Showing 1–12 of 36 results
|CAS NO.||PRODUCT NAME||OVERVIEW|
AR-42 is a novel HDAC inhibitor, exhibits biologic activity against malignant mast cell lines via down-regulation of constitutively activated...
AT7519 is an inhibitor of multiple cyclin-dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhibi...
AZD5438 is a potent inhibitor of CDK1/2/9 with IC50 of 16 nM/6 nM/20 nM. It is less potent to CDK5/6 and also inhibits GSK3β. Phase 1.
Briciclib is a benzyl styryl sulfone analog, and a disodium phosphate ester prodrug of ON 013100, with potential antineoplastic activity....
CDKI-73 is a potent CDK9 inhibitor with Ki of 4 nM. It shows selective toxicity to CLL cells(LD50=80 nM) versus normal B cell and normal CD34...
|199986-75-9||CVT-313 (NG-26) (199986-75-9)||
CVT-313 is a potent, selective, reversible, and ATP-competitive inhibitor of CDK2 (IC50 = 0.5 uM for Cdk2/A and Cdk2/E; 4.2 uM for Cdk1/B; 21...
|779353-01-4||Dinaciclib (SCH727965) (779353-01-4)||
Dinaciclib (SCH727965) is a novel and potent CDK inhibitor for CDK2, CDK5, CDK1 and CDK9 with IC50 of 1 nM, 1 nM, 3 nM and 4 nM, respectively...
GSK1070916 is a potent Aurora B/C kinase inhibitor (with IC50 of 3.5 nM/6.5 nM) with broad antitumor activity in tissue culture cells and hum...
GSK872 is a a receptor interacting protein kinase-3 (RIP3) inhibitor. GSK872 inhibits TNF- and virus-induced necrosis in 3T3-SA fibroblasts. ...
JNJ-7706621 is pan-CDK inhibitor with the highest potency on CDK1/2 with IC50 of 9 nM/4 nM and showing >6-fold selectivity for CDK1/2 than...
LDC000067 is a highly selective CDK9 inhibitor with IC50 of 44 nM, 55/125/210/ >227/ >227-fold selectivity over CDK2/1/4/6/7….
LDC4297 is a novel CDK7 inhibitor (IC50=0.13±0.06 nM for CDK7 versus IC50s between 10 nM and 10,000 nM for all other analyzed CDKs)..
- PARP&Proteasome (22)
- Akt &GSK-3 (37)
- ATM&ATR (36)
- Bcl-2&P53 (11)
- c-Kit&c-Met (25)
- CDK&Aurora kinase (36)
- Chk&Rho (8)
- HDAC&PLK (0)
- HER2&FLT3 (13)
- IGF-1R&ALK (21)
- JAK&Bcr-Abl (4)
- MEK&P38 MAPK (22)
- PDGFR&FGFR (20)
- PI3K&mTOR (80)
- PKC&ROCK (21)
- Raf&HSP (29)
- S6 kinase&PKD-1 (9)
- STAT&Axl (9)
- TGF-beta&Smad (15)
- VEGFR&EGFR (42)
- DNA&RNA Synthesis (20)
- ERK&JNK (11)
- Gamma Secretase (12)
- GPCR&G protein (53)
- Histone Methytransferase (29)
- HIV&HCV Protease (27)
- Wnt&Beta catenin (17)
- Orther (1)