Fasudil hydrochloride (105628-07-7) Description
Fasudil, also known as HA-1077, is a potent Rho-kinase inhibitor and vasodilator. Since it was discovered, it has been used for the treatment of cerebral vasospasm, which is often due to subarachnoid hemorrhage, as well as to improve the cognitive decline seen in stroke victims. It has been found to be effective for the treatment of pulmonary hypertension. It was demonstrated in February 2009 that fasudil could also be used to enhance memory and improve the prognosis of Alzheimers patients. It is approved for use in Japan and China.
Studies suggest that when acting as a ROCK inhibitor, Fasudil reduces neutrophil transendothelial migration by diminishing cytoskeletal rearrangement of endothelial cells. In addition, Fasudil significantly protects against MeHg-induced axonal degeneration and apoptotic cell death in cultured cortical neurons. Alternate studies show that Fasudil plays an important role in osteoblastic differentiation of stromal cells via increasing the mRNA expression of collagen-I, osteocalcin, and bone morphogenetic protein-2 (BMP-2).
Fasudil hydrochloride (105628-07-7) Specifications
|Product Name||Fasudil hydrochloride|
|Synonym||HA-1077; HA1077; HA 1077; HA-1077 HCl; Fasudil hydrochloride.|
|Chemical Name||5-((1,4-diazepan-1-yl)sulfonyl)isoquinoline hydrochloride|
|Monoisotopic Mass||327.8 g/mol|
|Color||White to off-white|
|Solubility||Soluble in water (200 mg/mL), and DMSO (95 mg/mL). Insoluble in ethanol.|
|Shelf life||>2 years if stored properly|
|Handling||Protect from air and moisture|
|Application||A potent Rho-kinase inhibitor and vasodilator|