What is Anandamide(AEA)

Anandamide(AEA), also known as the bliss molecule, or N-arachidonoylethanolamine (AEA), is a fatty acid neurotransmitter. The name Anadamida (AEA) is derived from the Sanskrit of Joy “Ananda.” Raphael Mechoulam coined the term. How, along with his two assistants, W. A. Devane and Lumír Hanuš, first discovered “Anandamide” in 1992. Anandamide (AEA) is a great fix for a lot of our physical and mental problems.

What is Cannabidiol (CBD)?

Cannabidiol (CBD) is the second most abundant active compounds known as cannabinoids found in the cannabis sativa (marijuana or hemp). Tetrahydrocannabinol (THC) is the most prevalent and also the most psychoactive cannabinoid found in the cannabis plant. THC is associated with getting a “high” sensation.
However, CBD is not psychoactive and is derived from the hemp plant which contains low amounts of THC. This property has made CBD gain popularity in the health and wellness sector.
Cannabidiol (CBD) oil on the other hand is derived from the cannabis plant by adding the extracted CBD to carrier oil such as hemp seed oil or coconut oil.

Anandamide & Cannabidiol FAQ

What is Anandamide?

Anandamide, also known as N-arachidonoylethanolamine, is a fatty acid neurotransmitter derived from the non-oxidative metabolism of eicosatetraenoic acid, an essential omega-6 fatty acid. The name is taken from the Sanskrit word ananda, which means “joy, bliss, delight”, and amide.

Is anandamide a hormone?

The research provides the first link between oxytocin — dubbed the “love hormone” — and anandamide, which has been called the “bliss molecule” for its role in activating cannabinoid receptors in brain cells to heighten motivation and happiness.

Is anandamide excitatory or inhibitory?

In conclusion, cannabinoid receptors of the CB1 type as well as their endogeneous ligand, anandamide, are involved in the control of neuronal excitability, thus reducing excitatory neurotransmission at a presynaptic site, a mechanism which might be involved in the prevention of excessive excitability leading to.

What are the two most researched endocannabinoids that the body naturally produces?

Researchers speculate there may be a third cannabinoid receptor waiting to be discovered. Endocannabinoids are the substances our bodies naturally make to stimulate these receptors. The two most well understood of these molecules are called anandamide and 2-arachidonoylglycerol (2-AG).

Does the human body have a cannabinoid system?

The endogenous cannabinoid system—named for the plant that led to its discovery—is one of the most important physiologic systems involved in establishing and maintaining human health. Endocannabinoids and their receptors are found throughout the body: in the brain, organs, connective tissues, glands, and immune cells.

What was the first cannabinoid discovered?

In 1992, Mechoulam’s lab isolated the first endocannabinoid: a molecule that was ultimately classified as a CB1 receptor partial agonist. It was identified as arachidonoyl ethanolamide and named anandamide.

Is anandamide a chocolate?

THC, however, is not found in chocolate. Instead, another chemical, a neurotransmitter called anandamide, has been isolated in chocolate. Interestingly, anandamide is also produced naturally in the brain.

Is chocolate a cannabinoid?

Anandamide is called an endocannabinoid because it is made by our body and mimics the cannabinoids found in the marijuana plant. Thus, an ingredient in chocolate and an ingredient in the marijuana plant are both capable of stimulating our brain’s own marijuana neurotransmitter system.

Does chocolate have theobromine?

Theobromine is the primary alkaloid found in cocoa and chocolate. Cocoa powder can vary in the amount of theobromine, from 2% theobromine, up to higher levels around 10%. … There are usually higher concentrations in dark than in milk chocolate.

What are the most common cannabinoids?

The two main cannabinoids are delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). The most commonly known of the two is delta-9-tetrahydrocannabinol (THC), which is the chemical that is responsible for the psychoactive effects of cannabis.

What is the bliss molecule?

Anandamide is a little-known brain chemical that’s been called the “bliss molecule” for the role it plays in producing feelings of happiness. … It works by binding to the same receptors in the brain as the main psychoactive compound in marijuana.

Is anandamide a drug?

Anandamide, an endogenous ligand for brain cannabinoid CB1 receptors, produces many behavioral effects similar to those of Δ9-tetrahydrocannabinol (THC), the main psychoactive ingredient in marijuana.

Does the human body produce cannabinoids?

Endocannabinoids. Endocannabinoids, also called endogenous cannabinoids, are molecules made by your body. They’re similar to cannabinoids, but they’re produced by your body.

Does CBD increase dopamine?

CBD also stimulates the adenosine receptor to encourage the release of glutamate and dopamine neurotransmitters. Through its interaction with dopamine receptors, it helps to raise dopamine levels and regulate cognition, motivation, and reward-seeking behaviors.

Does Indica increase dopamine?

decreases acute pain. increases appetite. increases dopamine (a neurotransmitter that helps control the brain’s reward and pleasure centers) for night time use.

What type of drug is chocolate?

In addition to sugar, chocolate also has two other neuroactive drugs, caffeine and theobromine. Chocolate not only stimulates the opiate receptors in our brains, it also causes a release of neurochemicals in the brain’s pleasure centers.

What does anandamide do in the body?

Our bodies create anandamide on-demand, to be used when needed to maintain homeostasis. Anandamide does this by helping to regulate inflammation and neuron signaling. As it is created, it binds primarily with our cannabinoid receptors CB1 and CB2 just as a cannabinoids such as THC would upon ingestion.

What is the cannabinoid receptor system?

Cannabinoid receptors, located throughout the body, are part of the endocannabinoid system, which is involved in a variety of physiological processes including appetite, pain-sensation, mood, and memory. Cannabinoid receptors are of a class of cell membrane receptors in the G protein-coupled receptor superfamily.

What are the different functional groups present in anandamide?

Anandamide functional groups include amides, esters, and ethers of long-chain polyunsaturated fatty acids, and structurally share critical pharmacophores with D-9-tetrahydrocannabinol (THC).

How do you increase anandamide levels naturally?

Eat a diet rich in these fruits and inhibit your FAAH production which increases your anandamide levels! Chocolate is another food that can help boost anandamide. It contains a compound known as ethylenediamine which inhibits FAAH production. Keep these three foods in mind the next time you head into the supermarket.

Does chocolate contain anandamide?

THC, however, is not found in chocolate. Instead, another chemical, a neurotransmitter called anandamide, has been isolated in chocolate. Interestingly, anandamide is also produced naturally in the brain.

Is chocolate a drug?

Chocolate has a significant amount of sugar. In addition to sugar, chocolate also has two other neuroactive drugs, caffeine and theobromine. Chocolate not only stimulates the opiate receptors in our brains, it also causes a release of neurochemicals in the brain’s pleasure centers.

What is the drug in chocolate?

Theobromine is the primary alkaloid found in cocoa and chocolate.

Which chemical is present in chocolate?

Theobromine, formerly known as xantheose, is a bitter alkaloid of the cacao plant, with the chemical formula C7H8N4O2. It is found in chocolate, as well as in a number of other foods, including the leaves of the tea plant, and the kola nut.

Does chocolate increase serotonin?

However, because chocolate contains tryptophan, the resulting increase in serotonin can help explain why one might feel happier, calmer, or less anxious after eating a piece of their chocolate cake (Serotonin).

What is anandamide responsible for?

Anandamide plays a role in the regulation of feeding behavior, and the neural generation of motivation and pleasure. Anandamide injected directly into the forebrain reward-related brain structure nucleus accumbens enhances the pleasurable responses of rats to a rewarding sucrose taste, and enhances food intake as well.

Is CBD an antioxidant?

THC and CBD are powerful antioxidants—more powerful than vitamin C and E. In fact, the U.S. Government Patent 1999/008769 is specifically for the neuroprotectant and antioxidant properties of cannabinoids.

What does the FAAH enzyme do?

Fatty acid amide hydrolase (FAAH) is a mammalian integral membrane enzyme that degrades the fatty acid amide family of endogenous signaling lipids, which includes the endogenous cannabinoid anandamide and the sleep-inducing substance oleamide.

How does CBD affect anandamide?

Biochemical studies indicate that cannabidiol may enhance endogenous anandamide signaling indirectly, by inhibiting the intracellular degradation of anandamide catalyzed by the enzyme fatty acid amide hydrolase (FAAH).

What does cannabinoid mean?

The word cannabinoid refers to every chemical substance, regardless of structure or origin, that joins the cannabinoid receptors of the body and brain and that have similar effects to those produced by the Cannabis Sativa plant. … The two main cannabinoids are delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD).

What is the endocannabinoid system and what does it do?

The human body contains a specialized system called the endocannabinoid system (ECS), which is involved in regulating a variety of functions including sleep, appetite, pain and immune system response.

Does the body have cannabinoid receptors?

Cannabinoid receptors, located throughout the body, are part of the endocannabinoid system, which is involved in a variety of physiological processes including appetite, pain-sensation, mood, and memory. … In 2007, the binding of several cannabinoids to the G protein-coupled receptor GPR55 in the brain was described.

Does CBD increase anandamide?

In terms of the cannabinoid receptor-dependent effects of CBD on learned fear regulation described above, CBD increases anandamide levels by inhibiting its transporter-mediated reuptake and degradation by FAAH.

Which cannabinoid is used for anxiety?

With a lower dose of THC and a moderate dose of CBD, Harlequin’s cannabinoid profile is well-suited for anxiety fighters who don’t mind gentle euphoria. Its most abundant terpene is myrcene, which is believed to have a relaxing effect and has been used throughout history as a sleep aid.

Does CBD help anxiety?

CBD is commonly used to address anxiety, and for patients who suffer through the misery of insomnia, studies suggest that CBD may help with both falling asleep and staying asleep. CBD may offer an option for treating different types of chronic pain.

Does alcohol help anxiety?

Alcohol is a sedative and a depressant that affects the central nervous system. At first, drinking can reduce fears and take your mind off of your troubles. It can help you feel less shy, give you a boost in mood, and make you feel generally relaxed.

How do I get diagnosed with anxiety?

To diagnose an anxiety disorder, a doctor performs a physical exam, asks about your symptoms, and recommends a blood test, which helps the doctor determine if another condition, such as hypothyroidism, may be causing your symptoms. The doctor may also ask about any medications you are taking.

What drugs should not be taken with CBD?

  • Antidepressants (such as fluoxetine, or Prozac)
  • Medications that can cause drowsiness (antipsychotics, benzodiazepines)
  • Macrolide antibiotics (erythromycin, clarithromycin)
  • Heart medications (some calcium channel blockers)

Does CBD release dopamine?

CBD also stimulates the adenosine receptor to encourage the release of glutamate and dopamine neurotransmitters. Through its interaction with dopamine receptors, it helps to raise dopamine levels and regulate cognition, motivation, and reward-seeking behaviors.

What low dopamine feels like?

Some signs and symptoms of conditions related to a dopamine deficiency include: muscle cramps, spasms, or tremors. aches and pains. stiffness in the muscles.

Does caffeine raise dopamine levels?

Caffeine, the most widely consumed psychoactive substance in the world, is used to promote wakefulness and enhance alertness. Like other wake-promoting drugs (stimulants and modafinil), caffeine enhances dopamine (DA) signaling in the brain, which it does predominantly by antagonizing adenosine A2A receptors (A2AR).

What is the fastest way to increase dopamine?

  • Eat Lots of Protein
  • Eat Less Saturated Fat
  • Consume Probiotics
  • Eat Velvet Beans
  • Exercise Often
  • Get Enough Sleep
  • Listen to Music
  • Meditate
  • Get Enough Sunlight
  • Consider Supplements

Does CBD help anxiety?

CBD is commonly used to address anxiety, and for patients who suffer through the misery of insomnia, studies suggest that CBD may help with both falling asleep and staying asleep. CBD may offer an option for treating different types of chronic pain.

Does CBD raise serotonin?

CBD doesn’t necessarily boost serotonin levels, but it may affect how your brain’s chemical receptors respond to the serotonin that’s already in your system. A 2014 animal study found that CBD’s effect on these receptors in the brain produced both antidepressant and anti-anxiety effects.

Can CBD help your brain?

Researchers believe that CBD’s ability to act on the endocannabinoid system and other brain signaling systems may provide benefits for those with neurological disorders. In fact, one of the most studied uses for CBD is in treating neurological disorders like epilepsy and multiple sclerosis.

How can I raise serotonin levels?

  • Food
  • Exercise
  • Bright light
  • Supplements
  • Massage
  • Mood induction

What is the best CBD oil to buy for weight loss?

Anandamide is a lipid mediator that acts as an endogenous ligand of CB1 receptors. These receptors are also the primary molecular target responsible for the pharmacological effects of Δ9-tetrahydrocannabinol, the psychoactive ingredient in Cannabis sativa.

How do you make anandamide?

It is synthesized from N-arachidonoyl phosphatidylethanolamine by multiple pathways. It is degraded primarily by the fatty acid amide hydrolase (FAAH) enzyme, which converts anandamide into ethanolamine and arachidonic acid.

Does the human body produce CBD?

What you may not realise, however, is that this follows from the fact that the human body actually produces its own endogenous cannabinoids: natural equivalents of the compounds found in the cannabis plant, such as THC (tetrahydrocannabinol) and CBD (cannabidiol).

Is CBD really that great?

There’s no evidence, for example, that CBD cures cancer. There is moderate evidence that CBD can improve sleep disorders, fibromyalgia pain, muscle spasticity related to multiple sclerosis, and anxiety. “The most benefit I have seen as a physician is in treating sleep disorders, anxiety, and pain,” says Dr. Levy.

Are CBD products safe?

CBD use also carries some risks. Though it’s often well-tolerated, CBD can cause side effects, such as dry mouth, diarrhea, reduced appetite, drowsiness and fatigue. CBD can also interact with other medications you’re taking, such as blood thinners.

What does CBD do to the brain?

These qualities are linked to CBD’s ability to act on the brain’s receptors for serotonin, a neurotransmitter that regulates mood and social behavior. Summary Using CBD has been shown to reduce anxiety and depression in both human and animal studies.

How fast does CBD leave the system?

CBD typically stays in your system for 2 to 5 days, but that range doesn’t apply to everyone. For some, CBD can stay in their system for weeks.

Where is anandamide found?

Anandamide is synthesized enzymatically in the areas of the brain that are important in memory, thought processes and control of movement. Research suggests that anandamide plays a role in the making and breaking of short-term connections between nerve cells, and this is related to learning and memory.

Is anandamide a cannabinoid?

Also called N-arachidonoylethanolamine (AEA), anandamide interacts with the body’s CB receptors similarly to cannabinoids like THC. It’s a neurotransmitter and cannabinoid-receptor binding agent that functions as a signal messenger for CB receptors located in the body.

How Anandamide (AEA) Works

Anandamide(AEA) is derived from the non-oxidative metabolism of eicosatetraenoic acid. Anandamide (AEA) is a lipid mediator and functions as an endogenous ligand of CB1 receptors and modulates its reward circuitry. It is an important neurotransmitter in the endocannabinoid system, named after Cannabis. It helps regulate the flow of neurochemical systems to keep your body and mind functioning smoothly. It is found that the Anandamide structure is similar to tetrahydrocannabinol (THC), the main psychotic component of Cannabis. Thus Anandamide changes mood simulates what popularly is known as Cannabis high.

It is naturally produced in our body as per the brain’s instruction by a condensation reaction in neurons. The condensation reaction controlled by calcium ion and cyclic monophosphate adenosine takes place between arachidonic acid and ethanolamine.

Anandamide increases happiness by interacting with cannabinoid receptors in the nervous and peripheral nervous system, CB1 and CB2. CB1 receptors target Motor activity (movement) and coordination, Thinking, Appetite, Short terms memory, Pain perception, and Immunity. At the same time, CB2 receptors target major organs like the Liver, Gut, kidney, Pancreas, Adipose tissues, Skeletal muscle, Bone, Eye, Tumours, Reproductive system, Immune system, Respiratory tract, skin, Central Nervous system, and Cardiovascular system.

In our body, N-arachidonoylethanolamine breaks down into fatty acid amide hydrolase (FAAH) enzyme and produces arachidonic acid and ethanolamine. If FAAH’sFAAH’s action can be slowed down, we can reap Anandamide’sAnandamide’s benefits for a longer period.

Anandamide (AEA)
Anandamide (AEA)

How does Cannabidiol (CBD) work?

Our bodies contain a specialized system called the endocannabinoid system responsible for physiological changes. The body produces endocannabinoids on its own. The endocannabinoid is neurotransmitters that bind to cannabinoid receptors.

There are two cannabinoid receptors; CB1 and CB2 receptors. The CB1 receptors are found throughout the body and particularly in the brain. They control your mood, emotion, movement, appetite, memory, and thinking.

The CB 2 receptors on the other hand are found in the immune system and influence inflammation and pain.

While THC binds strongly to CB1 receptors, CBD does not bind strongly to the receptors but instead stimulates the body to produce more endocannabinoids. CBD however can bind or activate other receptors such as serotonin receptor, vanilloid, and PPARs [peroxisome proliferator-activated receptors] receptors. CBD also acts as an antagonist to GPR55-orphan receptors.

CBD binds to the serotonin receptor which is implicated in anxiety, sleep, perception of pain, appetite, nausea, and vomiting.

CBD also binds to the vanilloid receptor which is known to mediate pain, inflammation, and body temperature.

CBD however acts as an antagonist to the GPR55 receptor that is usually expressed in various cancer types.

Cannabidiol also acts as an anti-inflammatory agent. It fights or eases inflammation.

Cannabidiol also possesses antioxidant properties that enable it to eliminate free radicals which are usually associated with degenerative disorders.

Anandamide (AEA) benefits

Anandamide(AEA) simulates the effects of Cannabis on our system, without its adverse effects. Anandamide helps us by stimulating our brain function in the following ways:

Anandamide (AEA)

① Enhancing brain capacity and memory

Enhancing your working memory capacity is a major Anandamide (AEA) benefits. It also helps you become more creative by processing information into new ideas. A study in mice has shown significant improvement in brain function. Thus if you want to improve your analytical skills, creative skills, or do well in your studies, Anandamide is the perfect solution.

② Acts as an appetite controller

If you want to follow a strict diet, appetite control is a must. One of the Anandamide benefits is it can help you control appetite and satiety cycles. You can easily control the pangs of hunger or cravings for junk with the help of Anandamide. This way, you can achieve your weight loss targets or targets of regaining shape. In the modern days staying healthy and fit largely depends on our food habits, and Anandamide supplements can help us. But the weight loss plans with Anandamide should be complemented with proper dietary plans. Severe undereating can lead to a sudden loss of body weight and, thus, metabolic problems. Also, in the case of lactating mothers, Anandamide consumption needs to be avoided.(5)(2015). Cannabidiol (CBD) and its analogs: a review of their effects on inflammation.

③ Neurogenesis

One way to increase your brain function capacity is to have new neurons or brain cells through Neurogenesis. This is true, especially you are nearing 40 or have gone beyond the age. Anandamide (AEA) helps in Neurogenesis.

Moreover, higher levels of Anandamide levels in the human body eradicate the risks of neurodegenerative diseases like Perkinson’sPerkinson’s disease, etc. At the old age, Anandamide helps in recovery from neurodegeneration related problems like memory loss, depression, fear, lack of control on the body, etc. Anandamide (AEA) helps older adults enjoy their retired life without worrying about their health issues.

Anandamide (AEA)

④ Controlling Sexual Desires

Anandamide (AEA) benefits control your sexual desire in two ways. In mild dosage, it enhances sexual desires. But with the heavy dose of Anandamide (AEA) reduces the sexual urge. Anandamide (AEA) improves your mood and relieves stress giving rise to the sexual urge. But a higher dose makes you sexually satisfied, and you find no need for sexual activity.

Anandamide (AEA)

⑤ Anti-Cancer properties

Anandamide (AEA) has ant carcinogenic properties through psychotropic effects. Anandamide (AEA) fights cancerous tissue growth. It is especially beneficial in breast cancer. Experiments are showing that it can be a good replacement for conventional drugs of cancer. Moreover, it is free of any side effects compared to the life-changing effects of conventional cancer drugs. Thus shortly, a large scale acceptance of Anandamide (AEA) might alleviate the pain that cancer patients go through during the treatment.

Antiemetic properties

Nausea and vomiting can also be controlled with Anandamide (AEA). It works with serotonin to control nausea. This makes Anandamide (AEA) an antiemetic solution during chemotherapy on cancer patients. This can be good for pregnant mothers also. But in the case of pregnant mothers, Anandamide (AEA) should be done only if recommended by her physician.

⑦ Pain Relief properties

By bonding with CB1, Anandamide (AEA) blocks the transmission of pain signals. This way, Anandamide (AEA) can be used for chronic pain relief in patients suffering from medical conditions like gout, arthritis, or sciatica. In older ages, pain is a constant companion. Anandamide (AEA) is a proven remedy for migraines and other severe headaches. Consumption of Anandamide (AEA) supplements in old age may help them win over pain and will also improve their quality of life.

Anandamide (AEA)

⑧ Mood Regulator

The endocannabinoid system controls our mood. Anandamide (AEA) controls our negative mind states like fear, anxiety, and increases happiness. This way, Anandamide (AEA) can function as a mood up-lifter, improve mental health, and improve your inner being. As Anandamide (AEA) supplements are non-addictive, it is highly recommended, especially for the working-age population, who need to continue working with high productivity in a very demanding and stressful environment.

Anandamide (AEA)

To fight off depression

Anandamide (AEA) can also fight off depression. A study on mice recently proved its antidepressant properties. Depression and related problems are taking a toll on our mental and physical health … even in our society. Addiction to nicotine, alcohol, drug abuse is often linked with depression. Even more severe conditions may lead people to take their lives. Depression can be a debilitating negative force that can even lead people to death. Anandamide (AEA) can be a great solution to this problem.

⑩ Fights off Inflammation and Edema

Anandamide (AEA) reduces cell swelling and edema. This way, it is also useful as an anti-inflammatory solution.

Other Benefits

Anandamide (AEA) can play a beneficial role in ovulation and implantation. Studies show that high Anandamide (AEA) levels ensure successful ovulation.

More than 60% of people will develop hypertension or chronic kidney diseases. Anandamide (AEA)can modulate kidney functions that cause the disease. Anandamide (AEA)has shown good results in solving problems caused by elevated blood pressure.

Anandamide (AEA) Natural Sources

i.Black Truffles (black fungi)

Black Truffles contains natural Anandamide.

ii.Tea and Herbs

Cannabis, cloves, cinnamon, black pepper, oregano, etc. improve Anandamide levels in our bodies. Tea is a very good source of Anandamide (AEA).

iii.Chocolate

Dark chocolate is one of the best sources of Anandamide. Cocoa powder is made up of oleolethanolamine and linoleoylethanolamine. The lower the breakdown of endocannabinoids and thus maintain the Anandamide levels in our body. Also, chocolate has theobromine, which helps Anandamide production.

iv.Essential Fatty Acids

Eggs, Chia seeds, flax seeds, sardines, hemp seeds are great sources of endocannabinoid enhancing fatty acids. In turn, this improves the level of Omega 3 and Omega 6 in our body improve endocannabinoid activity.

Anandamide (AEA) supplements and other ways to improve Anandamide levels

CBD (Cannabidiol)

One of the best ways to stimulate the endocannabinoid system is the consumption of CBD. CBD is the major source of medical marijuana. CBD inhibits FAAH and thus improves Anandamide levels in our body.

Exercise

Exercise brings in a feel-good factor in us. Exercise improves Anandamide levels in the body and thus increase your tendency to exercise harder. Experiments show that after exercise, they become calm and immune to pain. This is supposed because of CB1 and CB2’sCB2’s activation by Anandamide. It is seen 30 minutes of intense running or aerobics significantly increases the Anandamide levels in our bodies. It is also seen that migraines patients who take up aerobics tend to recover from the same. It is mainly because of the high levels of Anandamide produced in their body due to the heavy exercise.

Stress Reduction

People who can control stress have a higher level of Anandamide in them. Stress decreases CB1 receptors’ effect and thus reduces the levels of Anandamide and, in turn, show reduced cannabinoid function. Thus avoid stressful situations to improve overall wellbeing. One such solution is meditation.Mediation improves both Anandamide and dopamine levels in our body. Mediatbodiesleads to higher levels of oxytocin which further enhances Anandamide levels in our body. It’s like a good cycle of wellbeing. Anandamide helps you calm down and meditate; meditation further enhances your Anandamide levels and helps you get relief from stress.

Anandamide (AEA) Dosage

Like other endocannabinoids, the low external dosage of Anandamide is good for us. High doses are detrimental to our bodies. 1.0mg/kg. (per Kg of body weight) is an appropriatedosage of Anandamide (AEA). But if you are finding any problems, you must consult a physician immediately. In pregnant mothers and mothers who are breastfeeding they must consult their physicians before Anandamide (AEA) usage.

Anandamide (AEA) Side Effects

Anandamide has high tolerance and low side effects. You may experience some temporary difficulties like weight loss, dizziness, or vomiting. In certain cases, Anandamide (AEA) administration during breastfeeding (studied on adult mice) leads to weight gain, body fat accumulation, and even insulin resistance. This happens due to increased appetite leading to high food consumption.

Buying Anandamide (AEA) Supplements

We can easily understand to live a healthy life Anandamide (AEA) is essential. It helps in prevention and fighting off different ailments. To avoid Anandamide (AEA) deficiency, it is wise to consume supplements in the prescribed dosage. Generally, Anandamide (AEA) is available in oil (70% and 90%) and Powder forms (50%). China has become the major producer of Anandamide (AEA) supplements.

Cannabidiol (CBD)uses

The following are the cannabidiol uses;

● Treating seizure disorder (epilepsy)

Cannabidiol is used to treat seizures. CBD can impact the nerve cell’s sodium channels. An outstanding thing in epilepsy is the abnormal movement of sodium in and out of cells. This causes the brain to fire unusually leading to seizures. CBD has been found to reduce this unusual flow of sodium hence minimize seizures.

Some CBD products including Epidiolex have been approved for treating seizures caused by Lennox-Gastaut syndrome, Dravet syndrome, or tuber sclerosis complex. This prescription drug is also used along with other anti-seizure drugs to treat seizures in people suffering from Sturge-Weber syndrome, febrile infection-related epilepsy syndrome, and certain genetic disorders causing epileptic encephalopathy.

In a 2016 study involving 214 people suffering from epilepsy, CBD was administered at 2 to 5 mg daily for 12 weeks in addition to the existing epilepsy medication. It was found that the participants had fewer seizures experienced per month.

● May be used to treating cancer

Cannabidiol oil may be used to reduce the symptoms associated with cancer and side effects of cancer treatment such as pain, nausea, and vomiting.

In a study of 16 cancer patients undergoing chemotherapy, CBD used along with THC was found to reduce the chemotherapy-related side effects such as nausea and vomiting.

Another study demonstrated that CBD effectively inhibited the proliferation of breast cancer in mice.

● Exhibits neuroprotective properties

CBD’s ability to influence the endocannabinoid system and other brain signaling systems makes it beneficial to people with neurological disorders. CBD oil can also reduce the inflammation that is associated with neurodegenerative disorders.

Most studies have focused on CBD’s use in treating neurological disorders such as epilepsy and multiple sclerosis. Research suggests its potential use in treating other disorders such as Alzheimer’s disease and Parkinson’s disease.

In a long-term study of mice predisposed to Alzheimer’s disease, CBD was found to prevent cognitive decline.

● Treating type 1 diabetes

Type 1 diabetes is a form of diabetes that occurs when the immune system attacks cells in the pancreas, this results in inflammation.

CBD has been found to poses anti-inflammatory properties, it may therefore ease inflammation or even delay the occurrence of type 1 diabetes.

In a study of rats with diabetes, CBD was found to protect neurons by preventing cognitive decline and reducing nerve inflammation.

Cannabidiol (CBD)benefits

Cannabidiol has a wide range of therapeutical benefits.
Below are some of the cannabidiol benefits;

● May reduce anxiety and depression

Cannabidiol (CBD) can help reduce anxiety as well as reduce some anxiety-related behaviors associated with conditions such as general anxiety disorder, panic disorder, social anxiety disorder, and post-traumatic stress disorder (PTSD).

In a study of mice, cannabidiol was found to exhibit both anti-anxiety and antidepressant effects.

● Can relieve pain

CBD provides a more natural pain relief than conventional drugs.

Our bodies contain a specialized endocannabinoid system responsible for regulating sleep, pain, inflammation, and immune system response. The body thus produces endocannabinoids, the neurotransmitters that bind to cannabinoid receptors in your nervous system.

CBD has been shown to impact the endocannabinoid system thus reducing pain and inflammation.

In combination with THC, CBD oil can be used to treat pain related to various conditions such as multiple sclerosis, arthritis, sciatic nerve pain, and spinal cord injuries.

In a study of people suffering from rheumatoid arthritis, CBD used together with THC was found to significantly relieve pain during movement and at rest as well as improved sleep quality in the patients.

● May reduce acne

Acne is a skin condition that affects many people. It may be due to genetics, inflammation, and overproduction of sebum (an oily substance made by the sebaceous glands in the skin).

Research shows that CBD can help reduce acne by acting as an anti-inflammatory agent as well as reducing sebum production.

For example, a human study found that CBD oil was able to prevent the overproduction of sebum by the sebaceous glands thus an effective treatment of acne.

● May help quit smoking and drug withdrawal

CBD in form of an inhaler may help smokers to use fewer cigarettes as well as reduce their addiction to nicotine. This plays role in helping one to quit smoking.

In a 2018 study CBD was noted to help lower the desire for tobacco after withdrawal. It was found to help  one to be relaxed.

Cannabidiol (CBD) may offer other benefits including;

  • May help people with insomnia get quality and uninterrupted sleep
  • Can relieve you from headaches or migraine,
  • Can also help reduce nausea,
  • Can help relieve allergies or even asthma
  • May be used in the treatment of lung conditions.

Cannabidiol (CBD)dosage

Cannabidiol oil dosage depends on the form of administration, the intended purpose, age, and other underlying conditions. If you intend to use cannabidiol oil you should consult your doctor on how to take CBD oil before acquiring it for professional advice on proper use and dosage. How to take CBD oil will depend on the form of administration including;

  • tablet and capsules are taken orally or sublingually
  • Cbd oil is taken orally
  • Cbd oil for application on the skin
  • Nasal sprays for inhaling

Since cannabidiol is relatively new there is no standard dosage for the various uses. However, the FDA has approved the use of Epidiolex, which is one of the cannabis-derived products. It is approved for the treatment of severe epilepsy caused by Dravet syndrome or Lennox-Gastaut syndrome.

The recommended dosage for Epidiolex is as follows:

  • The starting dosage is 2.5 mg/Kg of body weight taken twice daily, making a total dosage of 5 mg/kg each day.
  • After 1 week, the dose may be increased to 5 mg/kg twice daily, which is a total of 10 mg/kg per day.

While many CBD oil benefits are stipulated one may also experience some cannabidiol side effects including nausea, fatigue, diarrhea, loss of appetite, and irritability.

Cannabidiol (CBD)for sale (Buy Cannabidiol (CBD)in bulk)

Cannabidiol oil for sale is readily available online. However, when you consider cannabidiol buy it from a trusted source approved for sale of cannabidiol oil to get the best CBD oil.

You can check for customer reviews on most websites to find out the trusted CBD products supplier offering the best CBD oil.

Always buy cannabidiol (CBD) in bulk to enjoy discounted prices.

Follow the instructions on how to take CBD oil carefully to avoid experiencing the possible CBD oil adverse effects.

Where to buy Anandamide (AEA) powder in bulk

Cofttek   product

Established in 2008, Cofttek is a high-tech Dietary Supplement company from Luohe City, Henan Province, China.

Package: 25kg/ drum

Hope this helps!! What are you waiting for then?  Get Anandamide home and make life easier!

Article by:Dr. Zeng

Article by:

Dr. Zeng

Co-founder, the company’s core administration leadership; PhD received from Fudan University in organic chemistry. More than nine years of experience in organic chemistry and drug design synthesis; nearly 10 research papers published in authoritative journals, with more than five Chinese patents.

References

(1).Mallet PE, Beninger RJ (1996). “The endogenous cannabinoid receptor agonist anandamide impairs memory in rats”. Behavioural Pharmacology. 7 (3): 276–284

(2).Mechoulam R, Fride E (1995). “The unpaved road to the endogenous brain cannabinoid ligands, the anandamides”. In Pertwee RG (ed.). Cannabinoid receptors. Boston: Academic Press. pp. 233–

(3).Rapino, C.; Battista, N.; Bari, M.; Maccarrone, M. (2014). “Endocannabinoids as biomarkers of human reproduction”. Human Reproduction Update. 20 (4): 501–516.

(4).(2015). Cannabidiol (CBD) and its analogs: a review of their effects on inflammation. Bioorganic & Medicinal Chemistry, 23(7), 1377-1385.

(5).Corroon, J., & Phillips, J. A. (2018). A Cross-Sectional Study of Cannabidiol Users. Cannabis and cannabinoid research, 3(1), 152–161.

(6).National Center for Biotechnology Information (2020). PubChem Compound Summary for CID 644019, Cannabidiol. Retrieved October 27, 2020, from .

(7).R de Mello Schier, A., P de Oliveira Ribeiro, N., S Coutinho, D., Machado, S., Arias-Carrión, O., A Crippa, J., … & C Silva, A. (2014). Antidepressant-like and anxiolytic-like effects of cannabidiol: a chemical compound of Cannabis sativa. CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders), 13(6), 953-960.

(8).Blessing, E. M., Steenkamp, M. M., Manzanares, J., & Marmar, C. R. (2015). Cannabidiol as a Potential Treatment for Anxiety Disorders. Neurotherapeutics: the journal of the American Society for Experimental NeuroTherapeutics12(4), 825–836.

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