Showing all 12 results
|CAS NO.||PRODUCT NAME||OVERVIEW|
Avagacestat (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, ...
|208255-80-5||DAPT (GSI-IX) (208255-80-5)|
DAPT (GSI-IX) is a novel γ-secretase inhibitor, which inhibits Aβ production with IC50 of 20 nM in HEK 293 cells.
Enasidenib is a oral potent, selective, reversible inhibitor of mutant IDH2. Enasidenib, aslo known as AG-221 and CC-90007, is a potent and s...
FLI-06 is a novel inhibitor of Notch signaling with EC50 of 2.3 μM. FLI-06 is a Notch inhibitor and the early secretory pathway inhibitor. FL...
ID-8 is a DYRK inhibitor, and sustains embryonic stem cell self-renewal in long-term culture. ID-8 is a DYRK inhibitor. ID-8 could support Wn...
JNJ-7777120 is the first potent and selective non-imidazole histamine H4 receptor antagonist with Ki of 4.5 nM, exhibits >1000-fold select...
LDN-57444 is a reversible, competitive proteasome inhibitor for Uch-L1 with IC50 of 0.88 μM, 28-fold selectivity over isoform Uch-L3.
|603139-19-1||Odanacatib (MK-0822) (603139-19-1)||
Odanacatib (MK 0822) is a potent, selective, and neutral inhibitor of cathepsin K (human/rabbit) with IC50 of 0.2 nM/1 nM, and demonstrated h...
|960374-59-8||ONX0914 (PR-957) (960374-59-8)||
ONX-0914 (PR-957) is a potent and selective immunoproteasome inhibitor with minimal cross-reactivity for the constitutive proteasome.
RO4929097 is a γ secretase inhibitor with IC50 of 4 nM, inhibiting cellular processing of Aβ40 and Notch with EC50 of 14 nM and 5 nM, respect...
TAK-875 is a selective GPR40 agonist with EC50 of 14 nM, 400-fold more potent than oleic acid. TAK-875 is a novel, orally available, selectiv...
|209984-56-5||YO-01027 (Dibenzazepine) (209984-56-5)||
YO-01027 (Dibenzazepine) is a dipeptidic γ-secretase inhibitor with IC50 of 2.6 nM and 2.9 nM in cell-free assays for APPL and Notch cleavage...
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