1.Why We Need Nicotinamide Mononucleotide(NMN)
Aging is time-related and time-assisted retrogression of human bodily functions. Though aging is inevitable and unavoidable, scientists have devoted years to understanding how this process can be delayed and controlled. This continued research has led to the discovery of several substances and compounds with anti-aging properties that can be converted into anti-aging supplements. One such compound with significant anti-aging properties that has scientists feeling fascinated is NMN or Nicotinamide Mononucleotide. In this article, we discuss everything there is to know about NMN as well as the best anti-aging supplement of nicotinamide mononucleotide in 2020.
2. What is Nicotinamide Mononucleotide(NMN)?
Nicotinamide Mononucleotide(1094-61-7) or NMN is a nucleotide that exists naturally within most of the foods we eat. It is found in avocado, broccoli, cucumber, cabbage, edamame, and tomatoes. However, the quantity of NMN supplied by these foods is not enough to sustain key bodily functions and thus, people are often advised to take NMN supplements. But, why is NMN so crucial for the body?
Nicotinamide Mononucleotide or NMN is a precursor to Nicotinamide Adenine Dinucleotide or NAD+. In simple words, NMN is the compound that converts into NAD+ through a series of chemical reactions that happen inside the cells. NAD+, on the other hand, is considered crucial for the body as it performs several key tasks, including balancing the body’s circadian rhythm, breaking down nutrients to release cellular energy, and facilitating key enzymatic reactions, some of which delay aging. Unfortunately, though NAD+ is found within every cell of the body, its production decreases with age. More importantly, there are no foods that a person can consume to increase the production of NAD+ within the body. It is, thus, that the body requires an NAD+ precursor that transforms into NAD+ within the cell, thereby balancing out its decline within the body. This is where the use of NMN supplements comes into play.
3. Nicotinamide Mononucleotide(NMN) Uses
Until a few years ago, all studies related to NMN uses were performed on animals and while these studies showed promising results, these results were not enough to establish the advantages of NMN use in human beings. In 2016, a study was conducted to analyze the safety of NMN consumption and its time course in human blood. The study delivered promising results. Post that, another study was conducted in 2016 to study the effect of NMN consumption in 50 older women suffering from high BMI, blood glucose, and blood triglycerides. The study was successful. However, since the study ground was restricted to women of a certain age, scientists believed that more proof was required to establish whether NMN consumption was safe for human beings.
Therefore, more recently, in 2019, a study was conducted at the Clinical Trial Unit of the Keio University School of Medicine. The subject of the study were 10 men aged between 40 and 60. These men were administered doses ranging from 100 mg to 500 mg. The study concluded that NMN is well-tolerated by human beings and is safe to consume as long as its consumption is well-regulated. This study was crucial as it was the first NMN study conducted on humans to study the effect of NMN on overall human health. As soon as it was established that NMN consumption is safe, manufacturers started bombarding the market with NMN supplements, which have become quite common these days.
4.Nicotinamide Mononucleotide (NMN)Dosage
While studies have established that Nicotinamide Mononucleotide or NMN is safe for human use, research is still being conducted to figure out the most effective dosage and frequency of NMN dosage in humans. However, studies that have been conducted so far have established that a dosage of up to 500 mg per day is safe for men. These days, Nicotinamide Mononucleotide is available in different forms, including pills and powder. NMN supplement suppliers claim that oral supplements are quite effective at boosting NAD+ production in the body. These claims are based on the fact that Slc12a8, a nicotinamide nucleotide transporter, helps with the absorption of NMN in the gut.
5.Nicotinamide Mononucleotide (NMN) Benefits
In this section, we discuss the potential benefits linked with Nicotinamide Mononucleotide or NMN benefits.
●NMN Slows Down Aging
One of the biggest advantages of NMN is that it slows down the aging process. A few years ago David Sinclair, the popular Australian Biologist and professor of Genetics, provided proof that NAD+ slows down aging as well as the onset of age-related diseases in humans. However, the production of NAD+ reduces with age. Thus, as people age, the need for an NAD+ precursor increases within their bodies. This is where NMN comes into play: NMN enters the cells and undergoes several chemical transformations before it turns into NAD+ and slows down age-induced processes.
●People Suffering from Diabetes Can Benefit from Its Consumption
A study was conducted to study how NMN oral supplementation helped with diet and age-related diabetes in mice. The study revealed that the mice given oral NMN supplementation exhibited increased sensitivity to insulin as well as its increased secretion. This study provided some indication that Nicotinamide Mononucleotide or NMN oral supplementation can help people suffering from diabetes.
●NMN Consumption Is Also Linked with Improved Heart Health
Another study was performed to study how NMN supplementation affected heart health in mice The study revealed that NMN not only reversed age-related blood vessel and capillary damage in mice but also led to improved blood flow. What was most surprising was the fact that in mice given NMN oral supplementation, the eruption of new blood vessels was observed. More recently, another study was conducted to study the effect of NMN on hearth health in mice and this study too revealed similar results. These studies have provided enough proof to researchers to believe that NMN consumption also promotes heart health in human beings.
●People with Alzheimer’s Can Benefit from NMN Use
In people suffering from Alzheimer’s disease, the NAD levels go down significantly. Thus, when people suffering from Alzheimer’s consume NMN, the body reacts by increasing the amount of NAD+, which in turn, leads to increased motor control, increased SIRT3 gene activity, improved memory, and reduced neuroinflammation. Thus, people suffering from Alzheimer’s can benefit from consuming NMN.
●NMN Also Improves Kidney Function
Oral NMN supplementation is linked with improved kidney function. This is because NMN increases the production of NAD+ and SIRT1, both of which are linked with enhanced kidney function.
6.Is Nicotinamide Mononucleotide(NMN) Safe?
Over the years, several studies have been conducted to study whether NMN consumption in humans is safe or not. These studies have, time and again, revelated that Nicotinamide Mononucleotide consumption is absolutely safe when its dosage is restricted. In general, men are advised to stick to a daily dose of less than 500 mg. However, it must be highlighted that the FDA has not yet approved NMN as a safe drug. Thus, if you have any allergies or medical issues, it’s best you consult with your doctor before starting any NMN supplements.
7.The Best Anti-Aging Supplement of Nicotinamide Mononucleotide
After a 2019-study concluded that Nicotinamide Mononucleotide is safe for human consumption if its consumption is restricted to the prescribed limit, several manufacturing companies have entered the market with their offerings. This overabundance of choice has left buyers confused about which Nictonimade Mononucleotide(NMN) supplement is best for them. In our opinion, the best anti-aging supplement of Nicotinamide Mononucleotide (NMN) in 2020 is the Cofttek company.
Cofttek is an A+ rated company that has been in the market for almost 12 years and has developed a loyal follower base during this time. The NMN powder supplied by the company is triple lab-tested, pharmaceutical-grade NMN sourced from the same companies that had supplied NMN for the various significant human clinical trials that have taken place over the years. The NMN powder supplied by Cofttek facilitates its easy absorption into the body, thereby increasing the bioavailability of the product as well as its physiological functions. More importantly, this powder comes in bulk and you can store it for three months. All in all, this is one of the best supplements currently available in the market with high user rating and it comes from a company that has delivered reliable and effective products year after year.
8.Where to Buy Nicotinamide Mononucleotide(NMN) Powder in Bulk?
If you are looking to buy Nicotinamide Mononucleotide(NMN) powder in bulk, the best place to buy NMN powder is cofttek.com. Cofttek is a high-tech pharmaceutical enterprise that has been providing innovative and high-quality products since 2008. The company boasts of an impressive R&D team with experienced individuals committed to the development of competitive products. Cofttek has partners and supplies its products to pharmaceutical companies in China, Europe, India, and North America. The β-Nicotinamide Mononucleotide supplied by Cofttek is of very high-quality and completely safe for human consumption. More importantly, the company supplies this powder in bulk, i.e. in units of 25kgs. Thus, if you are looking to buy this powder in bulk, Cofttek is the company you should contact — they are the best Nicotinamide Mononucleotide (NMN) powder supplier in the market.
(1) Yao, Z., et al. (2017). Nicotinamide Mononucleotide Inhibits JNK Activation to Reverse Alzheimer Disease.
(2) Yoshino, J., et al. (2011). Nicotinamide Mononucleotide, a Key NAD(+) Intermediate, Treats the Pathophysiology of Diet and Age-Induced Diabetes in Mice. Cell Metabolism.
(3) Yamamoto, T., et al. (2014). Nicotinamide Mononucleotide, an Intermediate of NAD+ Synthesis, Protects the Heart from Ischemia and Reperfusion.
(4) Wang, Y., et al. (2018). NAD+ Supplementation Normalizes Key Alzheimer’s Features and DNA Damage Responses in a New AD Mouse Model with Introduced DNA Repair Deficiency.
(5) Keisuke, O., et al. (2019). Implications of Altered NAD Metabolism in Metabolic Disorders. Journal of Biomedical Sciences.