Palmitoylethanolamide (PEA): Benefits, Dosage, Uses, Supplement

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What is Palmitoylethanolamide used for?

Palmitoylethanolamide (PEA) belong to endocannabinoid family, a group of fatty acid amides. PEA has been proven to have analgesic and anti-inflammatory activity and has been used in several controlled studies focused on the management of chronic pain among adult patients with different underlying clinical conditions.

Does PEA get you high?

Taken in doses of 500mg-1.5g per dosage, every few hours, PEA provides the user a feeling of euphoria, energy, stimulation, and overall well being. Esp when combined with the mao-b inhibitor, hordenine, PEA takes on a whole new level of euphoria and overall happiness.

What are the side effects of pea?

There are no known problematic side-effects. PEA can be taken together with any other substance. It enhances the pain-relieving effect of classic analgesics and anti-inflammatories. Palmitoylethanolamide can be used in combination with other substances without any side effects.

Is phenethylamine legal?

Phenethylamine (PEA) is an organic compound, natural monoamine alkaloid, and trace amine, which acts as a central nervous system stimulant in humans.

How long does PEA last?

When taken by mouth: Taking palmitoylethanolamide is POSSIBLY SAFE for most adults when used for up to 3 months. Possible side effects, such as upset stomach, are very rare. There isn’t enough reliable information to know if palmitoylethanolamide is safe to use for longer than 3 months.

Will phenylethylamine fail a drug test?

It’s important to note that melatonin isn’t strictly regulated by the Food and Drug Administration (FDA). That’s because melatonin isn’t considered a drug. Therefore, it can be sold as a dietary supplement like vitamins and minerals, which aren’t closely monitored by the FDA.

Is Pea supplement safe?

PEA is a natural substance produced by the body; it is very effective and safe to use as a supplement for pain and inflammation.

How long does it take for Peas to kick in?

Peas take 7 to 30 days to germinate. Peas will germinate faster if soil temperatures are 65 to 70 degrees Fahrenheit. You can speed up the germination process by soaking the peas for 24 to 48 hours before planting. Of course, there are other factors that affect how quickly peas will germinate and grow.

Can you buy phenylethylamine in stores?

These supplements when consumed help in increasing the level of brain activity and decrease stress. It is available over the counter, and one does not need a prescription to purchase it. Phenylethylamine is also used to enhance focus and concentration.

How long does it take for pea to work?

We developed this treatment schedule after treating hundreds of neuropathic pain patients. Based on our clinical experience, we hypothesize that starting with the sublingual form of PEA for at least 10 days might help to quickly reach sufficient therapeutic levels of PEA.

Does pea help with sleep?

A type of fat found naturally in the body could be the key to a good night’s sleep. Researchers are hoping the molecule known as PEA – or palmitoylethanolamide – could not only help with sleep but also fight pain and reduce inflammation.

Is Pea a stimulant?

Phenethylamine (PEA) is an organic compound, natural monoamine alkaloid, and trace amine, which acts as a central nervous system stimulant in humans.

How long does phenylethylamine stay in your system?

It can be taken together with other pain medication or alone, as advised by your health care professional, to support pain relief. P.E.A. can also help reduce reliance on stronger pain medications that cause unwanted side-effects. Maximum benefit could take up to 3 months but results are typically seen in 4-6 weeks.

Does chocolate contain phenylethylamine?

Chocolate has the highest concentration in any food of phenylethylamine, which is the chemical produced in the brain when a person is in love. Yet the role of the “chocolate amphetamine” is disputed. Most if not all chocolate-derived phenylethylamine is metabolized before it reaches the CNS.

Where is phenylethylamine found?

In mammals, phenethylamine is produced from the amino acid L-phenylalanine by the enzyme aromatic L-amino acid decarboxylase via enzymatic decarboxylation. In addition to its presence in mammals, phenethylamine is found in many other organisms and foods, such as chocolate, especially after microbial fermentation.

How does PEA work for pain?

Research has shown that PEA possesses anti-inflammatory and anti-nociceptive properties and taking it regularly may boost your body’s natural response to pain by dampening the response of the nervous system cells which cause pain.

Does phenylethylamine get you high?

Taken in doses of 500mg-1.5g per dosage, every few hours, PEA provides the user a feeling of euphoria, energy, stimulation, and overall well being. Esp when combined with the mao-b inhibitor, hordenine, PEA takes on a whole new level of euphoria and overall happiness.

How long does Hordenine stay in your system?

In barley, hordenine levels reach a maximum within 5–11 days of germination, then slowly decrease until only traces remain after one month. Furthermore, hordenine is localized primarily in the roots.

Is Palmitoylethanolamide (PEA) safe?

Though Palmitoylethanolamide is well-tolerated by the body, in case people notice any side-effects, they are advised to reduce the dosage amount to 400 mg a day.

More importantly, the compound should not be taken for more than three months. Sustained PEA use can lead to stomach issues. However, it is a side-effect that has rarely been noticed. More importantly, PEA should not be used on skin and pregnant and breastfeeding women should stay away from its use since there is not enough research or evidence to claim that the drug is safe for these groups. Similarly, if you are suffering from any condition, it is always best to consult with a physician before taking a supplement like Palmitoylethanolamide.

Where can I get Palmitoylethanolamide?

The answer is Cofttek. Cofttek is a supplement raw materials manufacturer that came into existence in 2008. The company takes immense pride in its highly-skilled R&D team that works round the clock to ensure that the raw material being supplied to clients is of very high quality. More importantly, the company invests heavily on biotechnology and analytical testing. All the products sold by the company are created in their large-scale, high-tech biochemical factory that boasts of mature supplier systems and latest technical facilities. It is this commitment that the company has made to produce high-quality raw materials that has made Cofttek a well-recognized name in the raw material market. Today, it has clients across the world.

What is pea cream?

PEA cream is a cream that contains an optimal concentration of the natural and protective substance palmitoylethanolamide (PEA). The PEA cream therefore can be used as a good supplement for the effect of capsules in the body.

What is Palmitoylethanolamide (PEA)?

Palmitoylethanolamide (PEA) is a fatty molecule that is produced in small amounts with the body, mostly in response to tissue damage or tissue or muscle injury. PEA is naturally produced by the body’s immune system in response to pain or inflammation. Palmitoylethanolamide, also known as PEA is a naturally-occurring lipid that falls under the fatty acid amides group. Though this compound is produced by the body’s immune system, it also exists in animals and plants and therefore, can be derived from external sources, such as egg yolk, soy lecithin, alfalfa, milk, peanuts and soybean. PEA has power analgesic properties and it, therefore, is able to influence several key physiological functions within the body.

PEA is mostly taken for anti-inflammatory and pain-reducing purposes. So, how does PEA work once inside the body? Once inside the body, PEA binds itself to a target site that switches off the inflammatory function of the cell after the binding process. More importantly, some research shows that the analgesic effect of PEA can be attributed to the compound’s ability to hamper the working of specialized immune cells responsible for transmitting the pain signals. Irrespective of what the exact mechanism is, one thing is certain that PEA provides relief from neuropathic pain as well as inflammation.

Why We Need Palmitoylethanolamide (PEA)?

Over the last few years, Palmitoylethanolamide (PEA) has witnessed a sudden surge in its popularity. Though the therapeutic properties of PEA were discovered back in the 1950s and since then, scientists and researchers have extensively studied this compound, over the last few years, the interest in PEA has grown manifold. This is primarily due to the protective and healing role that the compound can play within the body as well as its ability to handle a wide variety of inflammation and neuropathic issues.

However, the human body produces PEA in very a small amount and more often than not, this amount isn’t enough to suppress inflammation and pain and thus, people are often advised to take PEA supplements. Alleviating pain and inflammation is only one of the many benefits of PEA.

What is PEA for fibromyalgia?

As a naturally occurring substance PEA supplements are classified in Australia, and many other countries, as a food product, not a drug. PEA has been shown to have antiinflammatory, antinociceptive, anticonvulsant and neuroprotective properties and is increasingly being used in the treatment of chronic pain.

What is neuropathic pain relief?

Neuropathic Pain Treatment Anticonvulsant and antidepressant drugs are often the first line of treatment. Some neuropathic pain studies suggest the use of non-steroidal anti-inflammatory drugs (NSAIDs), such as Aleve or Motrin, may ease pain. Some people may require a stronger painkiller.

How can I sleep with neuropathic pain?

Sleeping with your knees elevated may alleviate your painful symptoms by minimizing the pressure your lumbar discs place on your nerve roots. Lie flat on your back—keep your heels and buttocks in contact with the bed and bend your knees slightly towards the ceiling.

How can I treat nerve pain at home?

Strategies for Easing Nerve Pain. Keep on top of diabetes. If you have diabetes, keep blood sugar under control. Walk it off. Exercise releases natural painkillers called endorphins. Pamper your feet. If the feet are affected by nerve pain, it’s time to focus on good foot care.

Does drinking water help with neuropathy?

Not only is the warm water relaxing, but it can also boost circulation throughout your body. “It can provide instant relief,” Vinik says. But because diabetic neuropathy can lead to a loss of sensation, make sure the water’s not too hot before you get in.

Is Palmitoylethanolamide safe in pregnancy?

Not to be used by pregnant women. Palmitoylethanolamide may help nutritionally address inflammation and chronic pain. It should only be taken under medical supervision.

What is pea liquid used for?

PEA has demonstrated effectiveness for chronic pain of multiple types associated with many painful conditions, especially with neuropathic (nerve) pain, inflammatory pain and visceral pain such as endometriosis and interstitial cystitis.

Where does pea come from?

Palmitoylethanolamide is a chemical made from fat. It is found naturally in foods such as egg yolks and peanuts, and in the human body. It is also used as a medicine.

What is the treatment for pea?

Epinephrine should be administered in 1-mg doses intravenously/intraosseously (IV/IO) every 3-5 minutes during pulseless electrical activity (PEA) arrest. Higher doses of epinephrine have been studied and show no improvement in survival or neurologic outcomes in most patients.

Is Pea common in patients with hypovolemia?

In the spectrum of PEA etiologies, pseudo-PEA is frequently caused by hypovolemia, tachydysrhythmias, decreased cardiac contractility, or obstructions to circulation, such as pulmonary embolism, tamponade, and tension pneumothorax.

Which of the following is possible reversible causes of a pea rhythm?

Hypovolemia and hypoxia are the two most common causes of PEA. They are also the most easily reversible and should be at the top of any differential diagnosis. If the individual has a return of spontaneous circulation (ROSC), proceed to post-cardiac arrest care.

Uses

Over the last few years, the popularity of Palmitoylethanolamide has witnessed a huge surge, primarily because people have become more aware of its several uses. These days, people use Palmitoylethanolamide primarily for its analgesic effect, but it is also often prescribed against serious illnesses, such as Lou Gehrig’s disease, diabetic neuropathy, multiple sclerosis, fibromyalgia, carpal tunnel syndrome, glaucoma, autism, eczema, endometriosis as well as a variety of other disorders. These days, Palmitoylethanolamide (PEA) supplements are also being used by people to promote weight loss. However, more research needs to be done in this area.

Benefits

① Early Research Shows Promising Results in the Treatment of Lou Gehrig’s Disease

Lou Gehrig’s Disease or Amyotrophic lateral sclerosis (ALS) is a life-threatening disease that leads to motor-neuron degeneration and eventually progressive paralysis. Early research shows that palmitoylethanolamide when taken with riluzole, may help improve this condition. PEA is an endocannabinoid that improves pulmonary function in ALS patients.

② It Helps with Carpal Tunnel Syndrome

Carpal Tunnel Syndrome is a condition that affects the hand. People suffering from this condition experience tingling and numbness in the hand. The condition affects the entire hand, including all fingers except the small finger. A 2017-study revealed that PEA can be effectively used to treat compressive syndromes, including the Carpal Tunnel Syndrome. Thus, PEA supplements can be taken to get under control the pain and discomfort caused by the Carpal Tunnel Syndrome.

③ It Is Also Effective Against Diabetic Neuropathy and Fibromyalgia

Diabetic neuropathy is diabetes-induced nerve damage. One of the most common symptoms of diabetic neuropathy is a pain in legs and feet. Fibromyalgia, on the other hand, is a condition that affects the musculoskeletal system. Alongside fatigue and memory issues, the most common symptom of fibromyalgia is a pain in the entire musculoskeletal system.

Both diabetic neuropathy and fibromyalgia are painful conditions that are not very uncommon. Fortunately, the pain associated with both of these conditions can be controlled with the use of palmitoylethanolamide.

④ It Can Be Used to Treat Symptoms of Multiple Sclerosis

Multiple Sclerosis is a condition in which the immune system begins to attack the myelin that covers the nerves, which in turn, leads to reduced or no communication between the brain and the rest of the body. The disease can be completely disabling. However, preliminary research shows that PEA, when given in combination with interferon-beta1a, can help alleviate the symptoms linked with Multiple Sclerosis.

⑤ It Is Effective Against Glaucoma and Temporomandibular Disorders

Glaucoma is a condition that affects the optic nerve and is a leading cause of blindness among people aged 60 and above. TMJ disorders, on the other hand, cause jaw pain. Research shows that palmitoylethanolamide or PEA can be used to treat the pain caused by both of these conditions.

⑥ Other Benefits

Other than the uses mentioned above, PEA is also recommended for nerve pain as well as a post-surgery analgesic. In some cases, it has also been used to treat other conditions, such as headaches, depression, eczema, endometriosis, autism, kidney disease and vulvar pain. PEA has also shown some effectiveness against weight gain. However, more research is needed in these areas.

Dosage

Over the years, different studies have used different dosage and hence, no dosage can be deemed perfect. However, people are advised to keep their Palmitoylethanolamide (PEA) dosage intake under 300-1,200 mg per day. Those taking Palmitoylethanolamide supplements are advised to take 350-400 mg thrice a day and the dosage duration should not exceed 2 months in total.

References

(1) Gabriella Contarini, Davide Franceschini, Laura Facci, Massimo Barbierato, Pietro Giusti & Morena Zusso (2019) ‘ A co-ultra micronized palmitoylethanolamide/luteolin composite mitigates clinical score and disease-relevant molecular markers in a mouse model of experimental autoimmune encephalomyelitis’, Journal of Neuroinflammation,

(2) Maria Beatrice Passavanti, Aniello Alfieri, Maria Caterina Pace, Vincenzo Pota, Pasquale Sansone, Giacomo Piccinno, Manlio Barbarisi, Caterina Aurilio & Marco Fiore (2019) ‘ Clinical applications of palmitoylethanolamide in pain management: protocol for a scoping review’, Systematic Reviews volume,

(3) Eleonora Palma, Jorge Mauricio Reyes-Ruiz, Diego Lopergolo, Cristina Roseti, Cristina Bertollini, Gabriele Ruffolo Pierangelo Cifelli, Emanuela Onesti, Cristina Limatola, Ricardo Miledi, Maurizio Inghillerid (2016) ‘Acetylcholine receptors from human muscle as pharmacological targets for ALS therapy’, Proc Natl Acad Sci U S A.,

(4) Di Cesare Mannelli, G. D’Agostino, A. Pacini, R. Russo, M. Zanardelli, C. Ghelardini, A. Calignano (2013) ‘Palmitoylethanolamide Is a Disease-Modifying Agent in Peripheral Neuropathy: Pain Relief and Neuroprotection Share a PPAR-Alpha-Mediated Mechanism’, Mediators Inflamm.

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