Showing 1–12 of 22 results
|CAS NO.||PRODUCT NAME||OVERVIEW|
A-966492 is a novel and potent inhibitor of PARP1 and PARP2 with Ki of 1 nM and 1.5 nM, respectively.
AZ6102 is a potent TNKS1/2 inhibitor (IC50=3/1 nM) that has 100-fold selectivity against other PARP family enzymes (IC50: 0.5-3 μM) and shows...
AZD2461 is a novel and potent PARP inhibitor with IC50s of 5 nM, 2 nM and 200 nM for PARP1, PARP2 and PARP3, respectively. Its lower affinity...
BGP-15 is a novel poly(ADP-ribose) polymerase inhibitor, with roles in DNA repair and apoptosis…
|868540-17-4||Carfilzomib (PR171) (868540-17-4)||
Carfilzomib(PR171) is an irreversible proteasome inhibitor and antineoplastic agent that is used in treatment of refractory multiple myeloma....
Epoxomicin is a selective proteasome inhibitor with anti-inflammatory activity, inhibits primarily the CH-L activity of the 20S proteasome, w...
Grapiprant, also known as AT-001 and CJ-023, is a drug from the piprant class. These molecules were derived from acylsulfonamide and are char...
MG132 is a potent cell-permeable proteasome and calpain inhibitor with IC50s of 0.1 and 1.2 μM for the inhibition of proteasome and calpain, ...
|1038915-60-4||MK4827 (Niraparib) (1038915-60-4)||
MK-4827(Niraparib) is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM; with great activity in cancer cells with mutant BRCA-1...
ML213 is a selective activator of Kv7.2 and Kv7.4 channels, enhances Kv7.2 and Kv7.4 channels with EC50s of 230 and 510 nM, respectively....
- PARP&Proteasome (22)
- Akt &GSK-3 (37)
- ATM&ATR (36)
- Bcl-2&P53 (11)
- c-Kit&c-Met (25)
- CDK&Aurora kinase (36)
- Chk&Rho (8)
- HDAC&PLK (0)
- HER2&FLT3 (13)
- IGF-1R&ALK (21)
- JAK&Bcr-Abl (4)
- MEK&P38 MAPK (22)
- PDGFR&FGFR (20)
- PI3K&mTOR (80)
- PKC&ROCK (21)
- Raf&HSP (29)
- S6 kinase&PKD-1 (9)
- STAT&Axl (9)
- TGF-beta&Smad (15)
- VEGFR&EGFR (42)
- DNA&RNA Synthesis (20)
- ERK&JNK (11)
- Gamma Secretase (12)
- GPCR&G protein (53)
- Histone Methytransferase (29)
- HIV&HCV Protease (27)
- Wnt&Beta catenin (17)
- Other (0)