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What is Palmitoylethanolamide (PEA)?

Palmitoylethanolamide (PEA) is a fatty molecule that is produced in small amounts with the body, mostly in response to tissue damage or tissue or muscle injury. PEA is naturally produced by the body’s immune system in response to pain or inflammation. Palmitoylethanolamide, also known as PEA is a naturally-occurring lipid that falls under the fatty acid amides group. Though this compound is produced by the body’s immune system, it also exists in animals and plants and therefore, can be derived from external sources, such as egg yolk, soy lecithin, alfalfa, milk, peanuts and soybean. PEA has power analgesic properties and it, therefore, is able to influence several key physiological functions within the body.

PEA is mostly taken for anti-inflammatory and pain-reducing purposes. So, how does PEA work once inside the body? Once inside the body, PEA binds itself to a target site that switches off the inflammatory function of the cell after the binding process. More importantly, some research shows that the analgesic effect of PEA can be attributed to the compound’s ability to hamper the working of specialized immune cells responsible for transmitting the pain signals. Irrespective of what the exact mechanism is, one thing is certain that PEA provides relief from neuropathic pain as well as inflammation.

However, the human body produces PEA in very a small amount and more often than not, this amount isn’t enough to suppress inflammation and pain and thus, people are often advised to take PEA supplements. Alleviating pain and inflammation is only one of the many benefits of PEA. Let us look at some of the Palmitoylethanolamide (PEA) benefits.

Why We Need Palmitoylethanolamide (PEA)

Over the last few years, Palmitoylethanolamide (PEA) has witnessed a sudden surge in its popularity. Though the therapeutic properties of PEA were discovered back in the 1950s and since then, scientists and researchers have extensively studied this compound, over the last few years, the interest in PEA has grown manifold. This is primarily due to the protective and healing role that the compound can play within the body as well as its ability to handle a wide variety of inflammation and neuropathic issues.


Palmitoylethanolamide (PEA) Uses

Over the last few years, the popularity of Palmitoylethanolamide has witnessed a huge surge, primarily because people have become more aware of its several uses. These days, people use Palmitoylethanolamide primarily for its analgesic effect, but it is also often prescribed against serious illnesses, such as Lou Gehrig’s disease, diabetic neuropathy, multiple sclerosis, fibromyalgia, carpal tunnel syndrome, glaucoma, autism, eczema, endometriosis as well as a variety of other disorders. These days, Palmitoylethanolamide (PEA) supplements are also being used by people to promote weight loss. However, more research needs to be done in this area.

Palmitoylethanolamide (PEA) Benefits


Early Research Shows Promising Results in the Treatment of Lou Gehrig’s Disease

Lou Gehrig’s Disease or Amyotrophic lateral sclerosis (ALS) is a life-threatening disease that leads to motor-neuron degeneration and eventually progressive paralysis. Early research shows that palmitoylethanolamide when taken with riluzole, may help improve this condition. PEA is an endocannabinoid that improves pulmonary function in ALS patients.①.Gabriella Contarini, Davide Franceschini, Laura Facci, Massimo Barbierato, Pietro Giusti & Morena Zusso (2019)

It Helps with Carpal Tunnel Syndrome

Carpal Tunnel Syndrome is a condition that affects the hand. People suffering from this condition experience tingling and numbness in the hand. The condition affects the entire hand, including all fingers except the small finger. A 2017-study revealed that PEA can be effectively used to treat compressive syndromes, including the Carpal Tunnel Syndrome. Thus, PEA supplements can be taken to get under control the pain and discomfort caused by the Carpal Tunnel Syndrome.

It Is Also Effective Against Diabetic Neuropathy and Fibromyalgia

Diabetic neuropathy is diabetes-induced nerve damage. One of the most common symptoms of diabetic neuropathy is a pain in legs and feet. Fibromyalgia, on the other hand, is a condition that affects the musculoskeletal system. Alongside fatigue and memory issues, the most common symptom of fibromyalgia is a pain in the entire musculoskeletal system.

Both diabetic neuropathy and fibromyalgia are painful conditions that are not very uncommon. Fortunately, the pain associated with both of these conditions can be controlled with the use of palmitoylethanolamide.


④ It Can Be Used to Treat Symptoms of Multiple Sclerosis

Multiple Sclerosis is a condition in which the immune system begins to attack the myelin that covers the nerves, which in turn, leads to reduced or no communication between the brain and the rest of the body. The disease can be completely disabling. However, preliminary research shows that PEA, when given in combination with interferon-beta1a, can help alleviate the symptoms linked with Multiple Sclerosis.

⑤ It Is Effective Against Glaucoma and Temporomandibular Disorders

Glaucoma is a condition that affects the optic nerve and is a leading cause of blindness among people aged 60 and above. TMJ disorders, on the other hand, cause jaw pain. Research shows that palmitoylethanolamide or PEA can be used to treat the pain caused by both of these conditions.

Other Benefits

Other than the uses mentioned above, PEA is also recommended for nerve pain as well as a post-surgery analgesic. In some cases, it has also been used to treat other conditions, such as headaches, depression, eczema, endometriosis, autism, kidney disease and vulvar pain. PEA has also shown some effectiveness against weight gain. However, more research is needed in these areas.

Palmitoylethanolamide (PEA) Dosage

Over the years, different studies have used different dosage and hence, no dosage can be deemed perfect. However, people are advised to keep their Palmitoylethanolamide (PEA) dosage intake under 300-1,200 mg per day. Those taking Palmitoylethanolamide supplements are advised to take 350-400 mg thrice a day and the dosage duration should not exceed 2 months in total.

Is Palmitoylethanolamide (PEA) safe?

Though Palmitoylethanolamide is well-tolerated by the body, in case people notice any side-effects, they are advised to reduce the dosage amount to 400 mg a day.

More importantly, the compound should not be taken for more than three months. Sustained PEA use can lead to stomach issues. However, it is a side-effect that has rarely been noticed. More importantly, PEA should not be used on skin and pregnant and breastfeeding women should stay away from its use since there is not enough research or evidence to claim that the drug is safe for these groups. Similarly, if you are suffering from any condition, it is always best to consult with a physician before taking a supplement like Palmitoylethanolamide.

Where Should I Buy Palmitoylethanolamide (PEA) Powder in Bulk?

If you are planning to foray into the PEA supplements markets, now is the perfect time to do so. Though curiosity, as well as the demand for this product, is increasing, there aren’t many companies catering to this demand. However, if you want to set up a Palmitoylethanolamide supplements company, the first you must do is find a raw materials supplier than you can trust and rely on. This brings us to an important question: where should I buy Palmitoylethanolamide (PEA) powder in bulk?

The answer is Cofttek. Cofttek is a supplement raw materials manufacturer that came into existence in 2008. The company takes immense pride in its highly-skilled R&D team that works round the clock to ensure that the raw material being supplied to clients is of very high quality. More importantly, the company invests heavily on biotechnology and analytical testing. All the products sold by the company are created in their large-scale, high-tech biochemical factory that boasts of mature supplier systems and latest technical facilities. It is this commitment that the company has made to produce high-quality raw materials that has made Cofttek a well-recognized name in the raw material market. Today, it has clients across the world.

The Palmitoylethanolamide powder supplied by the company comes in batches of 25 kgs (Palmitoylethanolamide (PEA) Powder). More importantly, the company has a dedicated sales team. So, all your queries and concerns will always be dealt with at priority. If you are looking to buy Palmitoylethanolamide powder in bulk, this is the only place to shop: cofttek.com.

Article by:Dr. Zeng

Article by:

Dr. Zeng

Co-founder, the company’s core administration leadership; PhD received from Fudan University in organic chemistry. More than nine years of experience in organic chemistry and drug design synthesis; nearly 10 research papers published in authoritative journals, with more than five Chinese patents.


(1) Gabriella Contarini, Davide Franceschini, Laura Facci, Massimo Barbierato, Pietro Giusti & Morena Zusso (2019) ‘ A co-ultra micronized palmitoylethanolamide/luteolin composite mitigates clinical score and disease-relevant molecular markers in a mouse model of experimental autoimmune encephalomyelitis’, Journal of Neuroinflammation,

(2) Maria Beatrice Passavanti, Aniello Alfieri, Maria Caterina Pace, Vincenzo Pota, Pasquale Sansone, Giacomo Piccinno, Manlio Barbarisi, Caterina Aurilio & Marco Fiore (2019) ‘ Clinical applications of palmitoylethanolamide in pain management: protocol for a scoping review’, Systematic Reviews volume,

(3) Eleonora Palma, Jorge Mauricio Reyes-Ruiz, Diego Lopergolo, Cristina Roseti, Cristina Bertollini, Gabriele Ruffolo Pierangelo Cifelli, Emanuela Onesti, Cristina Limatola, Ricardo Miledi, Maurizio Inghillerid (2016) ‘Acetylcholine receptors from human muscle as pharmacological targets for ALS therapy’, Proc Natl Acad Sci U S A.,

(4) Di Cesare Mannelli, G. D’Agostino, A. Pacini, R. Russo, M. Zanardelli, C. Ghelardini, A. Calignano (2013) ‘Palmitoylethanolamide Is a Disease-Modifying Agent in Peripheral Neuropathy: Pain Relief and Neuroprotection Share a PPAR-Alpha-Mediated Mechanism’, Mediators Inflamm.




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