Showing 1–12 of 37 results

CAS NO. PRODUCT NAME OVERVIEW
    552325-73-2 A-674563 (552325-73-2)

    A-674563 is a potent, orally available Akt1 inhibitor with an IC50 value of 11nM. Also displays activity against PKA and CDK2 with IC50 value...

    1047634-63-8 Afuresertib (GSK2110183) (1047634-63-8)

    GSK2110183 is an orally bioavailable, selective, ATP-competitive and potent pan-Aktinhibitor with IC50s of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 r...

    487021-52-3 AR-A014418 (487021-52-3)

    AR-A014418 is an ATP-competitive, and selective GSK3β inhibitor with IC50 and Ki of 104 nM and 38 nM, without significant inhibition on 26 ot...

    1056901-62-2 AT13148 (1056901-62-2)

    AT13148 is a novel, oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity; AKT, p70S6K, PKA, ROCK, and SGK inhib...

    857531-00-1 AT7867 (857531-00-1)

    AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively; little a...

    612487-72-6 AZD1080 (612487-72-6)

    AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor, inhibits human GSK3α and GSK3β with Ki of 6.9 nM and 31 nM, respective...

    486424-20-8 AZD2858 (486424-20-8)

    AZD2858 is a potent and GSK-3 inhibitor with an IC50 of 68 nM. AZD-2858 inhibits tau phosphorylation at the S396 site, and it activates Wnt s...

    1143532-39-1 AZD5636 (1143532-39-1)

    AZD5363, also known as Capivasertib, is an orally available inhibitor of the serine/threonine protein kinase AKT (protein kinase B) with pote...

    188011-69-0 Bikinin (188011-69-0)

    Bikinin(Abrasin) is a potent inhibitor of plant GSK-3/Shaggy-like kinase; activates BR signaling downstream of the BR receptor.

    1007207-67-1 CH5132799 (1007207-67-1)

    CH5132799 inhibits class I PI3Ks, particularly PI3Kα with IC50 of 14 nM; less potent to PI3Kβδγ, while sensitive in PIK3CA mutations cell lin...

    252935-94-7 CHIR-98014 (252935-94-7)

    CHIR-98014 is a selective GSK3 inhibitor with IC50s of 0.65 nM and 0.58 nM for GSK-3α and GSK-3β; potentiate insulin activation of glucose tr...

    915019-65-7 Dactolisib (BEZ235) (915019-65-7)

    BEZ235 (NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110/// and mTOR(p70S6K) with IC50 of 4 nM/5 nM/7 nM/75 nM/6 nM, re...

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