FREE RADICAL THEORY
FREE RADICALS & DISEASESNormally, free radicals are necessary for bodies, but excessive free radicals can cause the imbalance of physiological function, then lead to oxidative stress evolving in various diseases ( literatures indicate that free radicals are the source of various diseases).
ANTIOXIDANTOur bodies cannot operate without oxygen, and once a large number of free radicals increased, the body under oxidative stress will cause the repair system to fail in removing excessive free radicals. In special cases, the body need replenish antioxidants in vitro to remove excessive free radicals.
DEVELOPMENT OF ANTIOXIDANTS
L-ERGOTHIONEINE –A NEW TYPE OF NATURAL ANTIOXIDANT
EGT is a natural chiral amino-acid antioxidant biosynthesized in certain bacteria and fungi. It is an important bioactive compound which has been used as a radical scavenger, an ultraviolet ray filter, a regulator of oxidation-reduction reactions and cellular bioenergetics, and a physiological cytoprotector, etc.
With advantages of multi-functions, EGT stands out among many other antioxidants.
With advantages of multi-functions, EGT stands out among many other antioxidants.Advantages (compared with glutathione, cysteine etc.):
——EGT is easier to accumulate in cells and the concentration is more stable than other antioxidants.
——EGT is more effective on reducing cell death caused by pyrogallol.
——EGT mainly scavenges ROS to prevent oxidation, while glutathione and others scavenge free radicals, that is, other antioxidants scavenge oxidation products.(1)Oleoylethanolamide (oea) –the magical wand of your life
COMPARISON OF ANTIOXIDATION
Results: EGT was the most active scavenger of free radicals as compared to classic antioxidants as GSH, uric acid and trolox. In particular, the highest antioxidant capacity exhibited by EGT vs. peroxyl radicals resulted 25% higher than the value obtained with the reference antioxidant trolox. The scavenging capacity of EGT towards hydroxyl radicals was 60% higher, as compared to uric acid,which represent the reference antioxidant vs. hydroxyl radicals. Finally, EGT showed the highest antioxidant activity also towards peroxynitrite, with a scavenging capacity 10% higher than that of uric acid.
EGT also has effects on regulating intracellular energy,
improving the survival rate of sperm,
protecting the liver from injury,
developmental defects and cataract.
NECESSITY OF DEVELOPMENT
① EGT HAS BEEN WIDELY FOUND IN PLANTS AND ANIMALS
5-10mg per unit for an adult and 2-3 units continuous intake is essential in your daily diet.Source: Li Yiqun, Zhou Nianbo. Biology Functions and Applications of EGT [J]. Food Engineering，2010，9（3）：26-28.
Intakes are listed as follows:
|Children (3-11 years)||≤l 0 mg/day|
|Youth (11-21 years）||≤30 mg/day|
|Adults(21-80 years)||≤30 mg/day|
|Note：1. Dosages for children and adults（3 -80 years old） 2.Use for pregnant or lactating women is not recommended.|
Data source: Tetrahedron when applying for US NDIData suggest: 10.5mg/g for OXIS’s ADI (Acceptable Daily Intake).
EXTRACTION & APPLICATION
Comparison of EGT Extraction Methods
EGT has broad applications in cosmetics, functional foods, pharmaceuticals, therapeutics, biomedicine, and so on.
(3)OTHER AVAILABLE APPLICATIONS
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Dr. Zeng Zhaosen
Co-founder, the company’s core administration leadership; PhD received from Fudan University in organic chemistry. More than nine years of experience in organic synthesis field of medicinal chemistry. Rich experience in combinatorial chemistry, medicinal chemistry and custom synthesis and project management.Reach me Now