Showing 1–12 of 22 results
|CAS NO.||PRODUCT NAME||OVERVIEW|
APS-2-79 is an antagonist of MEK phosphorylation by RAF through direct binding of the KSR active site.
|606143-89-9||Binimetinib (MEK162) (606143-89-9)||
MEK162(ARRY-438162; ARRY-162) is a potent inhibitor of MEK1/2 with IC50 of 12 nM.Binimetinib, also known as MEK162 (ARRY-162), is an oral, hi...
|285983-48-4||BIRB 796 (Doramapimod) (285983-48-4)||
BIRB 796 (Doramapimod) is a highly selective p38α MAPK inhibitor with Kd of 0.1 nM, 330-fold greater selectivity versus JNK2, weak inhibition...
BIX02188 is a selective inhibitor of MEK5 with IC50 of 4.3 nM, also inhibits ERK5 catalytic activity with IC50 of 810 nM, and does not inhibi...
BMS-265246 is a potent and selective CDK1/2 inhibitor with IC50 of 6 nM/9 nM. It is 25-fold more selective for CDK1/2 than CDK4….<...
BS-181 is a highly selective CDK7 inhibitor with IC50 of 21 nM. It is more than 40-fold selective for CDK7 than CDK1, 2, 4, 5, 6, or 9…...
|934660-93-2||Cobimetinib (GDC-0973, RG7420) (934660-93-2)|
Cobimetinib(GDC-0973; XL518) is a potent, highly selective inhibitor of mitogen-activated protein kinase kinase(MEK1/2)…….
Flavopiridol competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CD...
GDC-0623 is a potent, ATP-uncompetitive inhibitors of MEK1(Ki=0.13 nM, +ATP); 6-fold weaker potency against HCT116 (KRAS(G13D), EC50=42 nM) v...
HMN-214 is a prodrug of HMN-176, which alters the cellular spatial orientation of Plk1. HMN-214 (IVX-214) is a potent inhibitor of Polo-like ...
Losmapimod (GW856553X; SB856553; GSK-AHAB) is a selective, potent, and orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and ...
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