Mononucleotide (NMN) CAS 1094-61-7 Application
β-Nicotinamide Mononucleotide (NMN) has beneficial effects on metabolism throughout the body, including positive effects in skeletal muscle, liver function, bone density, eye function, insulin sensitivity, immune function, body weight, and activity levels.
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- Kiss T, Balasubramanian P, Valcarcel-Ares MN, Tarantini S, Yabluchanskiy A, Csipo T, Lipecz A, Reglodi D, Zhang XA, Bari F, Farkas E, Csiszar A, Ungvari Z. Nicotinamide mononucleotide (NMN) treatment attenuates oxidative stress and rescues angiogenic capacity in aged cerebromicrovascular endothelial cells: a potential mechanism for the prevention of vascular cognitive impairment. Geroscience. 2019 May 29. doi: 10.1007/s11357-019-00074-2. PubMed PMID: 31144244.
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- Grozio A, Mills KF, Yoshino J, Bruzzone S, Sociali G, Tokizane K, Lei HC, Cunningham R, Sasaki Y, Migaud ME, Imai SI. Slc12a8 is a nicotinamide mononucleotide transporter. Nat Metab. 2019 Jan;1(1):47-57. doi: 10.1038/s42255-018-0009-4. Epub 2019 Jan 7. PubMed PMID: 31131364; PubMed Central PMCID: PMC6530925.