What is Anandamide (AEA)

Anandamide (AEA), also known as the bliss molecule, or N-arachidonoylethanolamine (AEA), is a fatty acid neurotransmitter. The name Anadamida (AEA) is derived from the Sanskrit of Joy “Ananda.” Raphael Mechoulam coined the term. How, along with his two assistants, W. A. Devane and Lumír Hanuš, first discovered “Anandamide” in 1992. Anandamide (AEA) is a great fix for a lot of our physical and mental problems. 

 

How Anandamide (AEA) Works

Anandamide(AEA) is derived from the non-oxidative metabolism of eicosatetraenoic acid. Anandamide (AEA) is a lipid mediator and functions as an endogenous ligand of CB1 receptors and modulates its reward circuitry. It is an important neurotransmitter in the endocannabinoid system, named after Cannabis. It helps regulate the flow of neurochemical systems to keep your body and mind functioning smoothly. It is found that the Anandamide structure is similar to tetrahydrocannabinol (THC), the main psychotic component of Cannabis. Thus Anandamide changes mood simulates what popularly is known as Cannabis high.

It is naturally produced in our body as per the brain’s instruction by a condensation reaction in neurons. The condensation reaction controlled by calcium ion and cyclic monophosphate adenosine takes place between arachidonic acid and ethanolamine. 

Anandamide increases happiness by interacting with cannabinoid receptors in the nervous and peripheral nervous system, CB1 and CB2. CB1 receptors target Motor activity (movement) and coordination, Thinking, Appetite, Short terms memory, Pain perception, and Immunity. At the same time, CB2 receptors target major organs like the Liver, Gut, kidney, Pancreas, Adipose tissues, Skeletal muscle, Bone, Eye, Tumours, Reproductive system, Immune system, Respiratory tract, skin, Central Nervous system, and Cardiovascular system.

In our body, N-arachidonoylethanolamine breaks down into fatty acid amide hydrolase (FAAH) enzyme and produces arachidonic acid and ethanolamine. If FAAH’sFAAH’s action can be slowed down, we can reap Anandamide’sAnandamide’s benefits for a longer period.

Anandamide (AEA)

Anandamide (AEA) benefits

Anandamide(AEA) simulates the effects of Cannabis on our system, without its adverse effects. Anandamide helps us by stimulating our brain function in the following ways:

  1. Enhancing brain capacity and memory

Enhancing your working memory capacity is a major Anandamide (AEA) benefits. It also helps you become more creative by processing information into new ideas. A study in mice has shown significant improvement in brain function. Thus if you want to improve your analytical skills, creative skills, or do well in your studies, Anandamide is the perfect solution.

  1. Acts as an appetite controller

If you want to follow a strict diet, appetite control is a must. One of the Anandamide benefits is it can help you control appetite and satiety cycles. You can easily control the pangs of hunger or cravings for junk with the help of Anandamide. This way, you can achieve your weight loss targets or targets of regaining shape. In the modern days staying healthy and fit largely depends on our food habits, and Anandamide supplements can help us. But the weight loss plans with Anandamide should be complemented with proper dietary plans. Severe undereating can lead to a sudden loss of body weight and, thus, metabolic problems. Also, in the case of lactating mothers, Anandamide consumption needs to be avoided.

  1. Neurogenesis

One way to increase your brain function capacity is to have new neurons or brain cells through Neurogenesis. This is true, especially you are nearing 40 or have gone beyond the age. Anandamide (AEA) helps in Neurogenesis.

Moreover, higher levels of Anandamide levels in the human body eradicate the risks of neurodegenerative diseases like Perkinson’sPerkinson’s disease, etc. At the old age, Anandamide helps in recovery from neurodegeneration related problems like memory loss, depression, fear, lack of control on the body, etc. Anandamide (AEA) helps older adults enjoy their retired life without worrying about their health issues.

  1. Controlling Sexual Desires

Anandamide (AEA) benefits control your sexual desire in two ways. In mild dosage, it enhances sexual desires. But with the heavy dose of Anandamide (AEA) reduces the sexual urge. Anandamide (AEA) improves your mood and relieves stress giving rise to the sexual urge. But a higher dose makes you sexually satisfied, and you find no need for sexual activity.

  1. Anti-Cancer properties

Anandamide (AEA) has ant carcinogenic properties through psychotropic effects. Anandamide (AEA) fights cancerous tissue growth. It is especially beneficial in breast cancer. Experiments are showing that it can be a good replacement for conventional drugs of cancer. Moreover, it is free of any side effects compared to the life-changing effects of conventional cancer drugs. Thus shortly, a large scale acceptance of Anandamide (AEA) might alleviate the pain that cancer patients go through during the treatment. 

  1. Antiemetic properties

Nausea and vomiting can also be controlled with Anandamide (AEA). It works with serotonin to control nausea. This makes Anandamide (AEA) an antiemetic solution during chemotherapy on cancer patients. This can be good for pregnant mothers also. But in the case of pregnant mothers, Anandamide (AEA) should be done only if recommended by her physician.

  1. Pain Relief properties

By bonding with CB1, Anandamide (AEA) blocks the transmission of pain signals. This way, Anandamide (AEA) can be used for chronic pain relief in patients suffering from medical conditions like gout, arthritis, or sciatica. In older ages, pain is a constant companion. Anandamide (AEA) is a proven remedy for migraines and other severe headaches. Consumption of Anandamide (AEA) supplements in old age may help them win over pain and will also improve their quality of life.

  1. Mood Regulator

The endocannabinoid system controls our mood. Anandamide (AEA) controls our negative mind states like fear, anxiety, and increases happiness. This way, Anandamide (AEA) can function as a mood up-lifter, improve mental health, and improve your inner being. As Anandamide (AEA) supplements are non-addictive, it is highly recommended, especially for the working-age population, who need to continue working with high productivity in a very demanding and stressful environment.

  1. To fight off depression

Anandamide (AEA) can also fight off depression. A study on mice recently proved its antidepressant properties. Depression and related problems are taking a toll on our mental and physical health … even in our society. Addiction to nicotine, alcohol, drug abuse is often linked with depression. Even more severe conditions may lead people to take their lives. Depression can be a debilitating negative force that can even lead people to death. Anandamide (AEA) can be a great solution to this problem.

  1. Fights off Inflammation and Edema

Anandamide (AEA) reduces cell swelling and edema. This way, it is also useful as an anti-inflammatory solution.

  1. Improves Fertility

Anandamide (AEA) can play a beneficial role in ovulation and implantation. Studies show that high Anandamide (AEA) levels ensure successful ovulation.

  1. Solves Hyper-Tension and Kidney dysfunction

More than 60% of people will develop hypertension or chronic kidney diseases. Anandamide (AEA)can modulate kidney functions that cause the disease. Anandamide (AEA)has shown good results in solving problems caused by elevated blood pressure. 

 

Anandamide (AEA) Natural Sources

  • Essential Fatty Acids

Eggs, Chia seeds, flax seeds, sardines, hemp seeds are great sources of endocannabinoid enhancing fatty acids. In turn, this improves the level of Omega 3 and Omega 6 in our body improve endocannabinoid activity.

  • Tea and Herbs

Cannabis, cloves, cinnamon, black pepper, oregano, etc. improve Anandamide levels in our bodies. Tea is a very good source of Anandamide (AEA).

  • Chocolate

Dark chocolate is one of the best sources of Anandamide. Cocoa powder is made up of oleolethanolamine and linoleoylethanolamine. The lower the breakdown of endocannabinoids and thus maintain the Anandamide levels in our body. Also, chocolate has theobromine, which helps Anandamide production.

  • Black Truffles (black fungi)

Black Truffles contains natural Anandamide.

 

Anandamide (AEA) supplements and other ways to improve Anandamide levels

  • CBD (Cannabidiol)

One of the best ways to stimulate the endocannabinoid system is the consumption of CBD. CBD is the major source of medical marijuana. CBD inhibits FAAH and thus improves Anandamide levels in our body. 

  • Exercise

Exercise brings in a feel-good factor in us. Exercise improves Anandamide levels in the body and thus increase your tendency to exercise harder. Experiments show that after exercise, they become calm and immune to pain. This is supposed because of CB1 and CB2’sCB2’s activation by Anandamide. It is seen 30 minutes of intense running or aerobics significantly increases the Anandamide levels in our bodies. It is also seen that migraines patients who take up aerobics tend to recover from the same. It is mainly because of the high levels of Anandamide produced in their body due to the heavy exercise.

  • Stress Reduction

People who can control stress have a higher level of Anandamide in them. Stress decreases CB1 receptors’ effect and thus reduces the levels of Anandamide and, in turn, show reduced cannabinoid function. Thus avoid stressful situations to improve overall wellbeing. One such solution is meditation.

Mediation improves both Anandamide and dopamine levels in our body. Mediatbodiesleads to higher levels of oxytocin which further enhances Anandamide levels in our body. It’s like a good cycle of wellbeing. Anandamide helps you calm down and meditate; meditation further enhances your Anandamide levels and helps you get relief from stress.

Anandamide (AEA)

 

Anandamide (AEA) Dosage

Like other endocannabinoids, the low external dosage of Anandamide is good for us. High doses are detrimental to our bodies. 1.0mg/kg. (per Kg of body weight) is an appropriate dosage of Anandamide (AEA). But if you are finding any problems, you must consult a physician immediately. In pregnant mothers and mothers who are breastfeeding they must consult their physicians before Anandamide (AEA) usage. 

 

Anandamide (AEA) Side Effects

Anandamide has high tolerance and low side effects. You may experience some temporary difficulties like weight loss, dizziness, or vomiting. In certain cases, Anandamide (AEA) administration during breastfeeding (studied on adult mice) leads to weight gain, body fat accumulation, and even insulin resistance. This happens due to increased appetite leading to high food consumption.

 

Buying  Anandamide (AEA) Supplements

We can easily understand to live a healthy life Anandamide (AEA) is essential. It helps in prevention and fighting off different ailments. To avoid Anandamide (AEA) deficiency, it is wise to consume supplements in the prescribed dosage. Generally, Anandamide (AEA) is available in oil (70% and 90%) and Powder forms (50%). China has become the major producer of Anandamide (AEA) supplements.

 

What is Cannabidiol (CBD)?

Cannabidiol (CBD) is the second most abundant active compounds known as cannabinoids found in the cannabis sativa (marijuana or hemp). Tetrahydrocannabinol (THC) is the most prevalent and also the most psychoactive cannabinoid found in the cannabis plant. THC is associated with getting a “high” sensation.

However, CBD is not psychoactive and is derived from the hemp plant which contains low amounts of THC. This property has made CBD gain popularity in the health and wellness sector.

Cannabidiol (CBD) oil on the other hand is derived from the cannabis plant by adding the extracted CBD to carrier oil such as hemp seed oil or coconut oil.

 

How does Cannabidiol (CBD) work?

Our bodies contain a specialized system called the endocannabinoid system responsible for physiological changes. The body produces endocannabinoids on its own. The endocannabinoid is neurotransmitters that bind to cannabinoid receptors.

There are two cannabinoid receptors; CB1 and CB2 receptors. The CB1 receptors are found throughout the body and particularly in the brain. They control your mood, emotion, movement, appetite, memory, and thinking.

The CB 2 receptors on the other hand are found in the immune system and influence inflammation and pain.

While THC binds strongly to CB1 receptors, CBD does not bind strongly to the receptors but instead stimulates the body to produce more endocannabinoids. CBD however can bind or activate other receptors such as serotonin receptor, vanilloid, and PPARs [peroxisome proliferator-activated receptors] receptors. CBD also acts as an antagonist to GPR55-orphan receptors.

CBD binds to the serotonin receptor which is implicated in anxiety, sleep, perception of pain, appetite, nausea, and vomiting.

CBD also binds to the vanilloid receptor which is known to mediate pain, inflammation, and body temperature.

CBD however acts as an antagonist to the GPR55 receptor that is usually expressed in various cancer types.

Cannabidiol also acts as an anti-inflammatory agent. It fights or eases inflammation.

Cannabidiol also possesses antioxidant properties that enable it to eliminate free radicals which are usually associated with degenerative disorders.

 

Cannabidiol (CBD) uses

The following are the cannabidiol uses;

 

Treating seizure disorder (epilepsy)

Cannabidiol is used to treat seizures. CBD can impact the nerve cell’s sodium channels. An outstanding thing in epilepsy is the abnormal movement of sodium in and out of cells. This causes the brain to fire unusually leading to seizures. CBD has been found to reduce this unusual flow of sodium hence minimize seizures.

Some CBD products including Epidiolex have been approved for treating seizures caused by Lennox-Gastaut syndrome, Dravet syndrome, or tuber sclerosis complex. This prescription drug is also used along with other anti-seizure drugs to treat seizures in people suffering from Sturge-Weber syndrome, febrile infection-related epilepsy syndrome, and certain genetic disorders causing epileptic encephalopathy.

In a 2016 study involving 214 people suffering from epilepsy, CBD was administered at 2 to 5 mg daily for 12 weeks in addition to the existing epilepsy medication. It was found that the participants had fewer seizures experienced per month.

 

May be used to treating cancer

Cannabidiol oil may be used to reduce the symptoms associated with cancer and side effects of cancer treatment such as pain, nausea, and vomiting.

In a study of 16 cancer patients undergoing chemotherapy, CBD used along with THC was found to reduce the chemotherapy-related side effects such as nausea and vomiting.

Another study demonstrated that CBD effectively inhibited the proliferation of breast cancer in mice.

 

Exhibits neuroprotective properties

CBD’s ability to influence the endocannabinoid system and other brain signaling systems makes it beneficial to people with neurological disorders. CBD oil can also reduce the inflammation that is associated with neurodegenerative disorders.

Most studies have focused on CBD’s use in treating neurological disorders such as epilepsy and multiple sclerosis. Research suggests its potential use in treating other disorders such as Alzheimer’s disease and Parkinson’s disease.

In a long-term study of mice predisposed to Alzheimer’s disease, CBD was found to prevent cognitive decline.

 

Treating type 1 diabetes

Type 1 diabetes is a form of diabetes that occurs when the immune system attacks cells in the pancreas, this results in inflammation.

CBD has been found to poses anti-inflammatory properties, it may therefore ease inflammation or even delay the occurrence of type 1 diabetes.

In a study of rats with diabetes, CBD was found to protect neurons by preventing cognitive decline and reducing nerve inflammation.

 

Cannabidiol (CBD) benefits

Cannabidiol has a wide range of therapeutical benefits.

Below are some of the cannabidiol benefits;

 

May reduce anxiety and depression

Cannabidiol (CBD) can help reduce anxiety as well as reduce some anxiety-related behaviors associated with conditions such as general anxiety disorder, panic disorder, social anxiety disorder, and post-traumatic stress disorder (PTSD).

In a study of mice, cannabidiol was found to exhibit both anti-anxiety and antidepressant effects.

 

Can relieve pain

CBD provides a more natural pain relief than conventional drugs.

Our bodies contain a specialized endocannabinoid system responsible for regulating sleep, pain, inflammation, and immune system response. The body thus produces endocannabinoids, the neurotransmitters that bind to cannabinoid receptors in your nervous system.

CBD has been shown to impact the endocannabinoid system thus reducing pain and inflammation.

In combination with THC, CBD oil can be used to treat pain related to various conditions such as multiple sclerosis, arthritis, sciatic nerve pain, and spinal cord injuries.

In a study of people suffering from rheumatoid arthritis, CBD used together with THC was found to significantly relieve pain during movement and at rest as well as improved sleep quality in the patients.

 

May reduce acne

Acne is a skin condition that affects many people. It may be due to genetics, inflammation, and overproduction of sebum (an oily substance made by the sebaceous glands in the skin).

Research shows that CBD can help reduce acne by acting as an anti-inflammatory agent as well as reducing sebum production.

For example, a human study found that CBD oil was able to prevent the overproduction of sebum by the sebaceous glands thus an effective treatment of acne.

 

May help quit smoking and drug withdrawal

CBD in form of an inhaler may help smokers to use fewer cigarettes as well as reduce their addiction to nicotine. This plays role in helping one to quit smoking.

In a 2018 study CBD was noted to help lower the desire for tobacco after withdrawal. It was found to help  one to be relaxed.

Cannabidiol (CBD) may offer other benefits including;

  • May help people with insomnia get quality and uninterrupted sleep
  • Can relieve you from headaches or migraine,
  • Can also help reduce nausea,
  • Can help relieve allergies or even asthma
  • May be used in the treatment of lung conditions.

 

Cannabidiol (CBD) dosage 

Cannabidiol oil dosage depends on the form of administration, the intended purpose, age, and other underlying conditions. If you intend to use cannabidiol oil you should consult your doctor on how to take CBD oil before acquiring it for professional advice on proper use and dosage. How to take CBD oil will depend on the form of administration including;

  • tablet and capsules are taken orally or sublingually
  • Cbd oil is taken orally
  • Cbd oil for application on the skin
  • Nasal sprays for inhaling

Since cannabidiol is relatively new there is no standard dosage for the various uses. However, the FDA has approved the use of Epidiolex, which is one of the cannabis-derived products. It is approved for the treatment of severe epilepsy caused by Dravet syndrome or Lennox-Gastaut syndrome.

The recommended dosage for Epidiolex is as follows:

  • The starting dosage is 2.5 mg/Kg of body weight taken twice daily, making a total dosage of 5 mg/kg each day.
  • After 1 week, the dose may be increased to 5 mg/kg twice daily, which is a total of 10 mg/kg per day.

While many CBD oil benefits are stipulated one may also experience some cannabidiol side effects including nausea, fatigue, diarrhea, loss of appetite, and irritability.

 

Cannabidiol (CBD) for sale (Buy Cannabidiol (CBD) in bulk)

Cannabidiol oil for sale is readily available online. However, when you consider cannabidiol buy it from a trusted source approved for sale of cannabidiol oil to get the best CBD oil.

You can check for customer reviews on most websites to find out the trusted CBD products supplier offering the best CBD oil.

Always buy cannabidiol (CBD) in bulk to enjoy discounted prices.

Follow the instructions on how to take CBD oil carefully to avoid experiencing the possible CBD oil adverse effects.

 

 

Where to buy Anandamide (AEA) powder in bulk

Cofttek   product

Established in 2008, Cofttek is a high-tech Dietary Supplement company from Luohe City, Henan Province, China.

  • Package: 25kg/ drum

Hope this helps!! What are you waiting for then?  Get Anandamide home and make life easier!

 

References
  1. Mallet PE, Beninger RJ (1996). “The endogenous cannabinoid receptor agonist anandamide impairs memory in rats”. Behavioural Pharmacology. 7 (3): 276–284
  2. Mechoulam R, Fride E (1995). “The unpaved road to the endogenous brain cannabinoid ligands, the anandamides”. In Pertwee RG (ed.). Cannabinoid receptors. Boston: Academic Press. pp. 233–
  3. Rapino, C.; Battista, N.; Bari, M.; Maccarrone, M. (2014). “Endocannabinoids as biomarkers of human reproduction”. Human Reproduction Update. 20 (4): 501–516.
  4. (2015). Cannabidiol (CBD) and its analogs: a review of their effects on inflammation. Bioorganic & Medicinal Chemistry, 23(7), 1377-1385. DOI:10.1016/j.bmc.2015.01.059.
  5. Corroon, J., & Phillips, J. A. (2018). A Cross-Sectional Study of Cannabidiol Users. Cannabis and cannabinoid research, 3(1), 152–161. https://doi.org/10.1089/can.2018.0006.
  6. National Center for Biotechnology Information (2020). PubChem Compound Summary for CID 644019, Cannabidiol. Retrieved October 27, 2020, from https://pubchem.ncbi.nlm.nih.gov/compound/Cannabidiol.
  7. R de Mello Schier, A., P de Oliveira Ribeiro, N., S Coutinho, D., Machado, S., Arias-Carrión, O., A Crippa, J., … & C Silva, A. (2014). Antidepressant-like and anxiolytic-like effects of cannabidiol: a chemical compound of Cannabis sativa. CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders), 13(6), 953-960.
  8. Blessing, E. M., Steenkamp, M. M., Manzanares, J., & Marmar, C. R. (2015). Cannabidiol as a Potential Treatment for Anxiety Disorders. Neurotherapeutics: the journal of the American Society for Experimental NeuroTherapeutics12(4), 825–836. https://doi.org/10.1007/s13311-015-0387-1
  9. ANANDAMIDE (AEA) (94421-68-8)

 

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