Why We Need Nicotinamide Riboside Chloride

The cosmetic industry is a billion-dollar industry, primarily because human beings are obsessed with the way they look. This is also the key factor why the research around anti-ageing ingredients and products has made such incredible advances in such a short time. Global conglomerates understand that there is money to made from individuals’ desire to stay forever young and thus, have teams in place, devoting days and weeks to find ingredients and products that can enhance skin vitality. Nicotinamide Riboside or Niagen was discovered as a result of this unabated search for anti-ageing products. While most anti-ageing products minimize signs of ageing from the skin, Niagen minimizes signs of ageing within the body. Nicotinamide Riboside or Niagen is the crystal form of Nicotinamide Riboside Chloride and once within the body, it converts into NAD+, which is responsible for healthy ageing as well as various other crucial functions. 

In this article, we cover all aspects of this wonder compound, including its benefits, side-effects and appropriate dosage.


What is Nicotinamide Riboside Chloride?

Nicotinamide Riboside Chloride or Niagen is the crystal form of Nicotinamide Riboside, which is an NAD+ precursor vitamin. While Nicotinamide Riboside weighs 255.25 g/mol, Nicotinamide Riboside Chloride weighs 290.70 g/mol and 100 mg of Nicotinamide Riboside Chloride provides 88 mg of Nicotinamide Riboside. NR is considered safe to be used in foods.

Though Nicotinamide Riboside is a form of Vitamin B3, its various properties make it quite different from many of the other members of the vitamin B3 group, such as nicotinamide and niacin. While Niacin causes the skin to flush by activating the GPR109A G-protein coupled receptor, Nicotinamide Riboside does not react at all with this receptor and therefore, does not even cause skin flushing, even when consumed in high dosage amounts of 2000 mg per day. Further, experiments conducted on mice revealed that Nicotinamide Riboside is the NAD+ precursor that led to the highest spike in Nicotinamide Adenine Dinucleotide or NAD+ within the body. 

Nicotinamide Riboside occurs naturally in the human diet and once within the body, it changes to NAD+, which the body needs for a variety of functions. For instance, scientific research has proven that Nicotinamide Riboside Chloride or NAD+ provided by NR improves mitochondrial function as well as insulin sensitivity by activating the sirtuin family of enzymes, which is responsible for regulating oxidative metabolism within the body.

So far, five studies have been conducted to study the safety and efficacy of Nicotinamide Riboside and all of these studies have found the compound to be safe for human usage.


Nicotinamide Riboside Chloride Benefits

Before we discuss the benefits of Nicotinamide Riboside Chloride, it is important to clarify that since Nicotinamide Riboside Chloride is the salt from which Nicotinamide Riboside is obtained, the benefits of Nicotinamide Riboside Chloride are same as the benefits of Nicotinamide Riboside.


Nicotinamide Riboside Chloride Promotes Healthy Ageing

The NAD+ activated by Nicotinamide Riboside Chloride within the body activates specific enzymes linked with healthy ageing. One such enzyme is sirtuins, which has been linked with overall improved life and lifespan in animals. Scientific studies have proved that sirtuins improve life quality and longevity by reducing inflammation, enhancing the benefits associated with calorie restriction and repairing the damaged DNA. The NAD+ activated by Nicotinamide Riboside Chloride also activates Poly polymerases which are known to repair damaged DNA. Further, several scientific studies have linked the activity of polymerases with an enhanced lifespan. 


It Reduces One’s Chances of Developing Heart Diseases

Ageing also increases one’s chances of developing heart diseases. As people advance in age, their blood vessels become thicker and rigid, which in turn, leads to increased blood pressure. When the blood pressure within the vessels increases, the heart has to work doubly harder to pump the blood, which leads to various heart diseases. The NAD+ provided by Nicotinamide Riboside Chloride reverses the age-related changes caused to blood vessels. There is ample scientific evidence to prove that Nicotinamide Adenine Dinucleotide or NAD+ does not only reduce blood vessel stiffness but also regulates the systolic blood pressure.


Nicotinamide Riboside Chloride Also Provides Protection to Brain Cells

Nicotinamide Riboside protects brain cells. A study conducted on mice revealed that NR-induced production of NAD+ increased the production of PGC-1 alpha protein by up to 50%. The PGC-1 alpha protein helps protect brain cells against oxidative stress and also improves mitochondrial function. It is, thus, that NR consumption in humans protects against age-induced brain diseases, such as Alzheimer’s and Parkinson’s. One particular research study studied the effect of NAD+ levels on people suffering from Parkinson’s. The study concluded that NAD+ improved mitochondrial function in stem cells.


Other Key Benefits of Nicotinamide Riboside Chloride

Other than the benefits discussed above, here are a few more additional benefits associated with Nicotinamide Riboside Chloride.

  • NR is known to enhance muscle strength, function and endurance and therefore, NR consumption is linked with better athletic performance.
  • As discussed above, NR-induced production of NAD+ repairs damaged DNA and provides protection against oxidative stress. This, in turn, reduces one’s chances of developing cancer.
  • A study analyzed the effect of Nicotinamide Riboside on metabolism in mice. The study concluded that NR increased metabolism in mice. Though more scientific proof is needed regarding this, many scientists believe that Nicotinamide Riboside would have a similar effect on humans and therefore, should be helpful with weight loss.

Nicotinamide Riboside Chloride

Nicotinamide Riboside Chloride Dosage

The five studies conducted so far have established that Nicotinamide Riboside is safe for human usage. However, these studies have established the safe Nicotinamide Riboside Chloride dosage limit for human beings between 1,000 to 2,000 mg per day. However, it must be kept in mind that all of the studies that analyzed the safety of Nicotinamide Riboside had a very small sample size and thus, more research is needed in this area. 

The primary purpose of Nicotinamide Riboside Chloride is to essentially provide Nicotinamide Riboside Chloride or Niagen to the body. Niagen or NR is usually available in two forms: tablets and capsules. Many Nicotinamide Riboside supplement manufacturers combine NR with other chemicals, such as Pterostilbene. In any case, to be safe, most supplement manufacturers recommend keeping the daily intake of NR between 250 to 300 mg per day.


Is Nicotinamide Riboside Chloride Safe?

The several studies conducted so far have found Nicotinamide Riboside consumption in the range 1000 to 2000 mg per day safe for human usage. However, since more concrete studies are needed in this area, Nicotinamide Riboside manufacturers recommend keeping one’s daily intake of NR under 250-300 mg per day.

Though Nicotinamide Riboside or Nicotinamide Riboside Chloride consumption is safe, it can lead to side-effects such as nausea, headaches, indigestion, fatigue and diarrhoea. If you experience any of these symptoms while taking an NR supplement, immediately consult your doctor. Moreover, since there isn’t enough evidence regarding the effect of Nicotinamide Riboside on pregnant and breastfeeding women, this group should steer away from the use of Nicotinamide Riboside supplements. 


Nicotinamide Riboside Chloride Supplement

If you are looking for a vegetarian Nicotinamide Riboside Chloride supplement, we recommend Tru Niagen Nicotinamide Riboside supplement. This supplement uses NIAGEN, the company’s patented NR product. The manufacturing company deals only with Nicotinamide Riboside supplements and therefore, one can rest assured that the supplements created by the company are of very high quality. The Tru Niagen Nicotinamide Riboside supplement comes in easy-to-consume capsules, which are quite easy-to-swallow. Users are required to take only one capsule per day.

However, if you are looking for a gluten, egg, BPA, nuts, preservatives and dairy-free product, we recommend putting your money in the Thorne ResveraCel Nicotinamide Riboside supplement. This supplement combines NR with flavonoids. Together, these two enhance sirtuin activity. More importantly, Thorne ResveraCel claims that it does four rounds of testing on each of its supplement and thus, the company’s supplements are perfectly safe. Further, these supplements are produced in a cGMP certified facility in the United States and a TGA certified facility in Australia.

Nicotinamide Riboside Chloride

Where to Buy Nicotinamide Riboside Chloride Powder in Bulk?

The demand for Nicotinamide Riboside supplements has increased considerably over the last few years, primarily because Nicotinamide Riboside has many advantages. If you are looking to foray into the Nicotinamide Riboside supplements market, the first thing you must do is find yourself a trustworthy and reliable raw materials supplier. Where to buy Nicotinamide Riboside Chloride powder in bulk? The answer is Cofttek.

Cofttek is a raw materials supplier that came into existence in 2008 and in only about a decade, the company has established its presence in several countries. Other than producing reliable products, the company is also focussed on making advances in the field of biotechnology, chemical technology and chemical testing. The company is also committed to quality research, which gives it an edge over other suppliers in the market. The Nicotinamide Riboside Chloride powder  provided by the company comes in batches of 25 kgs and can be trusted for quality. Moreover, the company has excellent sales and customer support team which will take care of all your needs and enquiries in real-time. This, if you want to buy Nicotinamide Riboside Chloride powder in bulk, trust only Cofttek. 


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  2. Carlijn M E Remie, Kay H M Roumans, Michiel P B Moonen, Niels J Connell, Bas Havekes, Julian Mevenkamp, Lucas Lindeboom, Vera H W de Wit, Tineke van de Weijer, Suzanne A B M Aarts, Esther Lutgens, Bauke V Schomakers, Hyung L Elfrink, Rubén Zapata-Pérez, Riekelt H Houtkooper, Johan Auwerx, Joris Hoeks, Vera B Schrauwen-Hinderling, Esther Phielix, Patrick Schrauwen, Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans, The American Journal of Clinical Nutrition, Volume 112, Issue 2, August 2020, Pages 413–426
  3. Elhassan, Y. S., Kluckova, K., Fletcher, R. S., Schmidt, M. S., Garten, A., Doig, C. L., Cartwright, D. M., Oakey, L., Burley, C. V., Jenkinson, N., Wilson, M., Lucas, S., Akerman, I., Seabright, A., Lai, Y. C., Tennant, D. A., Nightingale, P., Wallis, G. A., Manolopoulos, K. N., Brenner, C., … Lavery, G. G. (2019). Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures. Cell reports28(7), 1717–1728.e6.
  4. Nicotinamide Riboside Chloride powder