Showing 1–12 of 22 results

CAS NO. PRODUCT NAME OVERVIEW
    934162-61-5 A-966492 (934162-61-5)

    A-966492 is a novel and potent inhibitor of PARP1 and PARP2 with Ki of 1 nM and 1.5 nM, respectively.

    328543-09-5 AG14361 (328543-09-5)

    AG14361 is a potent PARP-1 inhibitor, with a Ki of < 5 nM, and in permeabilized SW620 and intact SW620 cells, the IC50s are 29 nM and 14 n...

    1645286-75-4 AZ6102 (1645286-75-4)

    AZ6102 is a potent TNKS1/2 inhibitor (IC50=3/1 nM) that has 100-fold selectivity against other PARP family enzymes (IC50: 0.5-3 μM) and shows...

    1174043-16-3 AZD2461 (1174043-16-3)

    AZD2461 is a novel and potent PARP inhibitor with IC50s of 5 nM, 2 nM and 200 nM for PARP1, PARP2 and PARP3, respectively. Its lower affinity...

    66611-37-8 BGP-15 (66611-37-8)

    BGP-15 is a novel poly(ADP-ribose) polymerase inhibitor, with roles in DNA repair and apoptosis…

    1207456-01-6 BMN673 (1207456-01-6)

    BMN 673 is a novel PARP inhibitor with IC50 of 0.58 nM. It is also a potent inhibitor of PARP-2, but does not inhibit PARG and is highly sens...

    868540-17-4 Carfilzomib (PR171) (868540-17-4)

    Carfilzomib(PR171) is an irreversible proteasome inhibitor and antineoplastic agent that is used in treatment of refractory multiple myeloma....

    134381-21-8 Epoxomicin (134381-21-8)

    Epoxomicin is a selective proteasome inhibitor with anti-inflammatory activity, inhibits primarily the CH-L activity of the 20S proteasome, w...

    415903-37-6 Grapiprant (415903-37-6)

    Grapiprant, also known as AT-001 and CJ-023, is a drug from the piprant class. These molecules were derived from acylsulfonamide and are char...

    133407-82-6 MG132 (133407-82-6)

    MG132 is a potent cell-permeable proteasome and calpain inhibitor with IC50s of 0.1 and 1.2 μM for the inhibition of proteasome and calpain, ...

    1038915-60-4 MK4827 (Niraparib) (1038915-60-4)

    MK-4827(Niraparib) is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM; with great activity in cancer cells with mutant BRCA-1...

    489402-47-3 ML213 (489402-47-3)

    ML213 is a selective activator of Kv7.2 and Kv7.4 channels, enhances Kv7.2 and Kv7.4 channels with EC50s of 230 and 510 nM, respectively.

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