Showing 1–12 of 22 results
|CAS NO.||PRODUCT NAME||OVERVIEW|
APS-2-79 is an antagonist of MEK phosphorylation by RAF through direct binding of the KSR active site.
|606143-89-9||Binimetinib (MEK162) (606143-89-9)||
MEK162(ARRY-438162; ARRY-162) is a potent inhibitor of MEK1/2 with IC50 of 12 nM.Binimetinib, also known as MEK162 (ARRY-162), is an oral, hi...
|285983-48-4||BIRB 796 (Doramapimod) (285983-48-4)||
BIRB 796 (Doramapimod) is a highly selective p38α MAPK inhibitor with Kd of 0.1 nM, 330-fold greater selectivity versus JNK2, weak inhibition...
BIX02188 is a selective inhibitor of MEK5 with IC50 of 4.3 nM, also inhibits ERK5 catalytic activity with IC50 of 810 nM, and does not inhibi...
BMS-265246 is a potent and selective CDK1/2 inhibitor with IC50 of 6 nM/9 nM. It is 25-fold more selective for CDK1/2 than CDK4….<...
BS-181 is a highly selective CDK7 inhibitor with IC50 of 21 nM. It is more than 40-fold selective for CDK7 than CDK1, 2, 4, 5, 6, or 9…...
|934660-93-2||Cobimetinib (GDC-0973, RG7420) (934660-93-2)|
Cobimetinib(GDC-0973; XL518) is a potent, highly selective inhibitor of mitogen-activated protein kinase kinase(MEK1/2)…….
Flavopiridol competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CD...
GDC-0623 is a potent, ATP-uncompetitive inhibitors of MEK1(Ki=0.13 nM, +ATP); 6-fold weaker potency against HCT116 (KRAS(G13D), EC50=42 nM) v...
HMN-214 is a prodrug of HMN-176, which alters the cellular spatial orientation of Plk1. HMN-214 (IVX-214) is a potent inhibitor of Polo-like ...
Losmapimod (GW856553X; SB856553; GSK-AHAB) is a selective, potent, and orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and ...
- PARP&Proteasome (22)
- Akt &GSK-3 (37)
- ATM&ATR (35)
- Bcl-2&P53 (11)
- c-Kit&c-Met (25)
- CDK&Aurora kinase (21)
- Chk&Rho (8)
- HDAC&PLK (0)
- HER2&FLT3 (13)
- IGF-1R&ALK (21)
- JAK&Bcr-Abl (4)
- MEK&P38 MAPK (22)
- PDGFR&FGFR (20)
- PI3K&mTOR (55)
- PKC&ROCK (21)
- Raf&HSP (0)
- S6 kinase&PKD-1 (9)
- STAT&Axl (9)
- TGF-beta&Smad (15)
- VEGFR&EGFR (42)
- DNA&RNA Synthesis (20)
- ERK&JNK (11)
- Gamma Secretase (12)
- GPCR&G protein (51)
- Histone Methytransferase (19)
- HIV&HCV Protease (13)
- Wnt&Beta catenin (2)
- Other (0)