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Wnt&Beta catenin

FH535 (108409-83-2)

FH535 is a Wnt/β-catenin signaling inhibitor and also a dual PPARγ and PPARδ antagonist.

Not Intended for Therapeutic Use. For research use only.

CAS: 108409-83-2 Category

FH535 (108409-83-2) Description

β-Catenin/Tcf Inhibitor, FH535 is a sulfonamide-based and cell-permeable compound that exhibits a dual pathway inhibition against Wnt/β-catenin and PPAR. FH535 and its structurally similar analog, PPAR inhibitor GW9662, both exhibit inhibition of coactivator/PPAR binding, though only FH535 blocks β-catenin/PPAR interaction. Further, the antagonistic activity of FH535 does not involve the covalent modification of non-covalent interaction with the PPR ligand-binding site cysteine residue, which has been experimentally shown to be crucial for GW9662 action. β-Catenin/Tcf Inhibitor, FH535 is an inhibitor of GRIP1, PPAR-β, and PPAR-γ.

 

FH535 (108409-83-2) Specifications

Product Name FH535
Synonyms FH535; FH 535; FH-535
Chemical Names 2,5-dichloro-N-(2-methyl-4-nitrophenyl)-benzenesulfonamide
Purity >98% (or refer to the Certificate of Analysis)
CAS Number 108409-83-2
Molecular Formula C13H10Cl2N2O4S
Molecular Weight 361.193
Monoisotopic Mass 359.974 g/mol
MDL number MFCD01212888
InChIKey AXNUEXXEQGQWPA-UHFFFAOYSA-N
InChi Code InChI=1S/C13H10Cl2N2O4S/c1-8-6-10(17(18)19)3-5-12(8)16-22(20,21)13-7-9(14)2-4-11(13)15/h2-7,16H,1H3
SMILES O=S(C1=CC(Cl)=CC=C1Cl)(NC2=CC=C([N+]([O-])=O)C=C2C)=O
Form Powder
Color Off-white
Solubility  Soluble in DMSO, not in water
Storage Temp.  Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shelf life >2 years if stored properly
Handling Protect from air and light
Application A cell-permeable compound that inhibits Wnt/β-catenin and PPAR

 


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