Showing 1–12 of 21 results

CAS NO. PRODUCT NAME OVERVIEW
    844442-38-2 AT7519 (844442-38-2)

    AT7519 is an inhibitor of multiple cyclin-dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhibi...

    865783-99-9 Briciclib (865783-99-9)

    Briciclib is a benzyl styryl sulfone analog, and a disodium phosphate ester prodrug of ON 013100, with potential antineoplastic activity.

    ...
    1421693-22-2 CDKI-73 (1421693-22-2)

    CDKI-73 is a potent CDK9 inhibitor with Ki of 4 nM. It shows selective toxicity to CLL cells(LD50=80 nM) versus normal B cell and normal CD34...

    199986-75-9 CVT-313 (NG-26) (199986-75-9)

    CVT-313 is a potent, selective, reversible, and ATP-competitive inhibitor of CDK2 (IC50 = 0.5 uM for Cdk2/A and Cdk2/E; 4.2 uM for Cdk1/B; 21...

    942918-07-2 GSK1070916 (942918-07-2)

    GSK1070916 is a potent Aurora B/C kinase inhibitor (with IC50 of 3.5 nM/6.5 nM) with broad antitumor activity in tissue culture cells and hum...

    1346546-69-7 GSK872 (1346546-69-7)

    GSK872 is a a receptor interacting protein kinase-3 (RIP3) inhibitor. GSK872 inhibits TNF- and virus-induced necrosis in 3T3-SA fibroblasts. ...

    1073485-20-7 LDC000067 (1073485-20-7)

    LDC000067 is a highly selective CDK9 inhibitor with IC50 of 44 nM, 55/125/210/ >227/ >227-fold selectivity over CDK2/1/4/6/7….

    1453834-21-3 LDC4297 (1453834-21-3)

    LDC4297 is a novel CDK7 inhibitor (IC50=0.13±0.06 nM for CDK7 versus IC50s between 10 nM and 10,000 nM for all other analyzed CDKs)..

    ...

    1010085-13-8 MK-5108 (VX-689) (1010085-13-8)

    MK-5108 (VX-689) is a highly selective Aurora A inhibitor, MK-5108 has been used in trials studying the treatment of Cancer, Neoplasms, Tumor...

    1357470-29-1 ON123300 (1357470-29-1)

    ON123300 is a potent multikinase inhibitor and may be potential useful for brain tumor chemotherapy…..

    718630-59-2 PHA-793887 (718630-59-2)

    PHA-793887 is a potent, ATP-competitive CDK inhibitor, can inhibit Cdk2, Cdk1, Cdk4, and Cdk9 with IC50s of 8 nM, 60 nM, 62 nM and 138 nM, re...

    845714-00-3 PHA767491 (845714-00-3)

    PHA-767491 is a potent, ATP-competitive dual cdc7/cdk9 inhibitor (IC50 values are 10 and 34 nM respectively) that prevents initiation of DNA ...

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