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PDGFR&FGFR

AMG208 (1002304-34-8)

AMG 208 is a small molecule inhibitor of c-Met which is a well-characterized receptor tyrosine kinase expressed on the surface of epithelial cells. C-Met receptor signaling has been shown to play a key role in the survival of cancer cells…

Not Intended for Therapeutic Use. For research use only.

CAS: 1002304-34-8 Category

AMG208 (1002304-34-8) Description:

AMG 208 is a small molecule inhibitor of c-Met which is a well-characterized receptor tyrosine kinase expressed on the surface of epithelial cells. C-Met receptor signaling has been shown to play a key role in the survival of cancer cells. AMG 208 inhibits both ligand-dependent and ligand-independent c‑Met cellular growth regulation. Inhibition of c-Met signaling with AMG 208 provides a potential mechanism for blocking tumor growth and survival. AMG-208 shows the potent inhibition of kinase c-Met activity with IC50 of 9 nM in a cell-free assay. Besides, AMG-208 treatment also leads to the inhibition of HGF-mediated c-Met phosphorylation in PC3 cells with IC50 of 46 nM.Incubation of AMG-208 with rat and human liver microsomes in the presence of NADPH qualitatively yields C6-phenylarene oxidation products as the major metabolites.

AMG208 (1002304-34-8) Specifications:

Product Name AMG208
Synonym AMG-208,AMG 208,
Chemical Name 7-Methoxy-4-[(6-phenyl-1,2,4-triazolo[4,3-b]pyridazin-3-yl)methoxy]quinoline
Purity ≥98% (HPLC)
CAS Number 1002304-34-8
Molecular Formula C22H17N5O2
Molecular Weight 383.4
Monoisotopic Mass 383.138224813
MDL number N/A
InChIKey HEAIZQNMNCHNFD-UHFFFAOYSA-N
InChi Code InChI=1S/C22H17N5O2/c1-28-16-7-8-17-19(13-16)23-12-11-20(17)29-14-22-25-24-21-10-9-18(26-27(21)22)15-5-3-2-4-6-15/h2-13H,14H2,1H3
SMILES COC1=CC2=NC=CC(OCC3=NN=C4C=CC(=NN34)C3=CC=CC=C3)=C2C=C1
Form Powder
Color N/A
Solubility  DMSO 0.25 mg/mL (<1 mM)

Water <1 mg/mL (<1 mM)

Ethanol <1 mg/mL (<1 mM)

Storage Temp.  -20°C
Shelf life >2 years if stored properly
Handling Protect from air and moisture
Application An c-Met inhibitor

 


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RIDADR NONH for all modes of transport

References:

[1]. Boezio AA, et al. Bioorg Med Chem Lett. 2009, 19(22), 6307-6312.

[2]. Liu X, et al. Trends Mol Med. 2010,16(1), 37-45.

[1]. Albrecht BK, et al. J Med Chem. 2008, 51(10), 2879-2882.

1 review for AMG208 (1002304-34-8)

  1. Rated 5 out of 5

    Cofttek

    Never had such good experience before,The AMG208 (1002304-34-8) is high purity,also customer service is pretty nice !gotta try!!

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