Showing all 11 results
|CAS NO.||PRODUCT NAME||OVERVIEW|
A-1210477 is a potent and selective MCL-1 inhibitor with Ki and IC50 of 0.454 nM and 26.2 nM, respectively, >100-fold selectivity over oth...
FX1 is a potent and specific BCL6 inhibitor, with an IC50 of around 35 μM.FX1 is an inhibitor of the B cell lymphoma 6 (BCL6). ….<...
NSC59984 induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway. The EC50 of NSC59984 in most cancer cells is s...
NVP-CGM097(CGM-097) is a potent and selective MDM2 inhibitor; an orally bioavailable HDM2 antagonist with potential antineoplastic activity...
|803712-79-0||Obatoclax Mesylate (GX15-070) (803712-79-0)||
Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resi...
RG7112 is the first clinical small-molecule MDM2 inhibitor designed to occupy the p53-binding pocket of MDM2….
RG7388 is an oral, selective, small molecule MDM2 antagonist that inhibits binding of MDM2 to p53. Idasanutlin, also known as RG7388 and RO55...
RO8994 is a highly potent and selective series of spiroindolinone small-molecule MDM2 inhibitor, with IC50 of 5 nM (HTRF binding assays) and ...
Spautin-1 is a novel autophagy inhibitor, IM inhibited the growth of K562 cells with IC50 of 1.03 μM. In contrast, co-treatment...
Tenovin-3 is able to increase p53 levels, determined in MCF-7 cells treated for 6hr at 10 μM.Tenovin-3 is a p53 activator and an inhibitor of...
WEHI-539, has high affinity (subnanomolar) and selectivity for BCL-XL and potently kills cells by selectively antagonizing its prosurvival ac...
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